MPS – rapid binding test device
MPS – rapid binding test device
- Fast and highly sensitive evaluation of data
- Measurement results in milliseconds with sub-femto molar sensitivity
- Portable, simple, robust, flexible & cost-effective
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MPS – rapid binding test device
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System and method for generating a traveling field free line
System and method for generating a traveling field free line
- MPI Scanning of 2D & 3D volumes without specimen displacement
- Large field of view and accurate scanning times for MPI applications
- Novel encoding concept enables rapid 3D imaging
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System for the one-sided generation of magnetic fields for the multidimensional encoding of magnetic particles and method of operation thereof
System for the one-sided generation of magnetic fields for the multidimensional encoding of magnetic particles and method of operation thereof
- Magnetic particle imaging for measuring large and small sample volumes
- Low magnetic field strenghts suitable for clinical applications
- Novel encoding concept enables rapid 3D imaging
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Direct Extraction of Astaxanthin from H. pluvialis
Direct Extraction of Astaxanthin from H. pluvialis
- Novel downstream process for natural astaxanthin extraction
- Lower investment costs compared to conventional industrial process
- Opportunity to serve increased consumer demand
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Controlled release of therapeutical agents from polymer brush coatings by employing reversible polymer condensation using ionic cross-linkers
Controlled release of therapeutical agents from polymer brush coatings by employing reversible polymer condensation using ionic cross-linkers
- Surface coat with drug encapsulation for medical implants
- Triggered drug release by contact with physiological salt concentrations
- Quickly achieve therapeutic levels at actual site of inflammation
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Drug repurposing: Beta-lactam antibiotic with high efficacy against colorectal cancer
Drug repurposing: Beta-lactam antibiotic with high efficacy against colorectal cancer
- Re-purposing: beta-lactam antibiotic for cancer treatment
- Promising animal data for colorectal cancer in various stages, ongoing research for additional solid cancers
- E.g. for combination with existing cancer therapies, very low side effects
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Nanoparticles for the targeted treatment of neovascular ocular diseases
Nanoparticles for the targeted treatment of neovascular ocular diseases
- systemic therapy instead of intravitreal antibody injections
- a single systemic injection cured retinopathy of prematurity in mouse model
- causal treatment of all neovascular ocular diseases
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Lab on a Chip for rapid testing applications
Lab on a Chip for rapid testing applications
- Rapid detection of bio-chemical substances in fluids
- Easy and fast – requires only small amount of testfluid
- No sample preparation needed
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Natural Antioxidants for food or cosmetic oils and fats
Natural Antioxidants for food or cosmetic oils and fats
- Highly effective, edible natural antioxidants for oils and fats
- Antioxidant and antibacterial effects for long shelf life
- For edible oils and fats, cosmetics and other oil-based products
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Liposome-encapsidated bioactive hexapeptides for targeted pancreatic cancer therap
Liposome-encapsidated bioactive hexapeptides for targeted pancreatic cancer therap
- Targeted tumor therapy for highly aggressive pancreatic cancers
- Particularly suited for combinational therapy
- Targeted therapies for human solid tumors bearing wild-type TP53
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Influenza-specific T-cell receptor (TCR)
Influenza-specific T-cell receptor (TCR)
- Influenza specific TCR
- Highly conserved epitope
- Several possible applications including new therapeutics, cellular therapy and vaccination
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Quick-healing consumer care emulsion for poorly healing wounds
Quick-healing consumer care emulsion for poorly healing wounds
- Emulsion for poorly healing skin wounds and sunburn
- Accelerates healing & prevents wound infections with pathogens
- Strongly reduced skin transplant frequency in test hospital
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Sustainable one-pot preparation of versatile organo-phosphorus compounds
Sustainable one-pot preparation of versatile organo-phosphorus compounds
- Simple one-pot reaction using mild, non-corrosive conditions
- Reaction yields e.g. stannyl phosphines for direct reaction with electrophiles
- No separation/purification steps necessary
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TMEM16A inhibitors as a treatment option for cystic fibrosis
TMEM16A inhibitors as a treatment option for cystic fibrosis
- TMEM16A inhibitors represent a causal treatment for cystic fibrosis
- They reduce both excessive mucus formation and airway contraction
- Repurposing possible: TMEM16A inhibitors include FDA-approved and well-tolerated drugs
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TMEM16A inhibitors as a treatment option for polycystic kidney disease (PKD)
TMEM16A inhibitors as a treatment option for polycystic kidney disease (PKD)
- TMEM16A inhibitors represent a causative treatment for polycystic kidney disease
- Significant suppression of renal cysts
