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Result 1 - 10 of 93 Technology Offers
A new possibility to cure multiple sclerosisImmunology & Inflammation DiseasesScientists of the Klinikum rechts der Isar in Munich have found a novel antigen (Inward rectifier potassium channel, KIR4.1) which reacts to serum antibodies of a subgroup of Multiple sclerosis (MS) patients or having a predisposition to develop MS. In the multi step validation step they have shown that KIR4.1 is a target of the autoimmune response in MS and may play an important role in the pathogenesis of disease. Novel BMP2 antagonist inhibitors for bone graft substitutionBiologicalsBiochemical Engineering Medical Technology
Recombinant bone morphogenetic protein 2 (BMP-2) is a known bone graft substitute used in the treatment of bone fractures and bone defects and is currently available on the market. BMP-2 must be applied in high concentrations to induce bone formation in clinical settings. Its limited therapeutic efficacy may be due to the presence of BMP antagonists that neutralize exogenous BMP-2. Inventors at the University of Würzburg (Germany) have identied a novel inactive BMP-2 mutein, named L51P, which acts as an inhibitor of BMP antagonists noggin, chordin and gremlin. In vitro and in vivo validation studies with a combination of BMP-2 and L51P led to a signi cant increase in BMP activity. New explosivesChemistryTwo new high performing secondary explosives, namely ABTOX and TKX50 have been synthesized in excellent yields even in larger quantities. They were completely characterized with respect to their chemical and energetic properties. Both show great performance while being less sensitive than commonly used explosives such as hexogen and octogen. Montageplus+ - Sensor system to support installation planningMechanical engineeringWireless sensor system for the assembly process creation Metall-Matrix-Composite materials with graduated volume salary of non-metallic componentsMechanical engineering Use of the internal oxidation for specific material influencing in the production of Metall-Matrix-Composite materials Anode material for high temperature fuel cellsElectrical engineering & electronicsMechanical engineering Use of the internal oxidation for the specific material influencing in the production of functional composite materials Porous zirconium oxide ceramicsMechanical engineering Use of the internal oxidation for specific material influecing in the production of highly porous and temperature-stable ceramics New non-viral transfection agents better than PEIDrug Delivery
The invention describes new PDMAEMA-based vehicles for the highly efficient transport of polynucleotides into cells and also into their nucleus. The new polyelectrolyte particles offer a series of advantages compared to known synthetic non-viral vectors, including the current gold standard poly(ethylene Novel peptide inhibitors for the treatment of malignant melanomaOncologyMalignant melanoma is characterized by aggressive local growth and early formation of metastasis. The Melanoma Inhibitory Activity (MIA) protein is known to promote invasion of melanoma cells into healthy tissue and triggers formation of metastases. After determining the functional state of MIA, the inventors of the University of Regensburg (Germany) have identi ed several peptides which inhibit MIA protein functional activity and strongly reduce the formation of metastases in vivo. These inhibitors may offer a novel treatment strategy in preventing or reducing of formation of metastases in malignant melanoma. Gastro Tube for Self ApplicationMedical technology & devicesA bioresorbable stomach tube saves the patient the uncomfortable taking of the jet fluid. The acceptance of colonoscopy can be encreased enormeously. |
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