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• Cytosolic RNA depletion by polymeric nanoparticles

  B83117

  Cytosolic RNA depletion by polymeric nanoparticles

  • Mucin nanoparticles cross-linked with anti-miRNA oligonucleotides
  • Treating systemic diseases associated with increased cellular RNA levels
  • Depletion of miRNA-21 reduced tumor growth in vivo by 50%
• A Biomarker for Post-COVID Syndrome

  B83046

  A Biomarker for Post-COVID Syndrome

  • Simplified diagnosis of Post-Covid
  • Identification of PCS-specific SARS-CoV-2 S-protein epitopes
  • Demonstrated feasibility of high-throughput screening
• Improved oral delivery of lipid-based formulations

  B81169

  Improved oral delivery of lipid-based formulations

  • Solid SMEDDS-loaded metal-organic compounds
  • pH-responsive and tight drug release control
  • Customization through 3D printing
• Novel clinical biomarker for hepatic steatosis

  B82088

  Novel clinical biomarker for hepatic steatosis

  • Applicable for detecting or grading hepatic steatosis
  • Fast, simple and inexpensive
  • Minimal non-invasive
• BICEP: A Bio- Inspired Compliant Elbow Prosthesis

  B82103

  BICEP: A Bio- Inspired Compliant Elbow Prosthesis

  • Compact and bio-inspired joint design with soft properties
  • Compliant behavior in both the sagittal and transversal planes
  • Safe absorption of unintentional impacts
• Puncturing system for a safer tracheostomy

  B81019

  Puncturing system for a safer tracheostomy

  • Enables the physician to reliably identify the correct site and trajectory of the puncturing instrument
  • Especially suited for patients with a challenging anatomy (e.g obese tissue, goiter, short neck)
  • PDT significantly decreases costs, time and manpower requirements
• Grainstorm revolutionizes the ethanolic fermentation of starchy raw materials in the production of distilled spirits and simplifies starch-based fermentation

  B81132

  Grainstorm revolutionizes the ethanolic fermentation of starchy raw materials in the production of distilled spirits and simplifies starch-based fermentation

  • Mashing takes place at low temperatures with a dispersing device (up to 32°C)
  • No need for cooling the mash, fermentation at mashing temperature
  • Complete conversion of starch, very high yields
  • Greatly simplified process execution, significant savings in equipment and mashing time
• Screening for drugs to promote or inhibit Mreg-induced Treg development

  B77143

  Screening for drugs to promote or inhibit Mreg-induced Treg development

  • identify drugs substances and/or drug targets involved in Mreg-mediated iTreg generation
  • high reproducibility & technically simple
  • reduced sample processing times and costs
• Peptide agent against multi-resistant bacteria

  B81112

  Peptide agent against multi-resistant bacteria

  • antibacterial agent for multi drug resistant Gram-negative infections
  • fast action (hours), also bactericidal against non-replicating bacteria
  • especially for patients with autoantibodies against endogenous BPI
• LINAC Cavities Made by Additive Manufacturing

  Y20000

  LINAC Cavities Made by Additive Manufacturing

  • Relevant reduction of manufacturing costs
  • Freedom in cavitiy design due to additive manufacturing
  • Optimized cavity geometries reduce LINAC operating costs while increasing operating time and lifetime
  • Innovation can be used in particle accelerators for e.g. radiation therapy, cargo scanning or food
• New catalysts for the production of superior PHB

  B82063

  New catalysts for the production of superior PHB

  • Biocompatible and biodegradable plastic with superior material properties compared to bacterial PHB
  • Cost-effective production via ring opening polymerization of ß‐butyrolactone
  • Thermomechanical properties similar to petrochemical PP, material suitable for melt processing
• Advanced Radio-guided Surgery: Tc-99m-labelled Nanoparticles for the Detection of Sentinel Lymph Nodes

  B82027

  Advanced Radio-guided Surgery: Tc-99m-labelled Nanoparticles for the Detection of Sentinel Lymph Nodes

