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  • Antidromic strategies to target RASopathies

    B82137

    Antidromic strategies to target RASopathies

    • RAS detected at low levels on cell surface independent of the HLA complex
    • Targeting of extracellularly expressed RAS on cancer cells via bispecific T cell engager
    • Relevant for novel immunotherapies for RAS-driven malignancies
  • Additives for Adhesives in Wood Construction Products

    B84040

    Additives for Adhesives in Wood Construction Products

    • Better penetration of the adhesive into the wood structure
    • Smooth and wide distribution of forces, which avoids delamination
    • Adaptable formulation for the different wood species
  • Hydrogel prevents post-infarct cardiac arrhythmia

    B85042

    Hydrogel prevents post-infarct cardiac arrhythmia

    • Injectable hydrogel integrates and matures stem cell-derived cardiomyocytes safely
    • Reduces risk of post-infarct arrhythmias
    • Validated in in vivo studies
  • Multifunctional Anti-Amyloid Peptides

    B84076

    Multifunctional Anti-Amyloid Peptides

    • MCIPs as candidates for treatment of PD, AD and T2D
    • Proteolytic stability in human plasma and effective crossing of human blood brain barrier
    • Promising in vivo data ongoing
  • Proton Beam Range Verification Using Ionoacoustics

    Y21012

    Proton Beam Range Verification Using Ionoacoustics

    • Submillimeter range verification of proton beam Bragg peak
    • Excellent signal-to-noise ratio of ionoacoustic information
    • Technology validated in water and abdominal phantoms
  • High-Efficiency Converter for Variable Speed Drives

    B85022

    High-Efficiency Converter for Variable Speed Drives

    • Increased conversion results in lower energy costs and increases net electricity
    • Reduced power losses in the form of dissipated heat increase the lifetime of components
    • Cheaper components can be used or the converter can be designed to be more compact
  • Microbial production of atactic PHB

    B84065

    Microbial production of atactic PHB

    • Sustainable and microbial fermentative production of atactic PHB, which can be applied to any industrial microorganism
    • Compared to natural microbial PHB, atactic microbial PHB is less crystalline and brittle
    • Various carbon sources can be used such as carbohydrates, hydrogen, CO2, and methane
  • Practical and safe fluorination of white phosphorus (P4)

    B82082

    Practical and safe fluorination of white phosphorus (P4)

    • One-pot reactions with simple and commercially available reagents
    • Safe fluorination, no hazardous educts, intermediates or waste
    • Sustainable closed-loop or (electro-)catalytic reactions routes possible
  • Isothiocyanates as anti-thrombotics and thrombolytics

    B84012

    Isothiocyanates as anti-thrombotics and thrombolytics

    • The isothiocyanates AITC, BITC and PEITC prevent platelet activation and reverse aggregation.
    • The ITCs have potential as therapeutic and preventive drugs for thromboembolic conditions.
    • ITCs are small molecules and can be produced cost-effectively and are highly stable.
  • Fire-resistant wood by impregnation with cement

    B80005

    Fire-resistant wood by impregnation with cement

    • Use of impregnatable wood types such as beech or pine sapwood
    • Dispersion of ultra fine cement particles and protective agents in glycol
    • Dispersion impregnation by standard vacuum process – subsequent water storage enables hydration inside the wood structure
  • Sustainable phosphorus functionalization with disulfides

    B82082

    Sustainable phosphorus functionalization with disulfides

    • One-pot reactions with simple, cheap reagents to obtain valuable monophosphorus compounds
    • Sustainable closed-loop or (electro-)catalytic reactions routes possible
    • High process safety: no hazardous educts, intermediates or by-products
  • New linker for Protein A boosts binding capacity

    B84062

    New linker for Protein A boosts binding capacity

    • Rigid inter-domain linker enhances the accessibility of individual Protein A binding sites
    • Simple way to boost binding capacity of Protein A resins 1.5 to 2-fold
    • Potential to reduce costs and increase productivity in downstream platform processes
  • Device for fast parallelized additive manufacturing

