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• Practical and safe fluorination of white phosphorus (P4)

  B82082

  Practical and safe fluorination of white phosphorus (P4)

  • One-pot reactions with simple and commercially available reagents
  • Safe fluorination, no hazardous educts, intermediates or waste
  • Sustainable closed-loop or (electro-)catalytic reactions routes possible
• Isothiocyanates as anti-thrombotics and thrombolytics

  B84012

  Isothiocyanates as anti-thrombotics and thrombolytics

  • The isothiocyanates AITC, BITC and PEITC prevent platelet activation and reverse aggregation.
  • The ITCs have potential as therapeutic and preventive drugs for thromboembolic conditions.
  • ITCs are small molecules and can be produced cost-effectively and are highly stable.
• TMEM16A inhibitors as a Polycystic kidney disease (PKD) treatment option

  B79076

  TMEM16A inhibitors as a Polycystic kidney disease (PKD) treatment option

  • TMEM16A inhibitors include approved and well-tolerated drugs such as niclosamide and benzbromarone
  • Significant suppression of renal cysts
  • Combinable with other strategies
• Sustainable phosphorus functionalization with disulfides

  B82082

  Sustainable phosphorus functionalization with disulfides

  • One-pot reactions with simple, cheap reagents to obtain valuable monophosphorus compounds
  • Sustainable closed-loop or (electro-)catalytic reactions routes possible
  • High process safety: no hazardous educts, intermediates or by-products
• New linker for Protein A boosts binding capacity

  B84062

  New linker for Protein A boosts binding capacity

  • Rigid inter-domain linker enhances the accessibility of individual Protein A binding sites
  • Simple way to boost binding capacity of Protein A resins 1.5 to 2-fold
  • Potential to reduce costs and increase productivity in downstream platform processes
• Apnea Treat- a minimally invasive implant for Sleep apnea therapy

  B83003

  Apnea Treat- a minimally invasive implant for Sleep apnea therapy

  • Treating sleep apnea without the need for patient compliance
  • Minimal tissue damage, no discomfort to be expected
  • Low manufacturing costs for the implant system
• A device for bleeding control in pelvic fractures

  B78145

  A device for bleeding control in pelvic fractures

  • Transurethral catheter device for the emergency treatment ofpatients with unstable pelvic fractures
  • Rapidly controls the bleeding by reducing the intrapelvic volume
  • Combinable with other treatment strategies
• The link between cardiac disease and sleepless nights

  B82005 / B83116

  The link between cardiac disease and sleepless nights

  • Underlying defective melatonin secretion in cardiac patients
  • Early anti-inflammatory intervention prevent fibrotic scarring
  • SCG hypertrophy as biomarker
• Carbon nanofiber electrodes for use in lateral flow assays

  B81092

  Carbon nanofiber electrodes for use in lateral flow assays

  • Easy on-site analsysis for consumers at home maintained
  • Higher sensitivity and more quantitative measurement
  • Microfluidic systems planned
• Cytosolic RNA depletion by polymeric nanoparticles

  B83117

  Cytosolic RNA depletion by polymeric nanoparticles

  • Mucin nanoparticles cross-linked with anti-miRNA oligonucleotides
  • Treating systemic diseases associated with increased cellular RNA levels
  • Depletion of miRNA-21 reduced tumor growth in vivo by 50%
• A Biomarker for Post-COVID Syndrome

  B83046

  A Biomarker for Post-COVID Syndrome

  • Simplified diagnosis of Post-Covid
  • Identification of PCS-specific SARS-CoV-2 S-protein epitopes
  • Demonstrated feasibility of high-throughput screening
• Novel clinical biomarker for hepatic steatosis

  B82088

  Novel clinical biomarker for hepatic steatosis

  • Applicable for detecting or grading hepatic steatosis
  • Fast, simple and inexpensive
  • Minimal non-invasive
• BICEP: A Bio- Inspired Compliant Elbow Prosthesis

  B82103

  BICEP: A Bio- Inspired Compliant Elbow Prosthesis

  • Compact and bio-inspired joint design with soft properties
  • Compliant behavior in both the sagittal and transversal planes
  • Safe absorption of unintentional impacts
• Puncturing system for a safer tracheostomy

  B81019

  Puncturing system for a safer tracheostomy

  • Enables the physician to reliably identify the correct site and trajectory of the puncturing instrument
  • Especially suited for patients with a challenging anatomy (e.g obese tissue, goiter, short neck)
  • PDT significantly decreases costs, time and manpower requirements
• Grainstorm revolutionizes the ethanolic fermentation of starchy raw materials in the production of distilled spirits and simplifies starch-based fermentation

  B81132

  Grainstorm revolutionizes the ethanolic fermentation of starchy raw materials in the production of distilled spirits and simplifies starch-based fermentation

