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• Surfactant-free Microemulsion Polymerization

  B79145

  Surfactant-free Microemulsion Polymerization

  • Basend on simple, low-cost, non-toxic substances. Very pure polymer particles can be obtainedby removing the hydrotrope.
  • Ideal for producers of polymer particles, e.g. for cosmetics, pharma, adhesives and paints
  • Avoid problems due to surfactant residues in the final product (e.g. foaming, harmful substances)
  • Possible access to hard-to-synthesizeco-polymers by tuning the monomer reactivity
• Germanium catalysts for hydrosilylations & siloxane couplings

  B81204

  Germanium catalysts for hydrosilylations & siloxane couplings

  • Highly efficient & selective cationic germanium catalysts. Precious metal-free (no discoloration issues)
  • Ideal for hydrosilylations and siloxane couplings, oxygen-free reaction settings possible
  • One-pot, cost-effective, and high-yield preparation of catalyst
• New catalysts for the production of superior PHB

  B82063

  New catalysts for the production of superior PHB

  • Biocompatible and biodegradable plastic with superior material properties compared to bacterial PHB
  • Cost-effective production via ring opening polymerization of ß‐butyrolactone
  • Thermomechanical properties similar to petrochemical PP, material suitable for melt processing
• Monitoring and puncturing system for percutaneous dilatational tracheostomy with improved puncture precision

  B81019

  Monitoring and puncturing system for percutaneous dilatational tracheostomy with improved puncture precision

  • Enables the physician to reliably identify the correct puncture site
  • Especially suited for patients with a challenging anatomy (e.g obese tissue, goiter, short neck,)
  • Minimizes the risk of severe or even fatal complications
• Advanced Radio-guided Surgery using Nanoparticles: Radiopharmaceutical for the Detection of Sentinel Lymph Nodes

  B82027

  Advanced Radio-guided Surgery using Nanoparticles: Radiopharmaceutical for the Detection of Sentinel Lymph Nodes

  • Radio-guided Surgery
  • Radiopharmaceutical
  • Nanotechnology
• Coating of catheter-based cardiac devices using TRPC6 Inhibitors for prevention of restenosis

  B79124

  Coating of catheter-based cardiac devices using TRPC6 Inhibitors for prevention of restenosis

  • Scar tissue as a central problem after stent implantation
  • Local coating of cardiac devices inhibits re-narrowing of vessel
  • Dual anti-proliferative and anti-migratory effect on cells
• The T-Cell-Therapy Success Code: Signatures of recent T-cell activation allow isolation of highly functional tumor-specific T cell receptors

  B81078

  The T-Cell-Therapy Success Code: Signatures of recent T-cell activation allow isolation of highly functional tumor-specific T cell receptors

  • Cost-effective isolation of highly functional tumor-specific TCRs
  • Method using predictive markers to identify TCRs of high functional quality
  • Isolation of TCRs from easily accessible peripheral blood
• PosH-Tag: Cost effective and highly speci- fic biomolecule separation with bare silica surfaces and immobilization using bare ma- gnetic iron-oxide nanoparticles

  B80037

  PosH-Tag: Cost effective and highly speci- fic biomolecule separation with bare silica surfaces and immobilization using bare ma- gnetic iron-oxide nanoparticles

  • Platform for protein purification and immobilization
  • Efficient and cost effective separation of target molecules
  • Without NTA modification and the use of imidazole
• SUPER NK cells cure metastatic cancer in mouse models

  B81137

  SUPER NK cells cure metastatic cancer in mouse models

  • Effective cure from advanced metastatic cancer in mouse models
  • Broadly applicable: metastasis from melanoma, colorectal and pancreatic cancer, etc.
  • Allogeneic setting allows off-the-shelf use
• Novel approach for surgical stabilization of disrupted pubic symphysis in pelvic injuries

  B80189

  Novel approach for surgical stabilization of disrupted pubic symphysis in pelvic injuries

  • Trauma accidents often result in life threatening pelvic injuries
  • 2 component cable-clamp implant for disrupted pubic symphysis
  • Fewer complications compared to conventional approach
• Anti-PSMA antibodies for therapeutic and diagnostic purposes