    B80011

    Device for fast parallelized additive manufacturing

    • Challenging geometries such as overhang structures can be printed without support structures
    • Ideal method to functionalize objects (e.g. thermal and electrical conductivity, addition of sensors & actuators)
    • Multimaterial objects printable (e.g. surface coatings etc.)
  • Vibration-Resistant Microphone Based on ALTP

    B83091

    Vibration-Resistant Microphone Based on ALTP

    • Effective separation of sound and vibrations
    • No bulky shielding in windy conditions
    • No eigenfrequent resonances of the membrane of a classical microphone
  • Parabolic and wave-shaped cogwheels

    B83202

    Parabolic and wave-shaped cogwheels

    • Improved load capacity allowes higher rotation speeds
    • Homogeneus power distribution
    • Less noise and reduced wear offer comfort and longer lifespan
  • Cytosolic RNA depletion by polymeric nanoparticles

    B83117

    Cytosolic RNA depletion by polymeric nanoparticles

    • Mucin nanoparticles cross-linked with anti-miRNA oligonucleotides
    • Treating systemic diseases associated with increased cellular RNA levels
    • Depletion of miRNA-21 reduced tumor growth in vivo by 50%
  • A Biomarker for Post-COVID Syndrome

    B83046

    A Biomarker for Post-COVID Syndrome

    • Simplified diagnosis of Post-Covid
    • Identification of PCS-specific SARS-CoV-2 S-protein epitopes
    • Demonstrated feasibility of high-throughput screening
  • BICEP: A Bio- Inspired Compliant Elbow Prosthesis

    B82103

    BICEP: A Bio- Inspired Compliant Elbow Prosthesis

    • Compact and bio-inspired joint design with soft properties
    • Compliant behavior in both the sagittal and transversal planes
    • Safe absorption of unintentional impacts
  • Puncturing system for a safer tracheostomy

    B81019

    Puncturing system for a safer tracheostomy

    • Enables the physician to reliably identify the correct site and trajectory of the puncturing instrument
    • Especially suited for patients with a challenging anatomy (e.g obese tissue, goiter, short neck)
    • PDT significantly decreases costs, time and manpower requirements
  • Grainstorm revolutionizes the ethanolic fermentation of starchy raw materials in the production of distilled spirits and simplifies starch-based fermentation

    B81132

    Grainstorm revolutionizes the ethanolic fermentation of starchy raw materials in the production of distilled spirits and simplifies starch-based fermentation

    • Mashing takes place at low temperatures with a dispersing device (up to 32°C)
    • No need for cooling the mash, fermentation at mashing temperature
    • Complete conversion of starch, very high yields
    • Greatly simplified process execution, significant savings in equipment and mashing time
  • Boosting sensitivity and speed for quantum sensing

    B83077

    Boosting sensitivity and speed for quantum sensing

    • sensitivity increase of 300-500% compared to existing methods
    • lower-power pulse laser, allowing more efficient energy utilization
    • minimal disruption to often heat sensitive biological or chemical samples
    • 10 times faster readout speed
  • Peptide agent against multi- resistant bacteria

    B81112

    Peptide agent against multi- resistant bacteria

    • antibacterial agent for multi drug resistant Gram-negative infections
    • fast action (hours), also bactericidal against non-replicating bacteria
    • especially for patients with autoantibodies against endogenous BPI
  • Vibration Decoupling for Dilution Refrigerators

    B83028

    Vibration Decoupling for Dilution Refrigerators

    • Possible upgrade for commercial cryostats with minimal impact on sample volume size
    • In dry cryostats, almost no vibrations are transferred to the sample even when the pulse-tube cooler is on
    • Multi-stage thermal insulation and mechanical damping ensure minimal interference from external support
  • Sensor-Independent Autonomous Mobility

    B81122

    Sensor-Independent Autonomous Mobility

    • Less need for retraining with new data as sensors evolve and are replaced
    • Simpler and faster implementation of new sensor models at reduced development costs
    • Factoring in field of view, mounting angle, resolution, and sensor nonlinearity
    • Successfully tested with both camera and LiDAR images
  • Shear cutting: inline measurement of wear and cut quality

    B82142

    Shear cutting: inline measurement of wear and cut quality

    • Can be used independently of material and tool type
    • Instantaneous monitoring of process and cut surface characteristics
    • Maintains optimal tool performance
    • Easy retrofitting
  • LINAC Cavities Made by Additive Manufacturing