  • Mashing takes place at low temperatures with a dispersing device (up to 32°C)
  • No need for cooling the mash, fermentation at mashing temperature
  • Complete conversion of starch, very high yields
  • Greatly simplified process execution, significant savings in equipment and mashing time
• Peptide agent against multi-resistant bacteria

  B81112

  Peptide agent against multi-resistant bacteria

  • antibacterial agent for multi drug resistant Gram-negative infections
  • fast action (hours), also bactericidal against non-replicating bacteria
  • especially for patients with autoantibodies against endogenous BPI
• LINAC Cavities Made by Additive Manufacturing

  Y20000

  LINAC Cavities Made by Additive Manufacturing

  • Relevant reduction of manufacturing costs
  • Freedom in cavitiy design due to additive manufacturing
  • Optimized cavity geometries reduce LINAC operating costs while increasing operating time and lifetime
  • Innovation can be used in particle accelerators for e.g. radiation therapy, cargo scanning or food
• New catalysts for the production of superior PHB

  B82063

  New catalysts for the production of superior PHB

  • Biocompatible and biodegradable plastic with superior material properties compared to bacterial PHB
  • Cost-effective production via ring opening polymerization of ß‐butyrolactone
  • Thermomechanical properties similar to petrochemical PP, material suitable for melt processing
• Novel coating of catheter-based cardiac devices

  B79124

  Novel coating of catheter-based cardiac devices

  • Scar tissue as a central problem after stent implantation
  • Local coating of cardiac devices inhibits re-narrowing of vessel
  • Dual anti-proliferative and anti-migratory effect on cells
• The T-Cell-Therapy Success Code: Signatures of recent T-cell activation allow isolation of highly functional tumor-specific T cell receptors

  B81078

  The T-Cell-Therapy Success Code: Signatures of recent T-cell activation allow isolation of highly functional tumor-specific T cell receptors

  • Cost-effective isolation of highly functional tumor-specific TCRs
  • Method using predictive markers to identify TCRs of high functional quality
  • Isolation of TCRs from easily accessible peripheral blood
• PosH-Tag: Cost effective and highly specific biomolecule separation with bare silica surfaces and immobilization using bare magnetic iron-oxide nanoparticles

  B80037

  PosH-Tag: Cost effective and highly specific biomolecule separation with bare silica surfaces and immobilization using bare magnetic iron-oxide nanoparticles

  • Platform for protein purification and immobilization
  • Efficient and cost effective separation of target molecules
  • Without NTA modification and the use of imidazole
• New cell therapy cures metastatic cancer in mouse

  B81137

  New cell therapy cures metastatic cancer in mouse

  • New RESURRECT NK and T cell therapy cures metastatic cancer in mouse
  • RESURRECT T and NK cells overcome immunosuppression in tumors and metastases
  • RESURRECT cells are effective in tumors resistant to standard immunotherapies
• Novel approach for disruption of pubic symphysis

  B80189

  Novel approach for disruption of pubic symphysis

  • Trauma accidents often result in life threatening pelvic injuries
  • 2 component cable-clamp implant for disrupted pubic symphysis
  • Fewer complications compared to conventional approach
• Implant and implant applicator for endoscopic and customizable anastomosis

  B80080

  Implant and implant applicator for endoscopic and customizable anastomosis

  • System for endoluminal anastomosis
  • Adjustable to the lumen size of the patient’s intestine
  • Force application mechanism at flexible endoscope tip for arbitrary shapes
• Nanoparticles for the targeted treatment of neovascular ocular diseases

  B79130

  Nanoparticles for the targeted treatment of neovascular ocular diseases

  • systemic therapy instead of intravitreal antibody injections
  • a single systemic injection cured retinopathy of prematurity in mouse model
  • causal treatment of all neovascular ocular diseases
• Lab on a Chip for rapid testing applications

  B79091

  Lab on a Chip for rapid testing applications

  • Rapid detection of bio-chemical substances in fluids
  • Easy and fast – requires only small amount of testfluid
  • No sample preparation needed
• Natural Antioxidants for food or cosmetic oils and fats

  B78099 | B79090

  Natural Antioxidants for food or cosmetic oils and fats

  • Highly effective, edible natural antioxidants for oils and fats
  • Antioxidant and antibacterial effects for long shelf life
  • For edible oils and fats, cosmetics and other oil-based products
• Liposome-encapsidated bioactive hexapeptides for targeted pancreatic cancer therap

  B80078

  Liposome-encapsidated bioactive hexapeptides for targeted pancreatic cancer therap

  • Targeted tumor therapy for highly aggressive pancreatic cancers
  • Particularly suited for combinational therapy
  • Targeted therapies for human solid tumors bearing wild-type TP53
• Sustainable one-pot preparation of versatile organo-phosphorus compounds

