Lab on a Chip for rapid testing applications
Lab on a Chip for rapid testing applications
- Rapid detection of bio-chemical substances in fluids
- Easy and fast – requires only small amount of testfluid
- No sample preparation needed
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Lab on a Chip for rapid testing applications
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Novel approach for a non-invasive diagnosis of chronic rhinosinusitis with nasal polyps
Novel approach for a non-invasive diagnosis of chronic rhinosinusitis with nasal polyps
- Pappalysin-A is correlated with polyp growth in CRSwNP
- Non-invasive detection in nasal mucus by commercial kits
- Monitoring of disease-progression and response rate
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When time is of the essence – Novel blood biomarker allows for a fast diagnosis of Type A aortic dissection
When time is of the essence – Novel blood biomarker allows for a fast diagnosis of Type A aortic dissection
- Type A aortic dissection is a medical emergency
- Novel protein biomarker for fast diagnosis
- Easy blood-based testing
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Innovative 18F-labeled Norepinephrine analog PET tracers for broad diagnostic applications in neurology, cardiology and oncology
Innovative 18F-labeled Norepinephrine analog PET tracers for broad diagnostic applications in neurology, cardiology and oncology
- Simple and low-cost synthesis and superior labeling efficiency
- Extended tracer half-life and high PET signal strength
- Widely applicable in neurology, oncology and cardiology
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Novel heavy metal complexes as ex-vivo contrast agents for computed tomography scanning of biological samples
Novel heavy metal complexes as ex-vivo contrast agents for computed tomography scanning of biological samples
- Novel contrast agents for histological methods
- Drastic contrast enhancement for CT scanning
- Facilitation of highly detailed 3D information
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Novel tool for the early diagnosis of sepsis
Novel tool for the early diagnosis of sepsis
- Diagnostic test for suspected sepsis (bacterial, viral incl. SARS-CoV, fungal)
- Easy and broadly applicable test, small blood sample volumes needed
- Allows much earlier diagnosis (~36h) than currently possible
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Cutting cost and time - HCV immunoassay predicts clinical response rate to antiviral treatment
Cutting cost and time - HCV immunoassay predicts clinical response rate to antiviral treatment
- Antiviral drugs for HCV are effective but expensive
- Immunoassay can predict response to antiviral drugs
- Significant reduction of long-term treatment cost
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New tricks for an old system – Bacterial system enables site-specific ubiquitylation of proteins in living cells
New tricks for an old system – Bacterial system enables site-specific ubiquitylation of proteins in living cells
- Chemoenzymatic approach to study ubiquitylation
- Inducible attachment of ubiquitin marks to proteins
- Method to be applied to other protein modifications
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GRAND-SLAM - The Method for quantification of new and old RNA
GRAND-SLAM - The Method for quantification of new and old RNA
- Labelling with SLAM-seq, TUC-seq or TLapse-seq
- Fully quantitative analyses of RNA (incl. single cell)
- Vertebrates, insects, plants & yeast, in vitro & in vivo
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Urinary marker for bladder cancer detection
Urinary marker for bladder cancer detection
- The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
- LASP-1 overcomes the limitation of currently used cystoscopy and urine cytology for diagnosis of UCB
- LASP-1 is detected in voided urine sediment of bladder cancer patients and is combinable with a second marker to further raise specificity/sensitivity
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Method for assessing the efficacy of immunmodulatory drugs
Method for assessing the efficacy of immunmodulatory drugs
- Biomarker using CD147/MCT1 destabilization as mechanism
- For the use of IMiDs (Immunomodulatory drugs)
- To treat hematologic malignancies like multiple myeloma (MM)
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Prognostic and predictive Biomarker for Melanoma
Prognostic and predictive Biomarker for Melanoma
- Prognostic test for patients with malignant melanoma
- Estimates patient life expectancy
- Biomarker for predicts melanoma therapy response
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A calcium-sensor for NMR/MRI based diagnostic imaging using hyperpolarized xenon
A calcium-sensor for NMR/MRI based diagnostic imaging using hyperpolarized xenon
- in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
- in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
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PH-biosensor based on hyper- polarized zymonic acid for non-invasive imaging and spectroscopy
PH-biosensor based on hyper- polarized zymonic acid for non-invasive imaging and spectroscopy
- Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
- Potential for diagnosis and therapy of diseases characterized by aberrant acid-base balances
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