    Y20000

    LINAC Cavities Made by Additive Manufacturing

    • Relevant reduction of manufacturing costs
    • Freedom in cavitiy design due to additive manufacturing
    • Optimized cavity geometries reduce LINAC operating costs while increasing operating time and lifetime
    • Innovation can be used in particle accelerators for e.g. radiation therapy, cargo scanning or food
  • Primary sensor for magnetostrictive force measurement

    B79005

    Primary sensor for magnetostrictive force measurement

    • Ideal for "lost sensor" concepts, e.g. for precise bearing adjustment
    • Can potentially deliver data while machines or vehicles are running
    • Extending operating life of bearings, minimizing machine down time and service cost
    • Huge commercial impact, highest customer satisfaction
  • Wavefront sensor for advanced surface metrology

    B81164

    Wavefront sensor for advanced surface metrology

    • Improvement over Shack-Hartmann surface sensing: Absence of microlens array increases resolution
    • Advantageous compared to tactile measurement systems: Contact-free, fast, cost-efficient
    • Construction from readily available components
    • Large slope acceptance angle
  • New catalysts for the production of superior PHB

    B82063

    New catalysts for the production of superior PHB

    • Biocompatible and biodegradable plastic with superior material properties compared to bacterial PHB
    • Cost-effective production via ring opening polymerization of ß‐butyrolactone
    • Thermomechanical properties similar to petrochemical PP, material suitable for melt processing
  • Contactless measure and visualize planar vibrations

    B81003

    Contactless measure and visualize planar vibrations

    • Multi-material suitable: even for sandwich- and composite, capable for natural materials, plastic and all kinds of metals.
    • Performs complex analyses and inspection tasks or non-destructive in-line quality testing.
    • Standard microphones with simple callibration process - intuitive handling.
    • The variable evaluation enables easy-to-understand graphical illustrations.
  • Moisture sensor for structures and building materials

    B81163

    Moisture sensor for structures and building materials

    • Compensates for material shrinkage
    • For measurements in wood, wood-based materials, concrete, anhydride, plastics and many more.
    • Short-term measurement or permanent monitoring
  • Novel coating of catheter-based cardiac devices

    B79124

    Novel coating of catheter-based cardiac devices

    • Scar tissue as a central problem after stent implantation
    • Local coating of cardiac devices inhibits re-narrowing of vessel
    • Dual anti-proliferative and anti-migratory effect on cells
  • New cell therapy cures metastatic cancer in mouse

    B81137

    New cell therapy cures metastatic cancer in mouse

    • New RESURRECT NK and T cell therapy cures metastatic cancer in mouse
    • RESURRECT T and NK cells overcome immunosuppression in tumors and metastases
    • RESURRECT cells are effective in tumors resistant to standard immunotherapies
  • Novel approach for disruption of pubic symphysis

    B80189

    Novel approach for disruption of pubic symphysis

    • Trauma accidents often result in life threatening pelvic injuries
    • 2 component cable-clamp implant for disrupted pubic symphysis
    • Fewer complications compared to conventional approach
  • Backflushable gradient bed filter for particle separation

    B80032

    Backflushable gradient bed filter for particle separation

    • Increased filtrate yield and separation efficiency
    • Enormous cost reduction through low running costs, an optimized backflushing process and the use of glas beads as a cost effective and environmentally friendly filter medium
    • Can be easily adapted to the needs of various industrial sectors
  • Light-Driven Microdrones

    B81064

    Light-Driven Microdrones

    • Innovative approach to micromanipulation and -assembly
    • Easy steering with little specialist knowledge
    • Applicable in a wide and diverse range of laboratory settings
  • Auxetic Diameter Regulator

    Y21003

    Auxetic Diameter Regulator

    • Innovative active gap-control mechanism for gas turbines
    • Increased gas-turbine efficiency due to reduced secondary air flow
    • Simple and space-saving design
  • Double Sensor TLP with high time domain resolution

    Y20007

    Double Sensor TLP with high time domain resolution

    • Transient behavior analysis method for power electronics devices
    • Resolution << 1 ns, pulse duration not restricted (>> 10 ns)
    • TLP / vf-TLP add-on procedure with innovative data analysis algorithm
  • Lab on a Chip for rapid testing applications