- Repurposing possible: TMEM16A inhibitors include FDA-approved and well-tolerated drugs
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Learning-based beamforming for acoustic and ultrasonic applications
Learning-based beamforming for acoustic and ultrasonic applications
- Ultrasound beamforming
- Deep learning
- High quality for real time imaging
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Designed Chemokine-Selective Peptides in the Fight Against Atherosclerosis and Inflammation
Designed Chemokine-Selective Peptides in the Fight Against Atherosclerosis and Inflammation
- Novel class of therapeutics for atherosclerotic plaques
- Soluble peptide-based mimics of the CXCR4 receptor
- High potency and target specificity
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Bioartificial Lymph Nodes
Bioartificial Lymph Nodes
- Lymphedema treatment
- Bioartificial lymph nodes
- Biodegradable material
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Virus-mimetic nanoparticles for diabetic nephropathy
Virus-mimetic nanoparticles for diabetic nephropathy
- Specific drug delivery via nanoparticles
- Virus like targeting in a two-stage process
- Dose reduction compared to free drug
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Novel approach for a non-invasive diagnosis of chronic rhinosinusitis with nasal polyps
Novel approach for a non-invasive diagnosis of chronic rhinosinusitis with nasal polyps
- Pappalysin-A is correlated with polyp growth in CRSwNP
- Non-invasive detection in nasal mucus by commercial kits
- Monitoring of disease-progression and response rate
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Innovative solid-liquid reactor for high-speed mass transfer & catalysis without clogging
Innovative solid-liquid reactor for high-speed mass transfer & catalysis without clogging
- Fully scalable rotating reactor for quick mass transfer reactions
- Broad variety of chemical- and pharmaceutical applications such as extraction & biocatalysis
- Especially effective for the use of small or deformable particles as solid reactant (no clogging)
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Shape matters – Innovative sealing cuff for endotracheal intubation
Shape matters – Innovative sealing cuff for endotracheal intubation
- Innovative sealing cuff prevents microaspiration
- Dynamically adapts to the surrounding structure and minimizes tissue damage
- Cost-effective production
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Reducing waste and time – Novel approach allows for rapid isotope production for medical diagnostics
Reducing waste and time – Novel approach allows for rapid isotope production for medical diagnostics
- ⁹⁹ᵐTc as one of the most important medical radioisotopes
- Novel dry-chemical separation of molybdenum and uranium
- More environmentally friendly production with less toxic waste
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When time is of the essence – Novel blood biomarker allows for a fast diagnosis of Type A aortic dissection
When time is of the essence – Novel blood biomarker allows for a fast diagnosis of Type A aortic dissection
- Type A aortic dissection is a medical emergency
- Novel protein biomarker for fast diagnosis
- Easy blood-based testing
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Innovative 3D cell culture matrix with tunable properties
Innovative 3D cell culture matrix with tunable properties
- New Matrix for 3D cell culture preparation
- Cost-effective material with defined material properties
- Allows free design of culture conditions
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Innovative braiding technique and bifurcation stents with a seamless transition area
Innovative braiding technique and bifurcation stents with a seamless transition area
- Optimized braiding technique for bifurcation stents
- Seamless transition area with a homogenous density for maximum stability and flexibility at bifurcation sites
- Secondary branches can be produced simultaneously
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Innovative 18F-labeled Norepinephrine analog PET tracers for broad diagnostic applications in neurology, cardiology and oncology
Innovative 18F-labeled Norepinephrine analog PET tracers for broad diagnostic applications in neurology, cardiology and oncology
- Simple and low-cost synthesis and superior labeling efficiency
- Extended tracer half-life and high PET signal strength
- Widely applicable in neurology, oncology and cardiology
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Tau aggregation inhibiting peptides as a basis for future therapies for tauopathies
Tau aggregation inhibiting peptides as a basis for future therapies for tauopathies
- Tau aggregation inhibiting peptides
- Strongly bind to tau monomers, -oligomers and -fibrils
- Suitable for future tauopathy therapies
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Heading in a new direction – Novel CARs specific for CD25 to treat chronic inflammatory processes
Heading in a new direction – Novel CARs specific for CD25 to treat chronic inflammatory processes
- Chimeric antigen receptors to target chronic inflammation
- Therapeutic effect independent of tissue type and source
- Applicable to any inflammatory process
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Better together – Novel dual-acting and disease-modifying approach to combat Alzheimer’s
Better together – Novel dual-acting and disease-modifying approach to combat Alzheimer’s
- Combinatory hybrid approach with disease-modifying properties
- Strong neuroprotection in in vivo Alzheimer’s model
- Absence of hepatotoxicity even at high doses
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Active emulgels for controlled zero-order drug release
