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• Drug repurposing: Beta-lactam antibiotic with high efficacy against colorectal cancer

  B80177

  Drug repurposing: Beta-lactam antibiotic with high efficacy against colorectal cancer

  • Re-purposing: beta-lactam antibiotic for cancer treatment
  • Promising animal data for colorectal cancer in various stages, ongoing research for additional solid cancers
  • E.g. for combination with existing cancer therapies, very low side effects
• Nanoparticles for the targeted treatment of neovascular ocular diseases

  B79130

  Nanoparticles for the targeted treatment of neovascular ocular diseases

  • systemic therapy instead of intravitreal antibody injections
  • a single systemic injection cured retinopathy of prematurity in mouse model
  • causal treatment of all neovascular ocular diseases
• Lab on a Chip for rapid testing applications

  B79091

  Lab on a Chip for rapid testing applications

  • Rapid detection of bio-chemical substances in fluids
  • Easy and fast – requires only small amount of testfluid
  • No sample preparation needed
• Natural Antioxidants for food or cosmetic oils and fats

  B78099 | B79090

  Natural Antioxidants for food or cosmetic oils and fats

  • Highly effective, edible natural antioxidants for oils and fats
  • Antioxidant and antibacterial effects for long shelf life
  • For edible oils and fats, cosmetics and other oil-based products
• Liposome-encapsidated bioactive hexapeptides for targeted pancreatic cancer therap

  B80078

  Liposome-encapsidated bioactive hexapeptides for targeted pancreatic cancer therap

  • Targeted tumor therapy for highly aggressive pancreatic cancers
  • Particularly suited for combinational therapy
  • Targeted therapies for human solid tumors bearing wild-type TP53
• Influenza-specific T-cell receptor (TCR)

  B73117

  Influenza-specific T-cell receptor (TCR)

  • Influenza specific TCR
  • Highly conserved epitope
  • Several possible applications including new therapeutics, cellular therapy and vaccination
• Quick-healing consumer care emulsion for poorly healing wounds

  X19014

  Quick-healing consumer care emulsion for poorly healing wounds

  • Emulsion for poorly healing skin wounds and sunburn
  • Accelerates healing & prevents wound infections with pathogens
  • Strongly reduced skin transplant frequency in test hospital
• Sustainable one-pot preparation of versatile organo-phosphorus compounds

  B79039

  Sustainable one-pot preparation of versatile organo-phosphorus compounds

  • Simple one-pot reaction using mild, non-corrosive conditions
  • Reaction yields e.g. stannyl phosphines for direct reaction with electrophiles
  • No separation/purification steps necessary
• TMEM16A inhibitors as a treatment option for cystic fibrosis

  B78025

  TMEM16A inhibitors as a treatment option for cystic fibrosis

  • TMEM16A inhibitors represent a causal treatment for cystic fibrosis
  • They reduce both excessive mucus formation and airway contraction
  • Repurposing possible: TMEM16A inhibitors include FDA-approved and well-tolerated drugs
• TMEM16A inhibitors as a treatment option for polycystic kidney disease (PKD)

  B79076

  TMEM16A inhibitors as a treatment option for polycystic kidney disease (PKD)

  • TMEM16A inhibitors represent a causative treatment for polycystic kidney disease
  • Significant suppression of renal cysts
  • Repurposing possible: TMEM16A inhibitors include FDA-approved and well-tolerated drugs
• Learning-based beamforming for acoustic and ultrasonic applications

  B77199

  Learning-based beamforming for acoustic and ultrasonic applications

  • Ultrasound beamforming
  • Deep learning
  • High quality for real time imaging
• Designed Chemokine-Selective Peptides in the Fight Against Atherosclerosis and Inflammation

  B80034

  Designed Chemokine-Selective Peptides in the Fight Against Atherosclerosis and Inflammation

  • Novel class of therapeutics for atherosclerotic plaques
  • Soluble peptide-based mimics of the CXCR4 receptor
  • High potency and target specificity
• Bioartificial Lymph Nodes

  B74182

  Bioartificial Lymph Nodes

  • Lymphedema treatment
  • Bioartificial lymph nodes
  • Biodegradable material
• Virus-mimetic nanoparticles for diabetic nephropathy

  B79122

  Virus-mimetic nanoparticles for diabetic nephropathy

  • Specific drug delivery via nanoparticles
  • Virus like targeting in a two-stage process
  • Dose reduction compared to free drug
• Novel approach for a non-invasive diagnosis of chronic rhinosinusitis with nasal polyps

  B78106

  Novel approach for a non-invasive diagnosis of chronic rhinosinusitis with nasal polyps

