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  • Amyloid Inhibitory Peptides for Alzheimer’s Disease and Diabetes

    B78094

    Amyloid Inhibitory Peptides for Alzheimer’s Disease and Diabetes

    • macrocyclic peptides (MCIPs): novel class of nanomolar amyloid inhibitors of both Aβ40(42) and IAPP or of Aβ40(42) alone
    • candidates/leads for macrocyclic peptide‐based anti‐amyloid drugs
    • scaffolds for the design of small‐molecule peptidomimetics for targeting amyloidogenesis
  • New drug target in Alzheimer’s disease

    B74174

    New drug target in Alzheimer’s disease

    • Aη-α as a new drug target and / or diagnostic marker for Alzheimer’s disease
    • Inhibition of β-secretase leads to accumulation of Aη-α
    • Antibodies to detect η-secretase pathway peptides are available

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