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  • Physical Sciences
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Microarray to determine responsiveness of tumors to antiangiogenic treatment

Ref-Nr: B62721

Category
Pharmaceutics & medicine
University
Friedrich-Alexander-Universität Erlangen-Nürnberg
Stage of development
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Keywords
Tumor therapy
colorectal cancer
angiogenesis
antiangiogenic therapy, Bevacizumab
hGBP-1
Contact
Bayerische Patentallianz GmbH
T: +49 89 5480177-0
F: +49 89 5480177-99
kontakt@baypat.de

Contact person
Peer Biskup

Microarray to determine responsiveness of tumors to antiangiogenic treatment
Figure 1: GBP-1 is associated with a prolonged cancer-related 5-year survival in CRC (Naschberger et al, Int J Cancer 2008) Cancer-related 5-year survival of patients with GBP-1-positive and -nega-tive colonic carcinoma. The cancer-related survival is depicted by a Kaplan-Meier-Curve and 95% confidence intervals.

Colorectal cancer (CRC) is the third most frequently occurring cancer in both sexes. It ranks second in developed countries. Tumor growth beyond the critical two to three millimeter diameter and metastasis require angiogenesis. Therefore, in later tumor stages, antiangiogenic treatment offers a strategy that has been shown in clinic to improve outcomes in patients with advanced or metastatic colorectal cancer (mCRC). Today, several antiangiogenic drugs for tumor therapeutic application have been approved, e.g. Bevacizumab (Avastin®), Cetuximab (Erbitux®) or Panitumumab (Vectibix®). Nevertheless, 20% of the patients do not respond and are resistant to antiangiogenic therapy.
This invention provides a method which allows to further improve the efficacy of antiangiogenic therapy in colorectal cancer (CRC). This is achieved by detection and exclusion of patients, which are in a therapy resistant tumor stage.

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Semiconducting Nano-Wires of Tin Phosphide Iodide (SnIP)

Ref-Nr: B75074

Category
Electrical engineering & electronics
University
Technische Universität München
Stage of development
Prototype
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Keywords
Semiconductor
Double Helix
Photovoltaics
LED
Sensors
Contact
Bayerische Patentallianz GmbH
T: +49 89 5480177-0
F: +49 89 5480177-99
kontakt@baypat.de

Contact person
Peer Biskup

Semiconducting Nano-Wires of Tin Phosphide Iodide (SnIP)
SnIP is the first inorganic substance with a double helix structure

The first inorganic compound with a double helix structure is a semiconductor with interesting mechanical properties.

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Fast Optimization of Network Load

Ref-Nr: B75231

Category
Energy & environment
University
Technische Universität München
Stage of development
Prototype
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Keywords
power grids
approximation theory
power distribution planning
probabilistic logic
Contact
Bayerische Patentallianz GmbH
T: +49 89 5480177-0
F: +49 89 5480177-99
kontakt@baypat.de

Contact person
Peer Biskup

Fast Optimization of Network Load
CRA (Common Rank Approximation) is characterized by high calculation efficiency  and  high precision

Method for fast optimization of network load.

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Compressed Air Storage for Industrial Applications

Ref-Nr: B76054

Category
Energy & environment
University
Technische Universität München
Stage of development
Producibility
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Keywords
Compressed Air
energy storage
industry
Contact
Bayerische Patentallianz GmbH
T: +49 89 5480177-0
F: +49 89 5480177-99
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Contact person
Peer Biskup

Compressed Air Storage for Industrial Applications
© Bildergala - Fotolia

Increase the flexibility of your compressed air system. The presented invention allows to shift the compressor load and to secure your compressed air supply.

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Efficiency increase for ORC power plants

Ref-Nr: B76094

Category
Energy & environment
University
Technische Universität München
Stage of development
Producibility
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Keywords
ORC
condenser
cooling
compact
cost-efficient
Contact
Bayerische Patentallianz GmbH
T: +49 89 5480177-0
F: +49 89 5480177-99
kontakt@baypat.de

Contact person
Peer Biskup

 Efficiency increase for ORC power plants
Picture: Air condenser for OR (© Chair for Energy Systems, Wieland, 2016)

The investment for the condenser in ORC power plant is high. In order to reduce costs or to increase the overall efficiency an efficient condensation concept is desired or necessary. The invention can be realized with any commercial heat exchanger and is based on an optimized integration of the condenser.