  B80048

  Anti-PSMA antibodies for therapeutic and diagnostic purposes

  • Anti-PSMA antibody with sub-nanomolar affinity high specificity for native PSMA and good thermal stability
  • Pre-clinical optimization for developability
  • Among others, suitable for antibody-drug-conjugates, photodynamic therapy or imaging
• Implant and implant applicator for endoscopic and customizable anastomosis

  B80080

  Implant and implant applicator for endoscopic and customizable anastomosis

  • System for endoluminal anastomosis
  • Adjustable to the lumen size of the patient’s intestine
  • Force application mechanism at flexible endoscope tip for arbitrary shapes
• MPS – rapid binding test device

  B81189

  MPS – rapid binding test device

  • Fast and highly sensitive evaluation of data
  • Measurement results in milliseconds with sub-femto molar sensitivity
  • Portable, simple, robust, flexible & cost-effective
• System and method for generating a traveling field free line

  B77202

  System and method for generating a traveling field free line

  • MPI Scanning of 2D & 3D volumes without specimen displacement
  • Large field of view and accurate scanning times for MPI applications
  • Novel encoding concept enables rapid 3D imaging
• System for the one-sided generation of magnetic fields for the multidimensional encoding of magnetic particles and method of operation thereof

  B78164

  System for the one-sided generation of magnetic fields for the multidimensional encoding of magnetic particles and method of operation thereof

  • Magnetic particle imaging for measuring large and small sample volumes
  • Low magnetic field strenghts suitable for clinical applications
  • Novel encoding concept enables rapid 3D imaging
• Direct Extraction of Astaxanthin from H. pluvialis

  B78052

  Direct Extraction of Astaxanthin from H. pluvialis

  • Novel downstream process for natural astaxanthin extraction
  • Lower investment costs compared to conventional industrial process
  • Opportunity to serve increased consumer demand
• Controlled release of therapeutical agents from polymer brush coatings by employing reversible polymer condensation using ionic cross-linkers

  B79086

  Controlled release of therapeutical agents from polymer brush coatings by employing reversible polymer condensation using ionic cross-linkers

  • Surface coat with drug encapsulation for medical implants
  • Triggered drug release by contact with physiological salt concentrations
  • Quickly achieve therapeutic levels at actual site of inflammation
• Drug repurposing: Beta-lactam antibiotic with high efficacy against colorectal cancer

  B80177

  Drug repurposing: Beta-lactam antibiotic with high efficacy against colorectal cancer

  • Re-purposing: beta-lactam antibiotic for cancer treatment
  • Promising animal data for colorectal cancer in various stages, ongoing research for additional solid cancers
  • E.g. for combination with existing cancer therapies, very low side effects
• Nanoparticles for the targeted treatment of neovascular ocular diseases

  B79130

  Nanoparticles for the targeted treatment of neovascular ocular diseases

  • systemic therapy instead of intravitreal antibody injections
  • a single systemic injection cured retinopathy of prematurity in mouse model
  • causal treatment of all neovascular ocular diseases
• Lab on a Chip for rapid testing applications

  B79091

  Lab on a Chip for rapid testing applications

  • Rapid detection of bio-chemical substances in fluids
  • Easy and fast – requires only small amount of testfluid
  • No sample preparation needed
• Natural Antioxidants for food or cosmetic oils and fats

  B78099 | B79090

  Natural Antioxidants for food or cosmetic oils and fats

  • Highly effective, edible natural antioxidants for oils and fats
  • Antioxidant and antibacterial effects for long shelf life
  • For edible oils and fats, cosmetics and other oil-based products
• Liposome-encapsidated bioactive hexapeptides for targeted pancreatic cancer therap

  B80078

  Liposome-encapsidated bioactive hexapeptides for targeted pancreatic cancer therap

  • Targeted tumor therapy for highly aggressive pancreatic cancers
  • Particularly suited for combinational therapy
  • Targeted therapies for human solid tumors bearing wild-type TP53
• Quick-healing consumer care emulsion for poorly healing wounds

  X19014

  Quick-healing consumer care emulsion for poorly healing wounds

  • Emulsion for poorly healing skin wounds and sunburn
  • Accelerates healing & prevents wound infections with pathogens
  • Strongly reduced skin transplant frequency in test hospital
• Sustainable one-pot preparation of versatile organo-phosphorus compounds

