Diagnostics/Biomarker

Method for assessing the efficacy of immunmodulatory drugs

Apr 1, 2019

| Reference: 

B74042

• Biomarker using CD147/MCT1 destabilization as mechanism

• For the use of IMiDs (Immunomodulatory drugs)

• To treat hematologic malignancies like multiple myeloma (MM)

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PROGNOSTIC AND PREDICTIVE BIOMARKER FOR MELANOMA

Mar 29, 2019

| Reference: 

B78091

• Prognostic test for patients with malignant melanoma
• Estimates patient life expectancy
• Biomarker for predicts melanoma therapy response

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A CALCIUM-SENSOR FOR NMR/MRI BASED DIAGNOSTIC IMAGING USING HYPERPOLARIZED XENON

Nov 7, 2018

| Reference: 

B75123

  • in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
  • in particular for diagnosing and/or monitoring treatment of diseases
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PH-BIOSENSORS BASED ON HYPERPOLARIZED ZYMONIC ACID FOR NONINVASIVE IMAGING AND SPECTROSCOPY

Oct 30, 2018

| Reference: 

B73167

  • Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
  • Potential for diagnosis and therapy of diseases characterized by aberrant acid-base balances
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URINARY MARKER FOR BLADDER CANCER DETECTION

Nov 13, 2017

| Reference: 

B71211

  • The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
  • LASP-1 overcomes the limitation of currently used cystoscopy and urine cytology for diagnosis of UCB
  • LASP-1 is detected in voided urine sediment of bladder cancer patients and is combinable with a second marker to further raise specificity/sensitivity
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A NEW TARGET IN CANCER THERAPY

Sep 16, 2017

| Reference: 

B74064

  • Cancer cells use an extracellular citrate supply as an important energy source and substrate for the synthesis of critical cellular building blocks (e.g. fatty acids). 
  • A highly specialized plasma membrane protein (pmCiC, plasma membrane citrate carrier) was found to be responsible for citrate uptake in cancer cells
  • pmCiC is a novel and specific marker and therapeutic target for cancer cells
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