  B79039

  Sustainable one-pot preparation of versatile organo-phosphorus compounds

  • Simple one-pot reaction using mild, non-corrosive conditions
  • Reaction yields e.g. stannyl phosphines for direct reaction with electrophiles
  • No separation/purification steps necessary
• TMEM16A inhibitors as a treatment option for cystic fibrosis

  B78025

  TMEM16A inhibitors as a treatment option for cystic fibrosis

  • TMEM16A inhibitors represent a causal treatment for cystic fibrosis
  • They reduce both excessive mucus formation and airway contraction
  • Repurposing possible: TMEM16A inhibitors include FDA-approved and well-tolerated drugs
• Virus-mimetic nanoparticles for diabetic nephropathy

  B79122

  Virus-mimetic nanoparticles for diabetic nephropathy

  • Specific drug delivery via nanoparticles
  • Virus like targeting in a two-stage process
  • Dose reduction compared to free drug
• Innovative solid-liquid reactor for high-speed mass transfer & catalysis without clogging

  B78159

  Innovative solid-liquid reactor for high-speed mass transfer & catalysis without clogging

  • Fully scalable rotating reactor for quick mass transfer reactions
  • Broad variety of chemical- and pharmaceutical applications such as extraction & biocatalysis
  • Especially effective for the use of small or deformable particles as solid reactant (no clogging)
• Reducing waste and time – Novel approach allows for rapid isotope production for medical diagnostics

  B78139

  Reducing waste and time – Novel approach allows for rapid isotope production for medical diagnostics

  • ⁹⁹ᵐTc as one of the most important medical radioisotopes
  • Novel dry-chemical separation of molybdenum and uranium
  • More environmentally friendly production with less toxic waste
• Innovative braiding technique and bifurcation stents with a seamless transition area

  B78126

  Innovative braiding technique and bifurcation stents with a seamless transition area

  • Optimized braiding technique for bifurcation stents
  • Seamless transition area with a homogenous density for maximum stability and flexibility at bifurcation sites
  • Secondary branches can be produced simultaneously
• Tau aggregation inhibiting peptides as a basis for future therapies for tauopathies

  B79054

  Tau aggregation inhibiting peptides as a basis for future therapies for tauopathies

  • Tau aggregation inhibiting peptides
  • Strongly bind to tau monomers, -oligomers and -fibrils
  • Suitable for future tauopathy therapies
• Point-of-care blood test for early sepsis diagnosis

  B79000

  Point-of-care blood test for early sepsis diagnosis

  • Diagnostic test for suspected sepsis (bacterial, viral incl. SARS-CoV, fungal)
  • Easy and broadly applicable test, small blood sample volumes needed
  • Allows much earlier diagnosis (~36h) than currently possible
• Natural Antioxidants for food or cosmetic oils and fats

  B78099, B79090

  Natural Antioxidants for food or cosmetic oils and fats

  • Natural, highly effective and non-toxic active ingredients
  • Active ingredients commercially available at very low cost
  • Stronger stabilization than petrochemical benchmark antioxidants
• Multifunctional Anti-Amyloid Peptides

  B78094 / B82009 / B84076

  Multifunctional Anti-Amyloid Peptides

  • Macrocyclic peptides with drug-like properties
  • Highly potent inhibitors of Aβ amyloid self-assembly
  • Promising in vivo data from Alzheimer’s mouse model
• Protein Purification/Immobilization through negPeps

  B76080

  Protein Purification/Immobilization through negPeps

  • NegPeps (magnetic particle binding peptides) are novel peptides with the potential to replace the common affinity tags based protein purification/immobilization
  • NegPeps bind to magnetic nanoparticles in a reversible and controlled manner
  • No specific surface functionalization necessary
• Rotating reactor for heterogeneous ­transfer of substances

  B78159

  Rotating reactor for heterogeneous ­transfer of substances

  • Reactor for mass transfer reactions
  • Biotech, food and beverage processing
  • For small or deformable particles
• NF-κB-activated dendritic cells

  B71259

  NF-κB-activated dendritic cells

  • that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
  • DCs activation is mediated by via mRNA transfection
  • Activated DCs lead to strong expansion of memory T cells and are much more stable than other DC vaccination products
• Flexible and breathable nonwovens with superior electrical conductivity

  B76140

  Flexible and breathable nonwovens with superior electrical conductivity

  • Bendable and breathable material with metal-like electrical conductivity
  • Low silver content required, simple wet-laid process
  • For e.g. lightweight electrodes and electric shielding
• Innovative ceramic fiber composite materials with high thermal and corrosion stabilities

  B74087, B76032

  Innovative ceramic fiber composite materials with high thermal and corrosion stabilities

  • Superior ceramic fiber prepregs for high-temperature stable materials
  • Prepregs storable without climate control, reversible drying process
  • Little to no volume shrinkage during sintering

43 of 89 Tech Offers