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Nov 5, 2020

Sustainable one-pot preparation of versatile organo-phosphorus compounds

Life Sciences, Chemical Process

  • Simple one-pot reaction using mild, non-corrosive conditions
  • Reaction yields e.g. stannyl phosphines for direct reaction with electrophiles
  • No separation/purification steps necessary

Your contact

Dr. Rebecca Kohler

+49 (0) 89 5480177 - 33
Reference Number:


Current industrial production of phosphorus-containing products from P4(which is the source of P atoms for these compounds) requires multiple reaction steps and involves the use of extremely hazardous reagents and intermediates (e.g. PCl3, PH3, Cl2) that are difficult and/or expensive to employ safely. The need for multiple reaction steps has inevitable negative consequences for overall space/time yield and amplifies the formation of waste. It also leads to practical complications, as intermediate products must be isolated and purified prior to subsequent steps.


Our method instead provides industrially relevant phosphorus-containing products in a single step, without the need for tedious or time-consuming isolation of any intermediates. It is simple to implement and avoids the use of especially hazardous or difficult-to-handle reagents.

Commercial Opportunities

Our methodology is likely to be of particular interest to chemical companies working at the ‘fine chemicals’ (rather than ‘bulk chemicals’) end of the industry, where there is less scope to mitigate practical or safety problems through bespoke reactor design, and these concerns are therefore especially acute. Given the wide-ranging uses of phosphorus-containing compounds there are a great many specific areas of potential interest. An application example is the preparation of acylphosphine oxide photoinitiators (MAPOs/BAPOs), and flame retardant precursors (e.g. THPC), for which we have already shown that our method can be used to produce relevant compounds. We are looking for industry partners for further development and/or licensing.

Development Status

The inventors have used the process for preparations in scale of several grams.


Interested? Get in touch!

Contact a specific team member via the Team section or simply use our contact form for your request.

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