  • Pappalysin-A is correlated with polyp growth in CRSwNP
  • Non-invasive detection in nasal mucus by commercial kits
  • Monitoring of disease-progression and response rate
• Innovative solid-liquid reactor for high-speed mass transfer & catalysis without clogging

  B78159

  Innovative solid-liquid reactor for high-speed mass transfer & catalysis without clogging

  • Fully scalable rotating reactor for quick mass transfer reactions
  • Broad variety of chemical- and pharmaceutical applications such as extraction & biocatalysis
  • Especially effective for the use of small or deformable particles as solid reactant (no clogging)
• Shape matters – Innovative sealing cuff for endotracheal intubation

  B79159

  Shape matters – Innovative sealing cuff for endotracheal intubation

  • Innovative sealing cuff prevents microaspiration
  • Dynamically adapts to the surrounding structure and minimizes tissue damage
  • Cost-effective production
• Reducing waste and time – Novel approach allows for rapid isotope production for medical diagnostics

  B78139

  Reducing waste and time – Novel approach allows for rapid isotope production for medical diagnostics

  • ⁹⁹ᵐTc as one of the most important medical radioisotopes
  • Novel dry-chemical separation of molybdenum and uranium
  • More environmentally friendly production with less toxic waste
• When time is of the essence – Novel blood biomarker allows for a fast diagnosis of Type A aortic dissection

  X19012

  When time is of the essence – Novel blood biomarker allows for a fast diagnosis of Type A aortic dissection

  • Type A aortic dissection is a medical emergency
  • Novel protein biomarker for fast diagnosis
  • Easy blood-based testing
• Innovative 3D cell culture matrix with tunable properties

  B79074

  Innovative 3D cell culture matrix with tunable properties

  • New Matrix for 3D cell culture preparation
  • Cost-effective material with defined material properties
  • Allows free design of culture conditions
• Innovative braiding technique and bifurcation stents with a seamless transition area

  B78126

  Innovative braiding technique and bifurcation stents with a seamless transition area

  • Optimized braiding technique for bifurcation stents
  • Seamless transition area with a homogenous density for maximum stability and flexibility at bifurcation sites
  • Secondary branches can be produced simultaneously
• Innovative 18F-labeled Norepinephrine analog PET tracers for broad diagnostic applications in neurology, cardiology and oncology

  B78129

  Innovative 18F-labeled Norepinephrine analog PET tracers for broad diagnostic applications in neurology, cardiology and oncology

  • Simple and low-cost synthesis and superior labeling efficiency
  • Extended tracer half-life and high PET signal strength
  • Widely applicable in neurology, oncology and cardiology
• Tau aggregation inhibiting peptides as a basis for future therapies for tauopathies

  B79054

  Tau aggregation inhibiting peptides as a basis for future therapies for tauopathies

  • Tau aggregation inhibiting peptides
  • Strongly bind to tau monomers, -oligomers and -fibrils
  • Suitable for future tauopathy therapies
• Heading in a new direction – Novel CARs specific for CD25 to treat chronic inflammatory processes

  B79055

  Heading in a new direction – Novel CARs specific for CD25 to treat chronic inflammatory processes

  • Chimeric antigen receptors to target chronic inflammation
  • Therapeutic effect independent of tissue type and source
  • Applicable to any inflammatory process
• Better together – Novel dual-acting and disease-modifying approach to combat Alzheimer’s

  B79080

  Better together – Novel dual-acting and disease-modifying approach to combat Alzheimer’s

  • Combinatory hybrid approach with disease-modifying properties
  • Strong neuroprotection in in vivo Alzheimer’s model
  • Absence of hepatotoxicity even at high doses
• Active emulgels for controlled zero-order drug release

  B79089

  Active emulgels for controlled zero-order drug release

  • Platform for zero-order (linear) drug-release
  • Constant, tunable release of hydrophobic drugs
  • 3 components, economical and straightforward
• Realizing the benefits of gene silencing – Novel HDAC6 inhibitor for the treatment of inflammatory diseases

  B73271 | B77007

  Realizing the benefits of gene silencing – Novel HDAC6 inhibitor for the treatment of inflammatory diseases

  • Oral HDAC6 inhibitor with superior specificity
  • Anti-inflammatory effect in in vivo arthritis model
  • Alternative to first line anti-inflammatory drugs
• Novel heavy metal complexes as ex-vivo contrast agents for computed tomography scanning of biological samples

  B76184 / B76179

  Novel heavy metal complexes as ex-vivo contrast agents for computed tomography scanning of biological samples

  • Novel contrast agents for histological methods
  • Drastic contrast enhancement for CT scanning
  • Facilitation of highly detailed 3D information
• Efficacy boost for dendritic cell therapies