  B79039

  Sustainable one-pot preparation of versatile organo-phosphorus compounds

  • Simple one-pot reaction using mild, non-corrosive conditions
  • Reaction yields e.g. stannyl phosphines for direct reaction with electrophiles
  • No separation/purification steps necessary
• TMEM16A inhibitors as a treatment option for cystic fibrosis

  B78025

  TMEM16A inhibitors as a treatment option for cystic fibrosis

  • TMEM16A inhibitors represent a causal treatment for cystic fibrosis
  • They reduce both excessive mucus formation and airway contraction
  • Repurposing possible: TMEM16A inhibitors include FDA-approved and well-tolerated drugs
• Learning-based beamforming for acoustic and ultrasonic applications

  B77199

  Learning-based beamforming for acoustic and ultrasonic applications

  • Ultrasound beamforming
  • Deep learning
  • High quality for real time imaging
• Designed Chemokine-Selective Peptides in the Fight Against Atherosclerosis and Inflammation

  B80034

  Designed Chemokine-Selective Peptides in the Fight Against Atherosclerosis and Inflammation

  • Novel class of therapeutics for atherosclerotic plaques
  • Soluble peptide-based mimics of the CXCR4 receptor
  • High potency and target specificity
• Virus-mimetic nanoparticles for diabetic nephropathy

  B79122

  Virus-mimetic nanoparticles for diabetic nephropathy

  • Specific drug delivery via nanoparticles
  • Virus like targeting in a two-stage process
  • Dose reduction compared to free drug
• Novel approach for a non-invasive diagnosis of chronic rhinosinusitis with nasal polyps

  B78106

  Novel approach for a non-invasive diagnosis of chronic rhinosinusitis with nasal polyps

  • Pappalysin-A is correlated with polyp growth in CRSwNP
  • Non-invasive detection in nasal mucus by commercial kits
  • Monitoring of disease-progression and response rate
• Innovative solid-liquid reactor for high-speed mass transfer & catalysis without clogging

  B78159

  Innovative solid-liquid reactor for high-speed mass transfer & catalysis without clogging

  • Fully scalable rotating reactor for quick mass transfer reactions
  • Broad variety of chemical- and pharmaceutical applications such as extraction & biocatalysis
  • Especially effective for the use of small or deformable particles as solid reactant (no clogging)
• Reducing waste and time – Novel approach allows for rapid isotope production for medical diagnostics

  B78139

  Reducing waste and time – Novel approach allows for rapid isotope production for medical diagnostics

  • ⁹⁹ᵐTc as one of the most important medical radioisotopes
  • Novel dry-chemical separation of molybdenum and uranium
  • More environmentally friendly production with less toxic waste
• When time is of the essence – Novel blood biomarker allows for a fast diagnosis of Type A aortic dissection

  X19012

  When time is of the essence – Novel blood biomarker allows for a fast diagnosis of Type A aortic dissection

  • Type A aortic dissection is a medical emergency
  • Novel protein biomarker for fast diagnosis
  • Easy blood-based testing
• Innovative 3D cell culture matrix with tunable properties

  B79074

  Innovative 3D cell culture matrix with tunable properties

  • New Matrix for 3D cell culture preparation
  • Cost-effective material with defined material properties
  • Allows free design of culture conditions
• Innovative braiding technique and bifurcation stents with a seamless transition area

  B78126

  Innovative braiding technique and bifurcation stents with a seamless transition area

  • Optimized braiding technique for bifurcation stents
  • Seamless transition area with a homogenous density for maximum stability and flexibility at bifurcation sites
  • Secondary branches can be produced simultaneously
• Innovative 18F-labeled Norepinephrine analog PET tracers for broad diagnostic applications in neurology, cardiology and oncology

  B78129

  Innovative 18F-labeled Norepinephrine analog PET tracers for broad diagnostic applications in neurology, cardiology and oncology

  • Simple and low-cost synthesis and superior labeling efficiency
  • Extended tracer half-life and high PET signal strength
  • Widely applicable in neurology, oncology and cardiology
• Tau aggregation inhibiting peptides as a basis for future therapies for tauopathies

  B79054

  Tau aggregation inhibiting peptides as a basis for future therapies for tauopathies