  • Radio-guided Surgery
  • Radiopharmaceutical
  • Nanotechnology
• Coating of Catheter-based Cardiac Devices using TRPC6 Inhibitors for Prevention of Restenosis

  B79124

  Coating of Catheter-based Cardiac Devices using TRPC6 Inhibitors for Prevention of Restenosis

  • Scar tissue as a central problem after stent implantation
  • Local coating of cardiac devices inhibits re-narrowing of vessel
  • Dual anti-proliferative and anti-migratory effect on cells
• The T-Cell-Therapy Success Code: Signatures of recent T-cell activation allow isolation of highly functional tumor-specific T cell receptors

  B81078

  The T-Cell-Therapy Success Code: Signatures of recent T-cell activation allow isolation of highly functional tumor-specific T cell receptors

  • Cost-effective isolation of highly functional tumor-specific TCRs
  • Method using predictive markers to identify TCRs of high functional quality
  • Isolation of TCRs from easily accessible peripheral blood
• PosH-Tag: Cost effective and highly specific biomolecule separation with bare silica surfaces and immobilization using bare magnetic iron-oxide nanoparticles

  B80037

  PosH-Tag: Cost effective and highly specific biomolecule separation with bare silica surfaces and immobilization using bare magnetic iron-oxide nanoparticles

  • Platform for protein purification and immobilization
  • Efficient and cost effective separation of target molecules
  • Without NTA modification and the use of imidazole
• New cell therapy cures metastatic cancer in mouse

  B81137

  New cell therapy cures metastatic cancer in mouse

  • New RESURRECT NK and T cell therapy cures metastatic cancer in mouse
  • RESURRECT T and NK cells overcome immunosuppression in tumors and metastases
  • RESURRECT cells are effective in tumors resistant to standard immunotherapies
• Novel approach for surgical stabilization of disrupted pubic symphysis in pelvic injuries

  B80189

  Novel approach for surgical stabilization of disrupted pubic symphysis in pelvic injuries

  • Trauma accidents often result in life threatening pelvic injuries
  • 2 component cable-clamp implant for disrupted pubic symphysis
  • Fewer complications compared to conventional approach
• Anti-PSMA antibodies for therapeutic and diagnostic purposes

  B80048

  Anti-PSMA antibodies for therapeutic and diagnostic purposes

  • Anti-PSMA antibody with sub-nanomolar affinity high specificity for native PSMA and good thermal stability
  • Pre-clinical optimization for developability
  • Among others, suitable for antibody-drug-conjugates, photodynamic therapy or imaging
• Implant and implant applicator for endoscopic and customizable anastomosis

  B80080

  Implant and implant applicator for endoscopic and customizable anastomosis

  • System for endoluminal anastomosis
  • Adjustable to the lumen size of the patient’s intestine
  • Force application mechanism at flexible endoscope tip for arbitrary shapes
• Controlled release of therapeutical agents from polymer brush coatings by employing reversible polymer condensation using ionic cross-linkers

  B79086

  Controlled release of therapeutical agents from polymer brush coatings by employing reversible polymer condensation using ionic cross-linkers

  • Surface coat with drug encapsulation for medical implants
  • Triggered drug release by contact with physiological salt concentrations
  • Quickly achieve therapeutic levels at actual site of inflammation
• Nanoparticles for the targeted treatment of neovascular ocular diseases

  B79130

  Nanoparticles for the targeted treatment of neovascular ocular diseases

  • systemic therapy instead of intravitreal antibody injections
  • a single systemic injection cured retinopathy of prematurity in mouse model
  • causal treatment of all neovascular ocular diseases
• Lab on a Chip for rapid testing applications

  B79091

  Lab on a Chip for rapid testing applications

  • Rapid detection of bio-chemical substances in fluids
  • Easy and fast – requires only small amount of testfluid
  • No sample preparation needed
• Natural Antioxidants for food or cosmetic oils and fats

