OrbitaTreat - an innovative implantation system
OrbitaTreat - an innovative implantation system
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OrbitaTreat - an innovative implantation system
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The use of DAT for immunotherapies
The use of DAT for immunotherapies
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Anti-SEMA7A for the treatment of post-ischemic tissue damage
Anti-SEMA7A for the treatment of post-ischemic tissue damage
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Cyclopeptides for treating amyloid diseases and their comorbidities
Cyclopeptides for treating amyloid diseases and their comorbidities
- Strong binding to Aβ42 (AD), IAPP (T2D) and αSyn (PD)
- Act at nanomolar to low micromolar concentrations and cheap to synthesize
- Highly soluble, non-amyloidogenic, and non-toxic
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Antidromic strategies to target RASopathies
Antidromic strategies to target RASopathies
- RAS detected at low levels on cell surface independent of the HLA complex
- Targeting of extracellularly expressed RAS on cancer cells via bispecific T cell engager
- Relevant for novel immunotherapies for RAS-driven malignancies
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Hydrogel prevents post-infarct cardiac arrhythmia
Hydrogel prevents post-infarct cardiac arrhythmia
- Injectable hydrogel integrates and matures stem cell-derived cardiomyocytes safely
- Reduces risk of post-infarct arrhythmias
- Validated in in vivo studies
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Functionalized docetaxel probes for mitotic spindles
Functionalized docetaxel probes for mitotic spindles
- Enables dense and homogeneous labeling of spindle microtubules for all mitotic phases
- Compatible with advanced imaging methods
- Survives chemical fixation
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Multifunctional Anti-Amyloid Peptides
Multifunctional Anti-Amyloid Peptides
- MCIPs as candidates for treatment of PD, AD and T2D
- Proteolytic stability in human plasma and effective crossing of human blood brain barrier
- Promising in vivo data ongoing
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Proton Beam Range Verification Using Ionoacoustics
Proton Beam Range Verification Using Ionoacoustics
- Submillimeter range verification of proton beam Bragg peak
- Excellent signal-to-noise ratio of ionoacoustic information
- Technology validated in water and abdominal phantoms
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Practical and safe fluorination of white phosphorus (P4)
Practical and safe fluorination of white phosphorus (P4)
- One-pot reactions with simple and commercially available reagents
- Safe fluorination, no hazardous educts, intermediates or waste
- Sustainable closed-loop or (electro-)catalytic reactions routes possible
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Isothiocyanates as anti-thrombotics and thrombolytics
Isothiocyanates as anti-thrombotics and thrombolytics
- The isothiocyanates AITC, BITC and PEITC prevent platelet activation and reverse aggregation.
- The ITCs have potential as therapeutic and preventive drugs for thromboembolic conditions.
- ITCs are small molecules and can be produced cost-effectively and are highly stable.
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TMEM16A inhibitors as a Polycystic kidney disease (PKD) treatment option
TMEM16A inhibitors as a Polycystic kidney disease (PKD) treatment option
- TMEM16A inhibitors include approved and well-tolerated drugs such as niclosamide and benzbromarone
- Significant suppression of renal cysts
- Combinable with other strategies
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Sustainable phosphorus functionalization with disulfides
Sustainable phosphorus functionalization with disulfides
- One-pot reactions with simple, cheap reagents to obtain valuable monophosphorus compounds
- Sustainable closed-loop or (electro-)catalytic reactions routes possible
- High process safety: no hazardous educts, intermediates or by-products
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New linker for Protein A boosts binding capacity
New linker for Protein A boosts binding capacity
- Rigid inter-domain linker enhances the accessibility of individual Protein A binding sites
- Simple way to boost binding capacity of Protein A resins 1.5 to 2-fold
- Potential to reduce costs and increase productivity in downstream platform processes
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Apnea Treat - a minimally invasive implant for Sleep apnea therapy
Apnea Treat - a minimally invasive implant for Sleep apnea therapy
- Treating sleep apnea without the need for patient compliance
- Minimal tissue damage, no discomfort to be expected
- Low manufacturing costs for the implant system
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Carbon nanofiber electrodes for use in lateral flow assays
Carbon nanofiber electrodes for use in lateral flow assays
- Easy on-site analsysis for consumers at home maintained
- Higher sensitivity and more quantitative measurement
- Microfluidic systems planned
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Cytosolic RNA depletion by polymeric nanoparticles
Cytosolic RNA depletion by polymeric nanoparticles
- Mucin nanoparticles cross-linked with anti-miRNA oligonucleotides
- Treating systemic diseases associated with increased cellular RNA levels
- Depletion of miRNA-21 reduced tumor growth in vivo by 50%
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A Biomarker for Post-COVID Syndrome
A Biomarker for Post-COVID Syndrome
- Simplified diagnosis of Post-Covid
- Identification of PCS-specific SARS-CoV-2 S-protein epitopes
- Demonstrated feasibility of high-throughput screening
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Novel clinical biomarker for hepatic steatosis
