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• Innovative 18F-labeled Norepinephrine analog PET tracers for broad diagnostic applications in neurology, cardiology and oncology

  B78129

  Innovative 18F-labeled Norepinephrine analog PET tracers for broad diagnostic applications in neurology, cardiology and oncology

  • Simple and low-cost synthesis and superior labeling efficiency
  • Extended tracer half-life and high PET signal strength
  • Widely applicable in neurology, oncology and cardiology
• Novel heavy metal complexes as ex-vivo contrast agents for computed tomography scanning of biological samples

  B76184 / B76179

  Novel heavy metal complexes as ex-vivo contrast agents for computed tomography scanning of biological samples

  • Novel contrast agents for histological methods
  • Drastic contrast enhancement for CT scanning
  • Facilitation of highly detailed 3D information
• Novel tool for the early diagnosis of sepsis

  B79000

  Novel tool for the early diagnosis of sepsis

  • Diagnostic test for patients with suspected sepsis
  • Easy and broadly applicable test with low amount of blood
  • Allows much earlier diagnosis than currently possible
• Cutting cost and time - HCV immunoassay predicts clinical response rate to antiviral treatment

  B76124

  Cutting cost and time - HCV immunoassay predicts clinical response rate to antiviral treatment

  • Antiviral drugs for HCV are effective but expensive
  • Immunoassay can predict response to antiviral drugs
  • Significant reduction of long-term treatment cost
• New tricks for an old system – Bacterial system enables site-specific ubiquitylation of proteins in living cells

  B78098

  New tricks for an old system – Bacterial system enables site-specific ubiquitylation of proteins in living cells

  • Chemoenzymatic approach to study ubiquitylation
  • Inducible attachment of ubiquitin marks to proteins
  • Method to be applied to other protein modifications
• GRAND-SLAM - The Method for quantification of new and old RNA

  B78083

  GRAND-SLAM - The Method for quantification of new and old RNA

  • Labelling with SLAM-seq, TUC-seq or TLapse-seq
  • Fully quantitative analyses of RNA (incl. single cell)
  • Vertebrates, insects, plants & yeast, in vitro & in vivo
• Urinary marker for bladder cancer detection

  B71211

  Urinary marker for bladder cancer detection

  • The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
  • LASP-1 overcomes the limitation of currently used cystoscopy and urine cytology for diagnosis of UCB
  • LASP-1 is detected in voided urine sediment of bladder cancer patients and is combinable with a second marker to further raise specificity/sensitivity
• Method for assessing the efficacy of immunmodulatory drugs

  B74042

  Method for assessing the efficacy of immunmodulatory drugs

  • Biomarker using CD147/MCT1 destabilization as mechanism
  • For the use of IMiDs (Immunomodulatory drugs)
  • To treat hematologic malignancies like multiple myeloma (MM)
• Prognostic and predictive Biomarker for Melanoma

  B78091

  Prognostic and predictive Biomarker for Melanoma

  • Prognostic test for patients with malignant melanoma
  • Estimates patient life expectancy
  • Biomarker for predicts melanoma therapy response
• A calcium-sensor for NMR/MRI based diagnostic imaging using hyperpolarized xenon

  B75123

  A calcium-sensor for NMR/MRI based diagnostic imaging using hyperpolarized xenon

  • in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
  • in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
• PH-biosensor based on hyper- polarized zymonic acid for non-invasive imaging and spectroscopy

  B73167

  PH-biosensor based on hyper- polarized zymonic acid for non-invasive imaging and spectroscopy

  • Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
  • Potential for diagnosis and therapy of diseases characterized by aberrant acid-base balances
• Small molecule hdac6 inhibitors

  B74064

  Small molecule hdac6 inhibitors

  • Cancer cells use an extracellular citrate supply as an important energy source and substrate for the synthesis of critical cellular building blocks (e.g. fatty acids).
  • A highly specialized plasma membrane protein (pmCiC, plasma membrane citrate carrier) was found to be responsible for citrate uptake in cancer cells
  • pmCiC is a novel and specific marker and therapeutic target for cancer cells

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