  B78099 | B79090

  Natural Antioxidants for food or cosmetic oils and fats

  • Highly effective, edible natural antioxidants for oils and fats
  • Antioxidant and antibacterial effects for long shelf life
  • For edible oils and fats, cosmetics and other oil-based products
• Liposome-encapsidated bioactive hexapeptides for targeted pancreatic cancer therap

  B80078

  Liposome-encapsidated bioactive hexapeptides for targeted pancreatic cancer therap

  • Targeted tumor therapy for highly aggressive pancreatic cancers
  • Particularly suited for combinational therapy
  • Targeted therapies for human solid tumors bearing wild-type TP53
• Sustainable one-pot preparation of versatile organo-phosphorus compounds

  B79039

  Sustainable one-pot preparation of versatile organo-phosphorus compounds

  • Simple one-pot reaction using mild, non-corrosive conditions
  • Reaction yields e.g. stannyl phosphines for direct reaction with electrophiles
  • No separation/purification steps necessary
• TMEM16A inhibitors as a treatment option for cystic fibrosis

  B78025

  TMEM16A inhibitors as a treatment option for cystic fibrosis

  • TMEM16A inhibitors represent a causal treatment for cystic fibrosis
  • They reduce both excessive mucus formation and airway contraction
  • Repurposing possible: TMEM16A inhibitors include FDA-approved and well-tolerated drugs
• Learning-based beamforming for acoustic and ultrasonic applications

  B77199

  Learning-based beamforming for acoustic and ultrasonic applications

  • Ultrasound beamforming
  • Deep learning
  • High quality for real time imaging
• Virus-mimetic nanoparticles for diabetic nephropathy

  B79122

  Virus-mimetic nanoparticles for diabetic nephropathy

  • Specific drug delivery via nanoparticles
  • Virus like targeting in a two-stage process
  • Dose reduction compared to free drug
• Innovative solid-liquid reactor for high-speed mass transfer & catalysis without clogging

  B78159

  Innovative solid-liquid reactor for high-speed mass transfer & catalysis without clogging

  • Fully scalable rotating reactor for quick mass transfer reactions
  • Broad variety of chemical- and pharmaceutical applications such as extraction & biocatalysis
  • Especially effective for the use of small or deformable particles as solid reactant (no clogging)
• Reducing waste and time – Novel approach allows for rapid isotope production for medical diagnostics

  B78139

  Reducing waste and time – Novel approach allows for rapid isotope production for medical diagnostics

  • ⁹⁹ᵐTc as one of the most important medical radioisotopes
  • Novel dry-chemical separation of molybdenum and uranium
  • More environmentally friendly production with less toxic waste
• Innovative braiding technique and bifurcation stents with a seamless transition area

  B78126

  Innovative braiding technique and bifurcation stents with a seamless transition area

  • Optimized braiding technique for bifurcation stents
  • Seamless transition area with a homogenous density for maximum stability and flexibility at bifurcation sites
  • Secondary branches can be produced simultaneously
• Tau aggregation inhibiting peptides as a basis for future therapies for tauopathies

  B79054

  Tau aggregation inhibiting peptides as a basis for future therapies for tauopathies

  • Tau aggregation inhibiting peptides
  • Strongly bind to tau monomers, -oligomers and -fibrils
  • Suitable for future tauopathy therapies
• Novel heavy metal complexes as ex-vivo contrast agents for computed tomography scanning of biological samples

  B76184 / B76179

  Novel heavy metal complexes as ex-vivo contrast agents for computed tomography scanning of biological samples

  • Novel contrast agents for histological methods
  • Drastic contrast enhancement for CT scanning
  • Facilitation of highly detailed 3D information
• Point-of-care blood test for early sepsis diagnosis