Novel clinical biomarker for hepatic steatosis
- Applicable for detecting or grading hepatic steatosis
- Fast, simple and inexpensive
- Minimal non-invasive
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BICEP: A Bio- Inspired Compliant Elbow Prosthesis
BICEP: A Bio- Inspired Compliant Elbow Prosthesis
- Compact and bio-inspired joint design with soft properties
- Compliant behavior in both the sagittal and transversal planes
- Safe absorption of unintentional impacts
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Puncturing system for a safer tracheostomy
Puncturing system for a safer tracheostomy
- Enables the physician to reliably identify the correct site and trajectory of the puncturing instrument
- Especially suited for patients with a challenging anatomy (e.g obese tissue, goiter, short neck)
- PDT significantly decreases costs, time and manpower requirements
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Grainstorm revolutionizes the ethanolic fermentation of starchy raw materials in the production of distilled spirits and simplifies starch-based fermentation
Grainstorm revolutionizes the ethanolic fermentation of starchy raw materials in the production of distilled spirits and simplifies starch-based fermentation
- Mashing takes place at low temperatures with a dispersing device (up to 32°C)
- No need for cooling the mash, fermentation at mashing temperature
- Complete conversion of starch, very high yields
- Greatly simplified process execution, significant savings in equipment and mashing time
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Peptide agent against multi- resistant bacteria
Peptide agent against multi- resistant bacteria
- antibacterial agent for multi drug resistant Gram-negative infections
- fast action (hours), also bactericidal against non-replicating bacteria
- especially for patients with autoantibodies against endogenous BPI
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LINAC Cavities Made by Additive Manufacturing
LINAC Cavities Made by Additive Manufacturing
- Relevant reduction of manufacturing costs
- Freedom in cavitiy design due to additive manufacturing
- Optimized cavity geometries reduce LINAC operating costs while increasing operating time and lifetime
- Innovation can be used in particle accelerators for e.g. radiation therapy, cargo scanning or food
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New catalysts for the production of superior PHB
New catalysts for the production of superior PHB
- Biocompatible and biodegradable plastic with superior material properties compared to bacterial PHB
- Cost-effective production via ring opening polymerization of ß‐butyrolactone
- Thermomechanical properties similar to petrochemical PP, material suitable for melt processing
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Novel coating of catheter-based cardiac devices
Novel coating of catheter-based cardiac devices
- Scar tissue as a central problem after stent implantation
- Local coating of cardiac devices inhibits re-narrowing of vessel
- Dual anti-proliferative and anti-migratory effect on cells
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The T-Cell-Therapy Success Code: Signatures of recent T-cell activation allow isolation of highly functional tumor-specific T cell receptors
The T-Cell-Therapy Success Code: Signatures of recent T-cell activation allow isolation of highly functional tumor-specific T cell receptors
- Cost-effective isolation of highly functional tumor-specific TCRs
- Method using predictive markers to identify TCRs of high functional quality
- Isolation of TCRs from easily accessible peripheral blood
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PosH-Tag: Cost effective and highly speci- fic biomolecule separation with bare silica surfaces and immobilization using bare ma- gnetic iron-oxide nanoparticles
PosH-Tag: Cost effective and highly speci- fic biomolecule separation with bare silica surfaces and immobilization using bare ma- gnetic iron-oxide nanoparticles
- Platform for protein purification and immobilization
- Efficient and cost effective separation of target molecules
- Without NTA modification and the use of imidazole
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New cell therapy cures metastatic cancer in mouse
New cell therapy cures metastatic cancer in mouse
- New RESURRECT NK and T cell therapy cures metastatic cancer in mouse
- RESURRECT T and NK cells overcome immunosuppression in tumors and metastases
- RESURRECT cells are effective in tumors resistant to standard immunotherapies
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Novel approach for disruption of pubic symphysis
Novel approach for disruption of pubic symphysis
- Trauma accidents often result in life threatening pelvic injuries
- 2 component cable-clamp implant for disrupted pubic symphysis
- Fewer complications compared to conventional approach
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Implant and implant applicator for endoscopic and customizable anastomosis
Implant and implant applicator for endoscopic and customizable anastomosis
- System for endoluminal anastomosis
- Adjustable to the lumen size of the patient’s intestine
- Force application mechanism at flexible endoscope tip for arbitrary shapes
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Nanoparticles for the targeted treatment of neovascular ocular diseases
Nanoparticles for the targeted treatment of neovascular ocular diseases
- systemic therapy instead of intravitreal antibody injections
- a single systemic injection cured retinopathy of prematurity in mouse model
- causal treatment of all neovascular ocular diseases
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Lab on a Chip for rapid testing applications
Lab on a Chip for rapid testing applications
- Rapid detection of bio-chemical substances in fluids
