Infectious Diseases

IMMUNOTHERAPY FOR CHRONIC LIVER DISEASES

Sep 3, 2018

| Reference: 

B72272

  • Novel vaccination strategy against chronic liver diseases through stimulation of IMATEs with TLR9-L
  • IMATEs are an anatomic compartment within the liver tissue consisting of myeloid cells
  • iMATEs overcome regulatory cues that limit immune response during chronic liver infections
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CHEMICAL DISRUPTION OF CLPX INHIBITS MULTIRESISTANT S. AUREUS

May 4, 2018

| Reference: 

B76071

  • In vitro & in vivo proof of concept
  • Novel compounds for the inhibiton of bacterial virulence
  • Available as mono therapy or as combination therapy with antibiotics
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SMALL MOLECULE HDAC6 INHIBITORS

Sep 16, 2017

| Reference: 

B73271

  • ‍HDAC6 is a promising target for the treatment of chronic immune and inflammatory disorders such as rheumatoid arthritis (RA)
  • Marbostat are new small molecule inhibitors of HDAC6 with superior characteristics: in comparison to the established HDAC6 inhibitor Tubastatin A, the new inhibitors are more potent and specific, and most importantly they highly and selectively inhibit the enzyme activity of HDAC6 without destroying the protein.
  • Provision of a viable alternative to first line NSAIDs (non-steroidal anti-inflammatory drugs) in the treatment of RA
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METHOD FOR IDENTIFICATION OF TARGET ANTIGENS OF T-CELLS

Sep 16, 2017

| Reference: 

B70007

  • Identify peptide (CD4 ongoing)
  • Affinity independent and extremely sensitive method
  • Focused on autoimmune diseases and psoriasis but also applicable to tumor immunology
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