As human hair wigs look just like natural hair, is it prone to similar issues as natural hair, and wigs harboring lice is one of them.
Appropriate Standard Thirty seven carries a free-sprung stability with fake richard mille out regulator, including Patek Philippe’s Gyromax, and the rate is adjusted by simply Four weight screws (within platinum) on the harmony edge.
BayPAT | Virus-mimetic nanoparticles for diabetic nephropathy Zum Seiteninhalt springen
Back to overview

09.10.2020

Virus-mimetic nanoparticles for diabetic nephropathy

Life Sciences, Arzneistoffgabe

  • Specific drug delivery via nanoparticles
  • Virus like targeting in a two-stage process
  • Dose reduction compared to free drug

Ihr Kontakt

Dr. Sami Caner

E-Mail:
scaner@baypat.de
Telefon:
+49 (0) 89 5480177 – 30
Referenznummer:
B79122

Herausforderung

Poor target cell specificity is currently a major shortcoming of nanoparticles used for biomedical applications. It causes significant material loss to off-target sites and poor availability at the intended delivery site. To overcome this limitation, designed nano-particles that identify cells in a virus-like manner could provide a solution to this problem.

Innovation

The invention described here involves virus-mimetic nanoparticles that are able to transport drugs into the mesangium of the kidney. The nanoparticles use a novel sequential recognition process that is used in a similar way by viruses to recognize their target cells. In contrast to other nanomaterials, the virus-mimetic particles are able to effectively accumulate in the cells of the mesangium. By encapsulating drug candidates such as pirfenidone or cinaciguat, a rational treatment of diabetic nephropathy can be promised for the first time, which occurs in 40% of the more than 400 million people with diabetes worldwide and for whom there is currently no treatment option other than dialysis and organ transplantation.

Kommerzielle Möglichkeiten

Drug Delivery for Diabetic Nephropathy

Entwicklungsstatus

Proof of Concept with mesangial cells

References

  • 1

    Fleischmann, D., Maslanka Figueroa, S., Beck, S., Abstiens, K., Witzgall, R., Schweda, F., … Goepferich, A. M. (2020). Adenovirus Mimetic Nanoparticles: Sequential Ligand-Receptor Interplay as a Universal Tool for Enhanced In Vitro/In Vivo Cell Identification. ACS Applied Materials & Interfaces.

  • 2

    Maslanka Figueroa, S., Fleischmann, D., Beck, S., Tauber, P., Witzgall, R., Schweda, F., & Goepferich, A. (2020). Nanoparticles Mimicking Viral Cell Recognition Strategies Are Superior Transporters into Mesangial Cells. Advanced Science,

  • 3

    Maslanka Figueroa, S., Veser, A., Abstiens, K., Fleischmann, D., Beck, S., & Goepferich, A. (2019). Influenza A virus mimetic nanoparticles trigger selective cell uptake. Proceedings of the National Academy of Sciences

Haben wir Ihr Interesse geweckt?

Finden Sie den richtigen Ansprechpartner für spezielle Themen auf unserer Team-Seite oder benutzen Sie für Ihre Anfrage einfach das Kontakt-Formular.