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• Advanced Radio-guided Surgery: Tc-99m-labelled Nanoparticles for the Detection of Sentinel Lymph Nodes

  B82027

  Advanced Radio-guided Surgery: Tc-99m-labelled Nanoparticles for the Detection of Sentinel Lymph Nodes

  • Radio-guided Surgery
  • Radiopharmaceutical
  • Nanotechnology
• The T-Cell-Therapy Success Code: Signatures of recent T-cell activation allow isolation of highly functional tumor-specific T cell receptors

  B81078

  The T-Cell-Therapy Success Code: Signatures of recent T-cell activation allow isolation of highly functional tumor-specific T cell receptors

  • Cost-effective isolation of highly functional tumor-specific TCRs
  • Method using predictive markers to identify TCRs of high functional quality
  • Isolation of TCRs from easily accessible peripheral blood
• RESURRECT NK cells cure metastatic cancer in mouse models

  B81137

  RESURRECT NK cells cure metastatic cancer in mouse models

  • Effective cure from advanced metastatic cancer in mouse models
  • Broadly applicable: metastasis from melanoma, colorectal and pancreatic cancer, etc.
  • Allogeneic setting allows off-the-shelf use
• Anti-PSMA antibodies for therapeutic and diagnostic purposes

  B80048

  Anti-PSMA antibodies for therapeutic and diagnostic purposes

  • Anti-PSMA antibody with sub-nanomolar affinity high specificity for native PSMA and good thermal stability
  • Pre-clinical optimization for developability
  • Among others, suitable for antibody-drug-conjugates, photodynamic therapy or imaging
• Drug repurposing: Beta-lactam antibiotic with high efficacy against colorectal cancer

  B80177

  Drug repurposing: Beta-lactam antibiotic with high efficacy against colorectal cancer

  • Re-purposing: beta-lactam antibiotic for cancer treatment
  • Promising animal data for colorectal cancer in various stages, ongoing research for additional solid cancers
  • E.g. for combination with existing cancer therapies, very low side effects
• Liposome-encapsidated bioactive hexapeptides for targeted pancreatic cancer therap

  B80078

  Liposome-encapsidated bioactive hexapeptides for targeted pancreatic cancer therap

  • Targeted tumor therapy for highly aggressive pancreatic cancers
  • Particularly suited for combinational therapy
  • Targeted therapies for human solid tumors bearing wild-type TP53
• Innovative 3D cell culture matrix with tunable properties

  B79074

  Innovative 3D cell culture matrix with tunable properties

  • New Matrix for 3D cell culture preparation
  • Cost-effective material with defined material properties
  • Allows free design of culture conditions
• Innovative 18F-labeled Norepinephrine analog PET tracers for broad diagnostic applications in neurology, cardiology and oncology

  B78129

  Innovative 18F-labeled Norepinephrine analog PET tracers for broad diagnostic applications in neurology, cardiology and oncology

  • Simple and low-cost synthesis and superior labeling efficiency
  • Extended tracer half-life and high PET signal strength
  • Widely applicable in neurology, oncology and cardiology
• Efficacy boost for dendritic cell therapies

  B73083

  Efficacy boost for dendritic cell therapies

  • Method to increase efficacy of existing DC-based cell therapies
  • Enzymatic treatment improves T-cell priming capacity up to 10-fold
  • Results in strong proliferation of tumor-killing T-cells
• Highly promising AML therapy, curative in mouse model

  B78209

  Highly promising AML therapy, curative in mouse model

  • Highly effective therapy for Acute Myeloid Leukemia (AML)
  • Long-lasting elimination of leukemic blasts and leukemic stem cells
  • Suitable for all major AML subgroups, low side effects
• Prognostic and predictive Biomarker for Melanoma

  B78091

  Prognostic and predictive Biomarker for Melanoma

  • Prognostic test for patients with malignant melanoma
  • Estimates patient life expectancy
  • Biomarker for predicts melanoma therapy response

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