Infectious Diseases

LALISTAT: TREATING MYCOBACTERIAL DISEASES

Sep 16, 2017

| Reference: 

B75235

  • Novel approach for treating tuberculosis (TB) by the Lipase inhibitor Lalistat
  • Lalistat specifically abrogates the intracellular growth of mycobacterium tuberculosis
  • The use of Lalistat in combination with known antimycobacterial might offer an urgently needed opportunity to improve and shorten TB therapy
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SMALL MOLECULE HDAC6 INHIBITORS

Sep 16, 2017

| Reference: 

B73271

  • ‍HDAC6 is a promising target for the treatment of chronic immune and inflammatory disorders such as rheumatoid arthritis (RA)
  • Marbostat are new small molecule inhibitors of HDAC6 with superior characteristics: in comparison to the established HDAC6 inhibitor Tubastatin A, the new inhibitors are more potent and specific, and most importantly they highly and selectively inhibit the enzyme activity of HDAC6 without destroying the protein.
  • Provision of a viable alternative to first line NSAIDs (non-steroidal anti-inflammatory drugs) in the treatment of RA
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METHOD FOR IDENTIFICATION OF TARGET ANTIGENS OF T-CELLS

Sep 16, 2017

| Reference: 

B70007

  • ‍Identify peptide antigens of any CD8 restricted TCR (CD4 ongoing)
  • Affinity independent and extremely sensitive method
  • Focused on autoimmune diseases and psoriasis but also applicable to tumor immunology
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