  B73083

  Efficacy boost for dendritic cell therapies

  • Method to increase efficacy of existing DC-based cell therapies
  • Enzymatic treatment improves T-cell priming capacity up to 10-fold
  • Results in strong proliferation of tumor-killing T-cells
• Novel tool for the early diagnosis of sepsis

  B79000

  Novel tool for the early diagnosis of sepsis

  • Diagnostic test for suspected sepsis (bacterial, viral incl. SARS-CoV, fungal)
  • Easy and broadly applicable test, small blood sample volumes needed
  • Allows much earlier diagnosis (~36h) than currently possible
• Highly promising AML treatment option targeting leukemic blasts and stem cells

  B78209

  Highly promising AML treatment option targeting leukemic blasts and stem cells

  • Highly effective therapy for Acute Myeloid Leukemia (AML)
  • Long-lasting elimination of leukemic blasts and leukemic stem cells
  • Suitable for all major AML subgroups, low side effects
• Cutting cost and time - HCV immunoassay predicts clinical response rate to antiviral treatment

  B76124

  Cutting cost and time - HCV immunoassay predicts clinical response rate to antiviral treatment

  • Antiviral drugs for HCV are effective but expensive
  • Immunoassay can predict response to antiviral drugs
  • Significant reduction of long-term treatment cost
• New tricks for an old system – Bacterial system enables site-specific ubiquitylation of proteins in living cells

  B78098

  New tricks for an old system – Bacterial system enables site-specific ubiquitylation of proteins in living cells

  • Chemoenzymatic approach to study ubiquitylation
  • Inducible attachment of ubiquitin marks to proteins
  • Method to be applied to other protein modifications
• Method and System to Detect a Solute in a Solvent using Nuclear Magnetic Resonance

  B77091

  Method and System to Detect a Solute in a Solvent using Nuclear Magnetic Resonance

  • MRI-based detection of non-toxic agents and approved X-ray contrast agents
  • Simple interpretation of results due to less interference compared to CEST-type techniques
  • Non-invasive measurement of pH-values or temperature
• Superior BChE inhibitors for Alzheimer’s Disease

  B78084

  Superior BChE inhibitors for Alzheimer’s Disease

  • Highly potent BChE inhibitors
  • BChE inhibitors with neuroprotectant properties
  • Long and controllable duration of action
• GRAND-SLAM - The Method for quantification of new and old RNA

  B78083

  GRAND-SLAM - The Method for quantification of new and old RNA

  • Labelling with SLAM-seq, TUC-seq or TLapse-seq
  • Fully quantitative analyses of RNA (incl. single cell)
  • Vertebrates, insects, plants & yeast, in vitro & in vivo
• Success Prediction of an Allergen- specific Immunotherapy

  B76137

  Success Prediction of an Allergen- specific Immunotherapy

  • Innovative prediction method for the therapeutic success of an allergen-specific immunotherapy (AIT) at an early stage
  • straightforward and easy determination of the relevant parameters from nasal sample material
  • patient-friendly and economic
• Hydrogels: Injectable Depot-Systems

  B76151

  Hydrogels: Injectable Depot-Systems

  • Gelatinize by a dual mechanism based on Diels-Alder reaction and physical crosslinking
  • Stability and stiffness can be adjusted to therapeutic need
  • Hydrogels are stable, in situ forming, non-toxic and particularly suitable for controlled drug release
• Process for isolation of odoriferous agents

  B75122

  Process for isolation of odoriferous agents

  • Fast low-temperature extraction of natural fragrances
  • Mild, non-toxic and effective
  • Water based green process
• Immunotherapy for Chronic Liver Diseases

  B72272

  Immunotherapy for Chronic Liver Diseases

  • Novel vaccination strategy against chronic liver diseases through stimulation of IMATEs with TLR9-L
  • IMATEs are an anatomic compartment within the liver tissue consisting of myeloid cells
  • iMATEs overcome regulatory cues that limit immune response during chronic liver infections
• Amyloid Inhibitory Peptides for Alzheimer’s Disease and Diabetes

  B78094

  Amyloid Inhibitory Peptides for Alzheimer’s Disease and Diabetes

  • Macrocyclic peptides with drug-like properties
  • Highly potent inhibitors of Aβ amyloid self-assembly
  • Promising in vivo data from Alzheimer’s mouse model
• Protein Purification/Immobilization through negPeps

  B76080

  Protein Purification/Immobilization through negPeps

  • NegPeps (magnetic particle binding peptides) are novel peptides with the potential to replace the common affinity tags based protein purification/immobilization
  • NegPeps bind to magnetic nanoparticles in a reversible and controlled manner
  • No specific surface functionalization necessary
• Rotating reactor for heterogeneous ­transfer of substances

  B78159

  Rotating reactor for heterogeneous ­transfer of substances

  • Reactor for mass transfer reactions
  • Biotech, food and beverage processing
  • For small or deformable particles
• NF-κB-activated dendritic cells

