LIFE SCIENCES

Method for assessing the efficacy of immunmodulatory drugs

Apr 1, 2019

| Reference: 

B74042

• Biomarker using CD147/MCT1 destabilization as mechanism

• For the use of IMiDs (Immunomodulatory drugs)

• To treat hematologic malignancies like multiple myeloma (MM)

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PROGNOSTIC AND PREDICTIVE BIOMARKER FOR MELANOMA

Mar 29, 2019

| Reference: 

B78091

• Prognostic test for patients with malignant melanoma
• Estimates patient life expectancy
• Biomarker for predicts melanoma therapy response

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FUEL AND ADDITIVES FOR BIOFUEL FORMULATION

Mar 14, 2019

| Reference: 

B77015, B77099, B78099

• Green fuel with improved combustion and viscosity/freezing point
• Lower particulates and exhaust gas emissions compared to petroleum diesel
• Highly effective, non-toxic natural antioxidants for long storage life

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PROCESS FOR THE SYNTHESIS OF PHB BIOPLASTICS

Mar 6, 2019

| Reference: 

B77105

• Biocompatible and biodegradable plastic with superior properties
• Suitable for packaging, surface coating and polymer blends
• Competitive green substitute for petrochemical plastics

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NEW CATALYST SYSTEM FOR HIGH PERFORMANCE POLYMERS

Mar 6, 2019

| Reference: 

B75246, B74151, B76002, B76107, B76177

• Superior method for the polymerization of Michael-type based monomers
• New versatile catalyst system
• Cheaper, fasterand  greener process

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SUPERHYDROPHOBIC “LOTUS EFFECT” SURFACE COATING

Mar 6, 2019

| Reference: 

B73221

• Superhydrophobic, breathable non-stick coating
• Finishing for varioussurface materials
• Green, organicsolvent-free process  

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ECO-FRIENDLY CHOLINE SURFACTANTS AND DETERGENTS WITH HIGH COLD-WATER SOLUBILITY

Mar 6, 2019

| Reference: 

B69024, B77023

• Highly effective eco-friendly surfactants and detergents
• Low-temp and hard-water robustness
• Cost-effective production from various raw materials

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PROCESS FOR THE ISOLATION OF NATURAL FRAGRANCES

Feb 25, 2019

| Reference: 

B75122

• Fast low-temperature extraction of natural fragrances
• Mild, non-toxic and effective
• Water based green process

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GLYKO-ENGINEERED INTERLEUKIN-4 BASED ANTAGONISTS

Nov 23, 2018

| Reference: 

B77153

  • New strategy for the generation of a novel IL4-based IL4/IL13-Inhibitor
  • Innovative application of N-glycan structures for development of receptor antagonists
  • Applicable for following areas: atopic dermatitis, allergy and allergic asthma
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A CALCIUM-SENSOR FOR NMR/MRI BASED DIAGNOSTIC IMAGING USING HYPERPOLARIZED XENON

Nov 7, 2018

| Reference: 

B75123

  • in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
  • in particular for diagnosing and/or monitoring treatment of diseases
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PH-BIOSENSORS BASED ON HYPERPOLARIZED ZYMONIC ACID FOR NONINVASIVE IMAGING AND SPECTROSCOPY

Oct 30, 2018

| Reference: 

B73167

  • Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
  • Potential for diagnosis and therapy of diseases characterized by aberrant acid-base balances
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SELECTIVE PROTEIN KINASE INHIBITORS TARGETING EPHA2

Oct 17, 2018

| Reference: 

B76157

  • novel EphA2 kinase inhibitors that borrow the chemical scaffold of the drug Dasatinib
  • higher selectivity compared to the existing non-designated alternatives l
  • less likely to be accompanied by side effects arising from off-target inhibition
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AMYLOID INHIBITORY PEPTIDES FOR ALZHEIMER`S DISEASE AND DIABETES

Oct 17, 2018

| Reference: 

B78094

  • macrocyclic peptides (MCIPs): novel class of nanomolar amyloid inhibitors of both Aβ40(42) and IAPP or of Aβ40(42) alone
  • candidates/leads for macrocyclic peptide‐based anti‐amyloid drugs
  • scaffolds for the design of small‐molecule peptidomimetics for targeting amyloidogenesis
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IMMUNOTHERAPY FOR CHRONIC LIVER DISEASES

Sep 3, 2018

| Reference: 

B72272

  • Novel vaccination strategy against chronic liver diseases through stimulation of IMATEs with TLR9-L
  • IMATEs are an anatomic compartment within the liver tissue consisting of myeloid cells
  • iMATEs overcome regulatory cues that limit immune response during chronic liver infections
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A CONVERTIBLE MULTI-PURPOSE BIOREACTOR

May 4, 2018

| Reference: 

B76089

  • ‍Convertible multi-purpose bioreactor provides 4in1 combination of different types of bioreactosr:
  • stirred-tank bioreactor
  • gas-lift bioreactor
  • packed-bed biofilm reactor
  • trickling filter biofilm reactor
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PROCESS FOR THE PRODUCTION OF ALCOHOLS