  B79000

  Point-of-care blood test for early sepsis diagnosis

  • Diagnostic test for suspected sepsis (bacterial, viral incl. SARS-CoV, fungal)
  • Easy and broadly applicable test, small blood sample volumes needed
  • Allows much earlier diagnosis (~36h) than currently possible
• Method and System to Detect a Solute in a Solvent using Nuclear Magnetic Resonance

  B77091

  Method and System to Detect a Solute in a Solvent using Nuclear Magnetic Resonance

  • MRI-based detection of non-toxic agents and approved X-ray contrast agents
  • Simple interpretation of results due to less interference compared to CEST-type techniques
  • Non-invasive measurement of pH-values or temperature
• Success Prediction of an Allergen- specific Immunotherapy

  B76137

  Success Prediction of an Allergen- specific Immunotherapy

  • Innovative prediction method for the therapeutic success of an allergen-specific immunotherapy (AIT) at an early stage
  • straightforward and easy determination of the relevant parameters from nasal sample material
  • patient-friendly and economic
• Macrocyclic Inhibitory Peptide with Potent Anti-amyloid Effect in Alzheimer’s Animal Model

  B78094

  Macrocyclic Inhibitory Peptide with Potent Anti-amyloid Effect in Alzheimer’s Animal Model

  • Macrocyclic peptides with drug-like properties
  • Highly potent inhibitors of Aβ amyloid self-assembly
  • Promising in vivo data from Alzheimer’s mouse model
• Protein Purification/Immobilization through negPeps

  B76080

  Protein Purification/Immobilization through negPeps

  • NegPeps (magnetic particle binding peptides) are novel peptides with the potential to replace the common affinity tags based protein purification/immobilization
  • NegPeps bind to magnetic nanoparticles in a reversible and controlled manner
  • No specific surface functionalization necessary
• Rotating reactor for heterogeneous ­transfer of substances

  B78159

  Rotating reactor for heterogeneous ­transfer of substances

  • Reactor for mass transfer reactions
  • Biotech, food and beverage processing
  • For small or deformable particles
• NF-κB-activated dendritic cells

  B71259

  NF-κB-activated dendritic cells

  • that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
  • DCs activation is mediated by via mRNA transfection
  • Activated DCs lead to strong expansion of memory T cells and are much more stable than other DC vaccination products
• Needle assembly for relieving a pneumothorax

  B77122

  Needle assembly for relieving a pneumothorax

  • Fast and easy to use medical device for relieving a Pneumothorax
  • Enables safe patient transport
  • Prevents serious inadvertent injuries
• Flexible and breathable nonwovens with superior electrical conductivity

  B76140

  Flexible and breathable nonwovens with superior electrical conductivity

  • Bendable and breathable material with metal-like electrical conductivity
  • Low silver content required, simple wet-laid process
  • For e.g. lightweight electrodes and electric shielding
• Innovative ceramic fiber composite materials with high thermal and corrosion stabilities

  B74087, B76032

  Innovative ceramic fiber composite materials with high thermal and corrosion stabilities

  • Superior ceramic fiber prepregs for high-temperature stable materials
  • Prepregs storable without climate control, reversible drying process
  • Little to no volume shrinkage during sintering
• Method for assessing the efficacy of immunmodulatory drugs

  B74042

  Method for assessing the efficacy of immunmodulatory drugs

  • Biomarker using CD147/MCT1 destabilization as mechanism
  • For the use of IMiDs (Immunomodulatory drugs)
  • To treat hematologic malignancies like multiple myeloma (MM)
• A calcium-sensor for NMR/MRI based diagnostic imaging using hyperpolarized xenon

  B75123

  A calcium-sensor for NMR/MRI based diagnostic imaging using hyperpolarized xenon

  • in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
  • in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
• PH-biosensor based on hyper-polarized zymonic acid for non-invasive imaging and spectroscopy

  B73167

  PH-biosensor based on hyper-polarized zymonic acid for non-invasive imaging and spectroscopy

  • Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
  • Potential for diagnosis and therapy of diseases characterized by aberrant acid-base balances

46 of 95 Tech Offers