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Determining the presence of an analyte by means of small magnetic particles

Ref-Nr:

Category
Measurement technology & microsystems
University
Hochschule für angewandte Wissenschaften Würzburg-Schweinfurt
Stage of development
Producibility
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Keywords
bioanalysis
diagnostics
process control
point-of-care diagnostics
magnetic particles
Contact
Bayerische Patentallianz GmbH
T: +49 89 5480177-0
F: +49 89 5480177-99
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Contact person
Peer Biskup

The in the invention described technology allows the parallel detection of several analytes in a liquid test sample with the help of functionalized magnetic particles. In comparison to conventional optical read-out technologies this technology offers a high robustness, low material costs and the possibility of in-vivo measurements while obtaining an equivalent sensitivity.

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Method and Device for Two-Dimensional Separation of Ionic Species

Ref-Nr: B74051

Category
Chemistry & biotechnology
University
Universität Regensburg
Stage of development
Prototype
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Keywords
Ion chromatography
Capillary electrophoresis
Two-dimensional separation
Contact
Bayerische Patentallianz GmbH
T: +49 89 5480177-0
F: +49 89 5480177-99
kontakt@baypat.de

Contact person
Peer Biskup

Method and Device for Two-Dimensional Separation of Ionic Species

The technology relates to a method which realizes a two-dimensional separation of ionic species on the basis of the online coupling of ion chromatography and capillary electrophoresis. Through the orthogonality of the single methods the peak capacity can be increased significantly. The separation of ionic species is improved in a cost-effective way, e.g. for complex mixtures of nucleotides or cyclic nucleotides.

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Safety binding system for ski touring and telemarking

Ref-Nr: B73247

Category
Food & health
Transportation & mobility
University
Technische Universität München
Stage of development
Prototype
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Keywords
Safety binding system
ski touring
telemarking
knee injury
Contact
Bayerische Patentallianz GmbH
T: +49 89 5480177-0
F: +49 89 5480177-99
kontakt@baypat.de

Contact person
Peer Biskup

Safety binding system for ski touring and telemarking
© Jag_cz

The invention proposes a solution for a novel ski binding system, which sets for ski touring as well as telemarking new benchmarks in terms of comfort and safety. Thereby it fulfills the requirements of two different forms of skiing in an entirely original form and opens up completely novel applications. Due to its modular design new ways of marketing the system can be introduced while an efficient production can be realized.

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Waste safeguard for forming processes using „vibrations”

Ref-Nr: B70209

Category
Mechanical engineering
University
Hochschule für angewandte Wissenschaften Kempten
Stage of development
Prototype
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Keywords
forming processes
slug pulling
machine tools
forming tools
waste safeguard
Contact
Bayerische Patentallianz GmbH
T: +49 89 5480177-0
F: +49 89 5480177-99
kontakt@baypat.de

Contact person
Peer Biskup

Waste safeguard for forming processes using „vibrations”
© Nataliya Hora

The invention describes a waste safeguard for forming processes, which is using locally applied vibrations to avoid a slug pulling. Implementing this technology increases the operating speed and improves the quality of the machined part. The technology is flexible in use and can be integrated in different forming processes and tools.

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3D-Printing using focused ultrasound beams

Ref-Nr: B75001

Category
Medical Technology
University
Technische Universität München
Stage of development
Producibility
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Keywords
3D-Printing
polymer
generative manufacturing
Contact
Bayerische Patentallianz GmbH
T: +49 89 5480177-0
F: +49 89 5480177-99
kontakt@baypat.de

Contact person
Peer Biskup

3D-Printing using focused ultrasound beams
© TUM

The invention belongs to the field of generative/additive manufacturing (better known as „3D printing”). Additive manufacturing describes usually building up a structure layer by layer from a granulate or liquid using physical/chemical processes as melting or curing of a material.

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