  • Tau aggregation inhibiting peptides
  • Strongly bind to tau monomers, -oligomers and -fibrils
  • Suitable for future tauopathy therapies
• Heading in a new direction – Novel CARs specific for CD25 to treat chronic inflammatory processes

  B79055

  Heading in a new direction – Novel CARs specific for CD25 to treat chronic inflammatory processes

  • Chimeric antigen receptors to target chronic inflammation
  • Therapeutic effect independent of tissue type and source
  • Applicable to any inflammatory process
• Better together – Novel dual-acting and disease-modifying approach to combat Alzheimer’s

  B79080

  Better together – Novel dual-acting and disease-modifying approach to combat Alzheimer’s

  • Combinatory hybrid approach with disease-modifying properties
  • Strong neuroprotection in in vivo Alzheimer’s model
  • Absence of hepatotoxicity even at high doses
• Realizing the benefits of gene silencing – Novel HDAC6 inhibitor for the treatment of inflammatory diseases

  B73271 | B77007

  Realizing the benefits of gene silencing – Novel HDAC6 inhibitor for the treatment of inflammatory diseases

  • Oral HDAC6 inhibitor with superior specificity
  • Anti-inflammatory effect in in vivo arthritis model
  • Alternative to first line anti-inflammatory drugs
• Novel heavy metal complexes as ex-vivo contrast agents for computed tomography scanning of biological samples

  B76184 / B76179

  Novel heavy metal complexes as ex-vivo contrast agents for computed tomography scanning of biological samples

  • Novel contrast agents for histological methods
  • Drastic contrast enhancement for CT scanning
  • Facilitation of highly detailed 3D information
• Efficacy boost for dendritic cell therapies

  B73083

  Efficacy boost for dendritic cell therapies

  • Method to increase efficacy of existing DC-based cell therapies
  • Enzymatic treatment improves T-cell priming capacity up to 10-fold
  • Results in strong proliferation of tumor-killing T-cells
• Novel tool for the early diagnosis of sepsis

  B79000

  Novel tool for the early diagnosis of sepsis

  • Diagnostic test for suspected sepsis (bacterial, viral incl. SARS-CoV, fungal)
  • Easy and broadly applicable test, small blood sample volumes needed
  • Allows much earlier diagnosis (~36h) than currently possible
• Highly promising AML treatment option targeting leukemic blasts and stem cells

  B78209

  Highly promising AML treatment option targeting leukemic blasts and stem cells

  • Highly effective therapy for Acute Myeloid Leukemia (AML)
  • Long-lasting elimination of leukemic blasts and leukemic stem cells
  • Suitable for all major AML subgroups, low side effects
• Cutting cost and time - HCV immunoassay predicts clinical response rate to antiviral treatment

  B76124

  Cutting cost and time - HCV immunoassay predicts clinical response rate to antiviral treatment

  • Antiviral drugs for HCV are effective but expensive
  • Immunoassay can predict response to antiviral drugs
  • Significant reduction of long-term treatment cost
• New tricks for an old system – Bacterial system enables site-specific ubiquitylation of proteins in living cells

  B78098

  New tricks for an old system – Bacterial system enables site-specific ubiquitylation of proteins in living cells

  • Chemoenzymatic approach to study ubiquitylation
  • Inducible attachment of ubiquitin marks to proteins
  • Method to be applied to other protein modifications
• Method and System to Detect a Solute in a Solvent using Nuclear Magnetic Resonance

  B77091

  Method and System to Detect a Solute in a Solvent using Nuclear Magnetic Resonance

  • MRI-based detection of non-toxic agents and approved X-ray contrast agents
  • Simple interpretation of results due to less interference compared to CEST-type techniques
  • Non-invasive measurement of pH-values or temperature
• Success Prediction of an Allergen- specific Immunotherapy

  B76137

  Success Prediction of an Allergen- specific Immunotherapy

  • Innovative prediction method for the therapeutic success of an allergen-specific immunotherapy (AIT) at an early stage
  • straightforward and easy determination of the relevant parameters from nasal sample material
  • patient-friendly and economic
• Amyloid Inhibitory Peptides for Alzheimer’s Disease and Diabetes

