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  • Success Prediction of an Allergen- specific Immunotherapy

    B76137

    Success Prediction of an Allergen- specific Immunotherapy

    • Innovative prediction method for the therapeutic success of an allergen-specific immunotherapy (AIT) at an early stage
    • straightforward and easy determination of the relevant parameters from nasal sample material
    • patient-friendly and economic
  • NF-κB-activated dendritic cells

    B71259

    NF-κB-activated dendritic cells

    • that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
    • DCs activation is mediated by via mRNA transfection
    • Activated DCs lead to strong expansion of memory T cells and are much more stable than other DC vaccination products
  • Improving Stability and Secretion of ­Antibodies

    B73076

    Improving Stability and Secretion of ­Antibodies

    • Improvement of the biophysical properties of antibodies and enhancement of antibody secretion by imitating the stabilizing structural elements of shark antibodies
    • CL domain is modified by a conservative exchange of amino acids at two positions
    • Compared to the wild type CL, the melting point of the modified CL domain is almost 10°C higher and its stability against urea-induced denaturation is also markedly increased
  • Small molecule inhibitors of CD40-TRAF6 ­interactions

    B72031

    Small molecule inhibitors of CD40-TRAF6 ­interactions

    • New selective inhibitors for treatment of chronic inflammatory diseases, such as atherosclerosis, obesity and multiple sclerosis.
    • Inhibitors selectively block CD40-TRAF6 interactions
    • The selective blockage of the CD40-TRAF6 interactions strongly reduces inflammation, whereas unwanted immune-suppressive side effects are reduced

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