Active emulgels for controlled zero-order drug release
- Platform for zero-order (linear) drug-release
- Constant, tunable release of hydrophobic drugs
- 3 components, economical and straightforward
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Realizing the benefits of gene silencing – Novel HDAC6 inhibitor for the treatment of inflammatory diseases
Realizing the benefits of gene silencing – Novel HDAC6 inhibitor for the treatment of inflammatory diseases
- Oral HDAC6 inhibitor with superior specificity
- Anti-inflammatory effect in in vivo arthritis model
- Alternative to first line anti-inflammatory drugs
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Novel heavy metal complexes as ex-vivo contrast agents for computed tomography scanning of biological samples
Novel heavy metal complexes as ex-vivo contrast agents for computed tomography scanning of biological samples
- Novel contrast agents for histological methods
- Drastic contrast enhancement for CT scanning
- Facilitation of highly detailed 3D information
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Efficacy boost for dendritic cell therapies
Efficacy boost for dendritic cell therapies
- Method to increase efficacy of existing DC-based cell therapies
- Enzymatic treatment improves T-cell priming capacity up to 10-fold
- Results in strong proliferation of tumor-killing T-cells
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Novel tool for the early diagnosis of sepsis
Novel tool for the early diagnosis of sepsis
- Diagnostic test for suspected sepsis (bacterial, viral incl. SARS-CoV, fungal)
- Easy and broadly applicable test, small blood sample volumes needed
- Allows much earlier diagnosis (~36h) than currently possible
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Highly promising AML treatment option targeting leukemic blasts and stem cells
Highly promising AML treatment option targeting leukemic blasts and stem cells
- Highly effective therapy for Acute Myeloid Leukemia (AML)
- Long-lasting elimination of leukemic blasts and leukemic stem cells
- Suitable for all major AML subgroups, low side effects
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Cutting cost and time - HCV immunoassay predicts clinical response rate to antiviral treatment
Cutting cost and time - HCV immunoassay predicts clinical response rate to antiviral treatment
- Antiviral drugs for HCV are effective but expensive
- Immunoassay can predict response to antiviral drugs
- Significant reduction of long-term treatment cost
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New tricks for an old system – Bacterial system enables site-specific ubiquitylation of proteins in living cells
New tricks for an old system – Bacterial system enables site-specific ubiquitylation of proteins in living cells
- Chemoenzymatic approach to study ubiquitylation
- Inducible attachment of ubiquitin marks to proteins
- Method to be applied to other protein modifications
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Method and System to Detect a Solute in a Solvent using Nuclear Magnetic Resonance
Method and System to Detect a Solute in a Solvent using Nuclear Magnetic Resonance
- MRI-based detection of non-toxic agents and approved X-ray contrast agents
- Simple interpretation of results due to less interference compared to CEST-type techniques
- Non-invasive measurement of pH-values or temperature
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Superior BChE inhibitors for Alzheimer’s Disease
Superior BChE inhibitors for Alzheimer’s Disease
- Highly potent BChE inhibitors
- BChE inhibitors with neuroprotectant properties
- Long and controllable duration of action
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GRAND-SLAM - The Method for quantification of new and old RNA
GRAND-SLAM - The Method for quantification of new and old RNA
- Labelling with SLAM-seq, TUC-seq or TLapse-seq
- Fully quantitative analyses of RNA (incl. single cell)
- Vertebrates, insects, plants & yeast, in vitro & in vivo
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Success Prediction of an Allergen- specific Immunotherapy
Success Prediction of an Allergen- specific Immunotherapy
- Innovative prediction method for the therapeutic success of an allergen-specific immunotherapy (AIT) at an early stage
- straightforward and easy determination of the relevant parameters from nasal sample material
- patient-friendly and economic
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Hydrogels: Injectable Depot-Systems
Hydrogels: Injectable Depot-Systems
- Gelatinize by a dual mechanism based on Diels-Alder reaction and physical crosslinking
- Stability and stiffness can be adjusted to therapeutic need
- Hydrogels are stable, in situ forming, non-toxic and particularly suitable for controlled drug release
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Immunotherapy for Chronic Liver Diseases
Immunotherapy for Chronic Liver Diseases
- Novel vaccination strategy against chronic liver diseases through stimulation of IMATEs with TLR9-L
- IMATEs are an anatomic compartment within the liver tissue consisting of myeloid cells
- iMATEs overcome regulatory cues that limit immune response during chronic liver infections
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Amyloid Inhibitory Peptides for Alzheimer’s Disease and Diabetes
Amyloid Inhibitory Peptides for Alzheimer’s Disease and Diabetes
- Macrocyclic peptides with drug-like properties
- Highly potent inhibitors of Aβ amyloid self-assembly
- Promising in vivo data from Alzheimer’s mouse model
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Protein Purification/Immobilization through negPeps
Protein Purification/Immobilization through negPeps