  B78094

  Amyloid Inhibitory Peptides for Alzheimer’s Disease and Diabetes

  • Macrocyclic peptides with drug-like properties
  • Highly potent inhibitors of Aβ amyloid self-assembly
  • Promising in vivo data from Alzheimer’s mouse model
• Protein Purification/Immobilization through negPeps

  B76080

  Protein Purification/Immobilization through negPeps

  • NegPeps (magnetic particle binding peptides) are novel peptides with the potential to replace the common affinity tags based protein purification/immobilization
  • NegPeps bind to magnetic nanoparticles in a reversible and controlled manner
  • No specific surface functionalization necessary
• Rotating reactor for heterogeneous ­transfer of substances

  B78159

  Rotating reactor for heterogeneous ­transfer of substances

  • Reactor for mass transfer reactions
  • Biotech, food and beverage processing
  • For small or deformable particles
• NF-κB-activated dendritic cells

  B71259

  NF-κB-activated dendritic cells

  • that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
  • DCs activation is mediated by via mRNA transfection
  • Activated DCs lead to strong expansion of memory T cells and are much more stable than other DC vaccination products
• Needle assembly for relieving a pneumothorax

  B77122

  Needle assembly for relieving a pneumothorax

  • Fast and easy to use medical device for relieving a Pneumothorax
  • Enables safe patient transport
  • Prevents serious inadvertent injuries
• Flexible and breathable nonwovens with superior electrical conductivity

  B76140

  Flexible and breathable nonwovens with superior electrical conductivity

  • Bendable and breathable material with metal-like electrical conductivity
  • Low silver content required, simple wet-laid process
  • For e.g. lightweight electrodes and electric shielding
• Innovative ceramic fiber composite materials with high thermal and corrosion stabilities

  B74087, B76032

  Innovative ceramic fiber composite materials with high thermal and corrosion stabilities

  • Superior ceramic fiber prepregs for high-temperature stable materials
  • Prepregs storable without climate control, reversible drying process
  • Little to no volume shrinkage during sintering
• Improving stability and secretion of ­antibodies

  B73076

  Improving stability and secretion of ­antibodies

  • Improvement of the biophysical properties of antibodies and enhancement of antibody secretion by imitating the stabilizing structural elements of shark antibodies
  • CL domain is modified by a conservative exchange of amino acids at two positions
  • Compared to the wild type CL, the melting point of the modified CL domain is almost 10°C higher and its stability against urea-induced denaturation is also markedly increased
• Method for assessing the efficacy of immunmodulatory drugs

  B74042

  Method for assessing the efficacy of immunmodulatory drugs

  • Biomarker using CD147/MCT1 destabilization as mechanism
  • For the use of IMiDs (Immunomodulatory drugs)
  • To treat hematologic malignancies like multiple myeloma (MM)
• Prognostic and predictive Biomarker for Melanoma

  B78091

  Prognostic and predictive Biomarker for Melanoma

  • Prognostic test for patients with malignant melanoma
  • Estimates patient life expectancy
  • Biomarker for predicts melanoma therapy response
• New Catalyst System for High ­Performance Polymers

  B75246 | B74151 | B76002 | B76107 | B76177

  New Catalyst System for High ­Performance Polymers

  • Superior method for the polymerization of Michael-type based monomers
  • New versatile catalyst system
  • Cheaper, fasterand greener process
• A calcium-sensor for NMR/MRI based diagnostic imaging using hyperpolarized xenon

  B75123

  A calcium-sensor for NMR/MRI based diagnostic imaging using hyperpolarized xenon

  • in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
  • in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
• PH-biosensor based on hyper- polarized zymonic acid for non-invasive imaging and spectroscopy

  B73167

  PH-biosensor based on hyper- polarized zymonic acid for non-invasive imaging and spectroscopy

  • Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
  • Potential for diagnosis and therapy of diseases characterized by aberrant acid-base balances
• Method and device for determining the presence of an analyte by means of small magnetic particles

  B71191

  Method and device for determining the presence of an analyte by means of small magnetic particles

  • Cost Efficient Diagnostic
  • Molecular Fingerprinting
  • Blood Samples
• Cannula for ocular micro-injection

  B75028

  Cannula for ocular micro-injection

  • ‍Intra- and sub-retinal targeted administration of drugs
  • Easy and highly precise targeting
  • Treatment of Age-related Macular Degeneration (AMD)

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