Apr 16, 2018

| Reference: 

B77074

  • Synthesis gas (e.g. CO, CO2, H2) is converted by microorganisms in a bioreactor 
  • cascade of two serially connected stirred-tank reactors 
  • Utilization for small application as well as for industrial scale up
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SPECIFIC IMAGING AGENTS FOR PRIMARY ALDOSTERONISM DIAGNOSTICS

Mar 23, 2018

| Reference: 

B76123

  • non-invasive differentiation between bilateral hyperplasia and unilateral adenoma by PET-imaging
  • radiolabeled aldosterone synthase (CYP11B2) inhibitors with high selectively, easy synthesis and high chemical and metabolic stability
  • alternative for the so far performed invasive diagnostic adrenal vein sampling in combination with cross-sectional imaging
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SUCCESS PREDICTION OF AN ALLERGEN SPECIFIC IMMUNOTHERAPY

Mar 23, 2018

| Reference: 

B76137

  • Innovative prediction method for the therapeutic success of an allergen-specific immunotherapy (AIT) at an early stage
  • straightforward and easy determination of the relevant parameters from nasal sample material
  • patient-friendly and economic
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MOBILIZING BROWN FAT THERMOGENESIS

Nov 25, 2017

| Reference: 

B75239

  • Endogenously occuring natural peptide
  • Non-adrenergic activator
  • Increasing negative energy
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LOCAL IMMUNE CHECKPOINT INHIBITION

Nov 13, 2017

| Reference: 

B75080

  • Trispecific molecules (LiCADs, local inhibitor checkpoint antibody derivatives) enable local (tumor) immune checkpoint inhibition, which avoids systemic side effects
  • LiCADs comprise binding sites with specificity for a tumor cell, for an effector cell and for a checkpoint molecule
  • Checkpoint binding is restricted and concentrated to tumor cells avoiding undesired toxicity to healthy cells and accordingly systemic side effects
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HYDROPHOBIC MORTAR

Nov 13, 2017

| Reference: 

B75015

  • Mortar hybrid material with superior characteristics: strong hydrophobic properties, no need for post-treatment, not harmful to the environment
  • Supplementation of a bacterial biofilm leads to an increased roughness on the microscale and the nanoscale, and on both the outer and inner surface, imitating the lotus effect
  • Lyophilized powder of the bacterial biofilm available as dry admixture
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NF-κB-ACTIVATED DENDRITIC CELLS

Nov 13, 2017

| Reference: 

B71259

  • Novel DC-vaccination strategy for cancer immunotherapy that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
  • DCs activation is mediated by triggering their NF-κB-pathway via mRNA transfection
  • Activated DCs show increased IL-12 production, have the capacity to repetitively stimulate and expand antigen-specific CTLs, lead to strong expansion of effector T cells (memory T cells) and are much more stable compared to other DC vaccination products
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URINARY MARKER FOR BLADDER CANCER DETECTION

Nov 13, 2017

| Reference: 

B71211

  • The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
  • LASP-1 overcomes the limitation of currently used cystoscopy and urine cytology for diagnosis of UCB
  • LASP-1 is detected in voided urine sediment of bladder cancer patients and is combinable with a second marker to further raise specificity/sensitivity
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PROCESS FOR ISOLATION OF ODORIFEROUS AGENTS

Oct 27, 2017

| Reference: 

B75122

  • Gentle method for isolation of odoriferous agents
  • Almost complete extraction 
  • Extraction within a short time and moderate temperatures
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HIGHLY ACTIVE AND SELECTIVE LIGANDS FOR INTEGRIN avß6

Oct 27, 2017

| Reference: 

B75165

  • Highly upregulated avß6 in different types of cancer
  • Peptides with remarkable affinity and high selctivity
  • No binding affinity toward other RGD-recognizing integrins
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VSV/NDV HYBRID VIRUS CANCER THERAPY

Sep 3, 2018

| Reference: 

B75267

  • ‍VSV/NDV hybrid enables efficient tumor cell killing.
  • VSV/NDV hybrid virus effectively overcomes the safety concerns of each parental virus and
  • combines the advantages of both vesicular stomatitis virus (VSV) and Newcastle disease virus (NDV) vectors
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HYDROGELS: INJECTABLE DEPOT-SYSTEMS

Sep 18, 2018

| Reference: 

B76151

  • that gelatinize by a dual mechanism based on Diels-Alder reaction and physical crosslinking
  • Stability and stiffness can be adjusted to therapeutic need
  • Hydrogels are stable, in situ forming, non-toxic and particularly suitable for controlled drug release
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PROTEIN PURIFICATION/IMMOBILIZATION THROUGH NEG-PEPS

Sep 16, 2017

| Reference: 

B76080

  • NegPeps (magnetic particle binding peptides) are novel peptides with the potential to replace the common affinity tags based protein purification/immobilization 
  • NegPeps bind to magnetic nanoparticles in a reversible and controlled manner
  • No specific surface functionalization necessary 
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MODIFIED BNC FOR CHIP CARDS AND MEDICINE

Sep 3, 2018

| Reference: 

