Diagnostics/Biomarker

A CALCIUM-SENSOR FOR NMR/MRI BASED DIAGNOSTIC IMAGING USING HYPERPOLARIZED XENON

Nov 7, 2018

| Reference: 

B75123

  • in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
  • in particular for diagnosing and/or monitoring treatment of diseases
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PH-BIOSENSORS BASED ON HYPERPOLARIZED ZYMONIC ACID FOR NONINVASIVE IMAGING AND SPECTROSCOPY

Oct 30, 2018

| Reference: 

B73167

  • Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
  • Potential for diagnosis and therapy of diseases characterized by aberrant acid-base balances
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ANTIGENIC PEPTIDES FOR THE DIAGNOSIS, THERAPY-MONITORING AND TREATMENT OF PSORIASIS

May 4, 2018

| Reference: 

B75034

  • ‍Diagnosis of psoriasis (monitoring disease acitivity / efficacy of treatment / defining disease risk)
  • Treatment of psoriasis (Using altered peptide ligands / using toxin-coupled toxins / blocking HLA-C/T-cell-interactions)
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SPECIFIC IMAGING AGENTS FOR PRIMARY ALDOSTERONISM DIAGNOSTICS

Mar 23, 2018

| Reference: 

B76123

  • non-invasive differentiation between bilateral hyperplasia and unilateral adenoma by PET-imaging
  • radiolabeled aldosterone synthase (CYP11B2) inhibitors with high selectively, easy synthesis and high chemical and metabolic stability
  • alternative for the so far performed invasive diagnostic adrenal vein sampling in combination with cross-sectional imaging
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URINARY MARKER FOR BLADDER CANCER DETECTION

Nov 13, 2017

| Reference: 

B71211

  • The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
  • LASP-1 overcomes the limitation of currently used cystoscopy and urine cytology for diagnosis of UCB
  • LASP-1 is detected in voided urine sediment of bladder cancer patients and is combinable with a second marker to further raise specificity/sensitivity
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A NEW TARGET IN CANCER THERAPY

Sep 16, 2017

| Reference: 

B74064

  • Cancer cells use an extracellular citrate supply as an important energy source and substrate for the synthesis of critical cellular building blocks (e.g. fatty acids). 
  • A highly specialized plasma membrane protein (pmCiC, plasma membrane citrate carrier) was found to be responsible for citrate uptake in cancer cells
  • pmCiC is a novel and specific marker and therapeutic target for cancer cells
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