- NegPeps (magnetic particle binding peptides) are novel peptides with the potential to replace the common affinity tags based protein purification/immobilization
- NegPeps bind to magnetic nanoparticles in a reversible and controlled manner
- No specific surface functionalization necessary
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Rotating reactor for heterogeneous transfer of substances
Rotating reactor for heterogeneous transfer of substances
- Reactor for mass transfer reactions
- Biotech, food and beverage processing
- For small or deformable particles
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NF-κB-activated dendritic cells
NF-κB-activated dendritic cells
- that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
- DCs activation is mediated by via mRNA transfection
- Activated DCs lead to strong expansion of memory T cells and are much more stable than other DC vaccination products
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Urinary marker for bladder cancer detection
Urinary marker for bladder cancer detection
- The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
- LASP-1 overcomes the limitation of currently used cystoscopy and urine cytology for diagnosis of UCB
- LASP-1 is detected in voided urine sediment of bladder cancer patients and is combinable with a second marker to further raise specificity/sensitivity
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Needle assembly for relieving a pneumothorax
Needle assembly for relieving a pneumothorax
- Fast and easy to use medical device for relieving a Pneumothorax
- Enables safe patient transport
- Prevents serious inadvertent injuries
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Flexible and breathable nonwovens with superior electrical conductivity
Flexible and breathable nonwovens with superior electrical conductivity
- Bendable and breathable material with metal-like electrical conductivity
- Low silver content required, simple wet-laid process
- For e.g. lightweight electrodes and electric shielding
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Innovative ceramic fiber composite materials with high thermal and corrosion stabilities
Innovative ceramic fiber composite materials with high thermal and corrosion stabilities
- Superior ceramic fiber prepregs for high-temperature stable materials
- Prepregs storable without climate control, reversible drying process
- Little to no volume shrinkage during sintering
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Improving stability and secretion of antibodies
Improving stability and secretion of antibodies
- Improvement of the biophysical properties of antibodies and enhancement of antibody secretion by imitating the stabilizing structural elements of shark antibodies
- CL domain is modified by a conservative exchange of amino acids at two positions
- Compared to the wild type CL, the melting point of the modified CL domain is almost 10°C higher and its stability against urea-induced denaturation is also markedly increased
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Method for assessing the efficacy of immunmodulatory drugs
Method for assessing the efficacy of immunmodulatory drugs
- Biomarker using CD147/MCT1 destabilization as mechanism
- For the use of IMiDs (Immunomodulatory drugs)
- To treat hematologic malignancies like multiple myeloma (MM)
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Prognostic and predictive Biomarker for Melanoma
Prognostic and predictive Biomarker for Melanoma
- Prognostic test for patients with malignant melanoma
- Estimates patient life expectancy
- Biomarker for predicts melanoma therapy response
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New Catalyst System for High Performance Polymers
New Catalyst System for High Performance Polymers
- Superior method for the polymerization of Michael-type based monomers
- New versatile catalyst system
- Cheaper, fasterand greener process
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A calcium-sensor for NMR/MRI based diagnostic imaging using hyperpolarized xenon
A calcium-sensor for NMR/MRI based diagnostic imaging using hyperpolarized xenon
- in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
- in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
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PH-biosensor based on hyper- polarized zymonic acid for non-invasive imaging and spectroscopy
PH-biosensor based on hyper- polarized zymonic acid for non-invasive imaging and spectroscopy
- Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
- Potential for diagnosis and therapy of diseases characterized by aberrant acid-base balances
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Method and device for determining the presence of an analyte by means of small magnetic particles
Method and device for determining the presence of an analyte by means of small magnetic particles
- Cost Efficient Diagnostic
- Molecular Fingerprinting
- Blood Samples
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Cannula for ocular micro-injection
Cannula for ocular micro-injection
- Intra- and sub-retinal targeted administration of drugs
- Easy and highly precise targeting
- Treatment of Age-related Macular Degeneration (AMD)
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Small molecule inhibitors of cd40-traf6 interactions
Small molecule inhibitors of cd40-traf6 interactions
- New selective inhibitors for treatment of chronic inflammatory diseases, such as atherosclerosis, obesity and multiple sclerosis.
- Inhibitors selectively block CD40-TRAF6 interactions
- The selective blockage of the CD40-TRAF6 interactions strongly reduces inflammation, whereas unwanted immune-suppressive side effects are reduced
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