  B71259

  NF-κB-activated dendritic cells

  • that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
  • DCs activation is mediated by via mRNA transfection
  • Activated DCs lead to strong expansion of memory T cells and are much more stable than other DC vaccination products
• Urinary marker for bladder cancer detection

  B71211

  Urinary marker for bladder cancer detection

  • The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
  • LASP-1 overcomes the limitation of currently used cystoscopy and urine cytology for diagnosis of UCB
  • LASP-1 is detected in voided urine sediment of bladder cancer patients and is combinable with a second marker to further raise specificity/sensitivity
• Needle assembly for relieving a pneumothorax

  B77122

  Needle assembly for relieving a pneumothorax

  • Fast and easy to use medical device for relieving a Pneumothorax
  • Enables safe patient transport
  • Prevents serious inadvertent injuries
• Flexible and breathable nonwovens with superior electrical conductivity

  B76140

  Flexible and breathable nonwovens with superior electrical conductivity

  • Bendable and breathable material with metal-like electrical conductivity
  • Low silver content required, simple wet-laid process
  • For e.g. lightweight electrodes and electric shielding
• Innovative ceramic fiber composite materials with high thermal and corrosion stabilities

  B74087, B76032

  Innovative ceramic fiber composite materials with high thermal and corrosion stabilities

  • Superior ceramic fiber prepregs for high-temperature stable materials
  • Prepregs storable without climate control, reversible drying process
  • Little to no volume shrinkage during sintering
• Improving stability and secretion of ­antibodies

  B73076

  Improving stability and secretion of ­antibodies

  • Improvement of the biophysical properties of antibodies and enhancement of antibody secretion by imitating the stabilizing structural elements of shark antibodies
  • CL domain is modified by a conservative exchange of amino acids at two positions
  • Compared to the wild type CL, the melting point of the modified CL domain is almost 10°C higher and its stability against urea-induced denaturation is also markedly increased
• Method for assessing the efficacy of immunmodulatory drugs

  B74042

  Method for assessing the efficacy of immunmodulatory drugs

  • Biomarker using CD147/MCT1 destabilization as mechanism
  • For the use of IMiDs (Immunomodulatory drugs)
  • To treat hematologic malignancies like multiple myeloma (MM)
• Prognostic and predictive Biomarker for Melanoma

  B78091

  Prognostic and predictive Biomarker for Melanoma

  • Prognostic test for patients with malignant melanoma
  • Estimates patient life expectancy
  • Biomarker for predicts melanoma therapy response
• New Catalyst System for High ­Performance Polymers

  B75246 | B74151 | B76002 | B76107 | B76177

  New Catalyst System for High ­Performance Polymers

  • Superior method for the polymerization of Michael-type based monomers
  • New versatile catalyst system
  • Cheaper, fasterand greener process
• A calcium-sensor for NMR/MRI based diagnostic imaging using hyperpolarized xenon

  B75123

  A calcium-sensor for NMR/MRI based diagnostic imaging using hyperpolarized xenon

  • in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
  • in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
• PH-biosensor based on hyper- polarized zymonic acid for non-invasive imaging and spectroscopy

  B73167

  PH-biosensor based on hyper- polarized zymonic acid for non-invasive imaging and spectroscopy

  • Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
  • Potential for diagnosis and therapy of diseases characterized by aberrant acid-base balances
• A convertible multi-purpose bioreactor

  B76089

  A convertible multi-purpose bioreactor

  • Convertible multi-purpose bioreactor provides 4in1 combination of different types of bioreactosr:
  • stirred-tank bioreactor
  • gas-lift bioreactor
  • packed-bed biofilm reactor
  • trickling filter biofilm reactor
• Method and device for determining the presence of an analyte by means of small magnetic particles

  B71191

  Method and device for determining the presence of an analyte by means of small magnetic particles

  • Cost Efficient Diagnostic
  • Molecular Fingerprinting
  • Blood Samples
• Cannula for ocular micro-injection

  B75028

  Cannula for ocular micro-injection

  • ‍Intra- and sub-retinal targeted administration of drugs
  • Easy and highly precise targeting
  • Treatment of Age-related Macular Degeneration (AMD)
• Small molecule inhibitors of cd40-traf6 ­interactions

  B72031

  Small molecule inhibitors of cd40-traf6 ­interactions

  • New selective inhibitors for treatment of chronic inflammatory diseases, such as atherosclerosis, obesity and multiple sclerosis.
  • Inhibitors selectively block CD40-TRAF6 interactions
  • The selective blockage of the CD40-TRAF6 interactions strongly reduces inflammation, whereas unwanted immune-suppressive side effects are reduced

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