- Easy and fast – requires only small amount of testfluid
- No sample preparation needed
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Natural Antioxidants for food or cosmetic oils and fats
Natural Antioxidants for food or cosmetic oils and fats
- Highly effective, edible natural antioxidants for oils and fats
- Antioxidant and antibacterial effects for long shelf life
- For edible oils and fats, cosmetics and other oil-based products
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Sustainable one-pot preparation of versatile organo-phosphorus compounds
Sustainable one-pot preparation of versatile organo-phosphorus compounds
- Simple one-pot reaction using mild, non-corrosive conditions
- Reaction yields e.g. stannyl phosphines for direct reaction with electrophiles
- No separation/purification steps necessary
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TMEM16A inhibitors as a treatment option for cystic fibrosis
TMEM16A inhibitors as a treatment option for cystic fibrosis
- TMEM16A inhibitors represent a causal treatment for cystic fibrosis
- They reduce both excessive mucus formation and airway contraction
- Repurposing possible: TMEM16A inhibitors include FDA-approved and well-tolerated drugs
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Virus-mimetic nanoparticles for diabetic nephropathy
Virus-mimetic nanoparticles for diabetic nephropathy
- Specific drug delivery via nanoparticles
- Virus like targeting in a two-stage process
- Dose reduction compared to free drug
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Innovative solid-liquid reactor for high-speed mass transfer & catalysis without clogging
Innovative solid-liquid reactor for high-speed mass transfer & catalysis without clogging
- Fully scalable rotating reactor for quick mass transfer reactions
- Broad variety of chemical- and pharmaceutical applications such as extraction & biocatalysis
- Especially effective for the use of small or deformable particles as solid reactant (no clogging)
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Reducing waste and time – Novel approach allows for rapid isotope production for medical diagnostics
Reducing waste and time – Novel approach allows for rapid isotope production for medical diagnostics
- ⁹⁹ᵐTc as one of the most important medical radioisotopes
- Novel dry-chemical separation of molybdenum and uranium
- More environmentally friendly production with less toxic waste
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Innovative braiding technique and bifurcation stents with a seamless transition area
Innovative braiding technique and bifurcation stents with a seamless transition area
- Optimized braiding technique for bifurcation stents
- Seamless transition area with a homogenous density for maximum stability and flexibility at bifurcation sites
- Secondary branches can be produced simultaneously
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Tau aggregation inhibiting peptides as a basis for future therapies for tauopathies
Tau aggregation inhibiting peptides as a basis for future therapies for tauopathies
- Tau aggregation inhibiting peptides
- Strongly bind to tau monomers, -oligomers and -fibrils
- Suitable for future tauopathy therapies
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Point-of-care blood test for early sepsis diagnosis
Point-of-care blood test for early sepsis diagnosis
- Diagnostic test for suspected sepsis (bacterial, viral incl. SARS-CoV, fungal)
- Easy and broadly applicable test, small blood sample volumes needed
- Allows much earlier diagnosis (~36h) than currently possible
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Natural Antioxidants for food or cosmetic oils and fats
Natural Antioxidants for food or cosmetic oils and fats
- Natural, highly effective and non-toxic active ingredients
- Active ingredients commercially available at very low cost
- Stronger stabilization than petrochemical benchmark antioxidants
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Protein Purification/Immobilization through negPeps
Protein Purification/Immobilization through negPeps
- NegPeps (magnetic particle binding peptides) are novel peptides with the potential to replace the common affinity tags based protein purification/immobilization
- NegPeps bind to magnetic nanoparticles in a reversible and controlled manner
- No specific surface functionalization necessary
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Rotating reactor for heterogeneous transfer of substances
Rotating reactor for heterogeneous transfer of substances
- Reactor for mass transfer reactions
- Biotech, food and beverage processing
- For small or deformable particles
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NF-κB-activated dendritic cells
NF-κB-activated dendritic cells
- that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
- DCs activation is mediated by via mRNA transfection
- Activated DCs lead to strong expansion of memory T cells and are much more stable than other DC vaccination products
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Flexible and breathable nonwovens with superior electrical conductivity
Flexible and breathable nonwovens with superior electrical conductivity
- Bendable and breathable material with metal-like electrical conductivity
- Low silver content required, simple wet-laid process
- For e.g. lightweight electrodes and electric shielding
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Innovative ceramic fiber composite materials with high thermal and corrosion stabilities
Innovative ceramic fiber composite materials with high thermal and corrosion stabilities
- Superior ceramic fiber prepregs for high-temperature stable materials
- Prepregs storable without climate control, reversible drying process
- Little to no volume shrinkage during sintering
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