B76007

  • Novel chip technology that can be used as a data storage system, as a computer chip or a wearable
  • Principle: modification of bacterial nanocellulose (BNC) with light-gated DNA-Polymerases and other components 
  • Enables information read in and read out by using DNA, Polymerases and Exonucleases
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NEW PROCESS FOR HIGH PERFORMANCE POLYMERS

Sep 16, 2017

| Reference: 

B75246

  • Synthesis of known polymers to be simpler and more cost-effective 
  • Conversion of monomers which until now have not yet been polymerized by conventional methods 
  • Highly active catalyst
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WET-LAID MEETS ELECTROSPINNING

Sep 16, 2017

| Reference: 

B74211

  • Milder to skin compared to sodium dodecyl sulfate (SDS), in combination with a reduced sensitivity to water hardness
  • Low production costs compared to ethoxylated anionic surfactants
  • Enhanced washing ability and solubilizing power due to high water solubility
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NEW DRUG TARGET IN ALZHEIMER‘S DISEASE

Sep 16, 2017

| Reference: 

B74174

  • Aη-α as a new drug target and / or diagnostic marker for Alzheimer disease
  • Presence of Aη-α fragments in AD brains should be taken into account for development/applicati- on of drugs targeting Aβ or inhibiting β-secretase, since these lead to accumulation of Aη-α
  • Antibodies to detect η-secretase pathway peptides are available
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ONE-POT PROCEDURE FOR NCC ISOLATION

Sep 3, 2018

| Reference: 

B74068

  • ‍Conventional Production of NCC is complex, expensive and takes several days
  • Novel simplified method for NCC isolation: neutralization-based isolation
  • Significantly enhanced yield, accelerated process and reduced water usage
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A NEW TARGET IN CANCER THERAPY

Sep 16, 2017

| Reference: 

B74064

  • Cancer cells use an extracellular citrate supply as an important energy source and substrate for the synthesis of critical cellular building blocks (e.g. fatty acids). 
  • A highly specialized plasma membrane protein (pmCiC, plasma membrane citrate carrier) was found to be responsible for citrate uptake in cancer cells
  • pmCiC is a novel and specific marker and therapeutic target for cancer cells
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HYDRODABCYL: A HYDROPHILIC DARK QUENCHER

Sep 16, 2017

| Reference: 

B74047

  • ‍Hydrodabcyl: A hydrophilic alternative to the commonly used dark quencher Dabcyl
  • Non-immunogenic and non-toxic
  • Perfectly suitable for a large variety of biological and biochemical systems
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SMALL MOLECULE HDAC6 INHIBITORS

Sep 16, 2017

| Reference: 

B73271

  • ‍HDAC6 is a promising target for the treatment of chronic immune and inflammatory disorders such as rheumatoid arthritis (RA)
  • Marbostat are new small molecule inhibitors of HDAC6 with superior characteristics: in comparison to the established HDAC6 inhibitor Tubastatin A, the new inhibitors are more potent and specific, and most importantly they highly and selectively inhibit the enzyme activity of HDAC6 without destroying the protein.
  • Provision of a viable alternative to first line NSAIDs (non-steroidal anti-inflammatory drugs) in the treatment of RA
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IMPROVING STABILITY AND SECRETION OF ANTIBODIES

Sep 16, 2017

| Reference: 

B73076

  • Improvement of the biophysical properties of antibodies and enhancement of antibody secretion by imitating the stabilizing structural elements of shark antibodies
  • CL domain is modified by a conservative exchange of amino acids at two positions
  • Compared to the wild type CL, the melting point of the modified CL domain is almost 10°C higher and its stability against urea-induced denaturation is also markedly increased 
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NEW SEROTONIN RECEPTOR AGONISTS

Sep 16, 2017

| Reference: 

B72118

  • New serotonin receptor 5HT1P agonists (5-Benzyloxyindalpine, 5 BOIP) for the treatment or prevention of GI diseases such as constipation and functional dyspepsia and, in particular, for relieving GI symptoms
  • In the proximal stomach, 5BOIP evokes muscle relaxation, thereby improving the gastric accommodation reflex
  • 5 BOIP is highly specific, extremely stable against hydrolysis and oxidation and is much more convenient in production than other known agonists
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SMALL MOLECULE INHIBITORS OF CD40-TRAF6 INTERACTIONS

Sep 16, 2017

| Reference: 

B72031

  • New selective inhibitors for treatment of chronic inflammatory diseases, such as atherosclerosis, obesity and multiple sclerosis
  • Inhibitors selectively block CD40-TRAF6 interactions
  • The selective blockage of the CD40-TRAF6 interactions strongly reduces inflammation, whereas unwanted immune-suppressive side effects are reduced
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CHOLINE COMPOUNDS AND THEIR USE AS SURFACTANTS

Sep 16, 2017

| Reference: 

B69024

  • Milder to skin compared to sodium dodecyl sulfate (SDS), in combination with a reduced sensitivity to water hardness
  • Low production costs compared to ethoxylated anionic surfactants
  • Enhanced washing ability and solubilizing power due to high water solubility
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