    B79091

    Lab on a Chip for rapid testing applications

    • Rapid detection of bio-chemical substances in fluids
    • Easy and fast – requires only small amount of testfluid
    • No sample preparation needed
  • Natural Antioxidants for food or cosmetic oils and fats

    B78099 | B79090

    Natural Antioxidants for food or cosmetic oils and fats

    • Highly effective, edible natural antioxidants for oils and fats
    • Antioxidant and antibacterial effects for long shelf life
    • For edible oils and fats, cosmetics and other oil-based products
  • Double cutting disc with curved deformation lines

    B76166

    Double cutting disc with curved deformation lines

    • Resonance frequency of the inventive cutting disc shifted to rotational speeds > 30% higher compared to state of the art
    • Kinetic energy increased by 75%
    • Cutting disc can safely be operated at higher rotational speed and longer lifetime
  • Plastics: Polymeric Spider Silk Fibers

    B78127

    Plastics: Polymeric Spider Silk Fibers

    • Technical spider silk, ready for mass production
    • High toughness and tensile strength, light weight
    • Cost-efficient electrospinning from polyacrylnitril (PAN)
  • TMEM16A inhibitors as a treatment option for cystic fibrosis

    B78025

    TMEM16A inhibitors as a treatment option for cystic fibrosis

    • TMEM16A inhibitors represent a causal treatment for cystic fibrosis
    • They reduce both excessive mucus formation and airway contraction
    • Repurposing possible: TMEM16A inhibitors include FDA-approved and well-tolerated drugs
  • Hydrophobic mortar

    B75015

    Hydrophobic mortar

    • Hydrophobicity based on bacterial biofilm supplements
    • No need for post-treatment
    • Environmentally friendly
  • Point-of-care blood test for early sepsis diagnosis

    B79000

    Point-of-care blood test for early sepsis diagnosis

    • Diagnostic test for suspected sepsis (bacterial, viral incl. SARS-CoV, fungal)
    • Easy and broadly applicable test, small blood sample volumes needed
    • Allows much earlier diagnosis (~36h) than currently possible
  • Natural Antioxidants for food or cosmetic oils and fats

    B78099, B79090

    Natural Antioxidants for food or cosmetic oils and fats

    • Natural, highly effective and non-toxic active ingredients
    • Active ingredients commercially available at very low cost
    • Stronger stabilization than petrochemical benchmark antioxidants
  • Antilock Braking System (ABS) for bicycles

    B77080

    Antilock Braking System (ABS) for bicycles

    • Energy self-sufficient bicycle ABS
    • All system components encapsulated in the front wheel hub
    • Compatible with standard mechanical and hydraulic disc brakes
  • Economical mosfet-multi-level-converter

    B77014

    Economical mosfet-multi-level-converter

    • Economical MOSFET-based Power Converter
    • High Efficiency Electromobility
    • Broad Range and Flexibility of Conversion Applications
  • Protein Purification/Immobilization through negPeps

    B76080

    Protein Purification/Immobilization through negPeps

    • NegPeps (magnetic particle binding peptides) are novel peptides with the potential to replace the common affinity tags based protein purification/immobilization
    • NegPeps bind to magnetic nanoparticles in a reversible and controlled manner
    • No specific surface functionalization necessary
  • NF-κB-activated dendritic cells

    B71259

    NF-κB-activated dendritic cells

    • that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
    • DCs activation is mediated by via mRNA transfection
    • Activated DCs lead to strong expansion of memory T cells and are much more stable than other DC vaccination products
  • 3D scattering tensor based on one or two axes of rotation

    B76005

    3D scattering tensor based on one or two axes of rotation

    • Shorter acquisition time and faster reconstruction procedure
    • Full scattering tensor with multiple independent structural parameters for each volume element
    • Visualizing sub-pixel fiber orientations
  • Process for the production of alcohols

    B77074

    Process for the production of alcohols

    • Synthesis gas (e.g. CO, CO2, H2) is converted by microorganisms in a bioreactor
    • cascade of two serially connected stirred-tank reactors
    • Utilization for small application as well as for industrial scale up

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