Search Results

Antioxidants and antibacterials for bio-based fuels and lubricants

Aug 12, 2019

| Reference: 

B78099 / B79090

• Highly effective, non-toxic natural antioxidants for long shelf-life

• Eco-friendly antibacterials for hydrophobic formulations

• For fuels, lubricants, and other oil or fat based technical products

Read more

Site-specific protein ubiquitylation and SUMOylation using genetic-code expansion and sortase-mediated transpeptidation

Aug 7, 2019

| Reference: 

B78098

• Combination of genetic-code expansion, bioorthogonal Staudinger reduction and sortase-mediated transpeptidation

• Preparative in vitro ubiquitylation and SUMOylation of various target proteins

• Building an orthogonal ubiquitylation pathway in mammalian cells.

Read more

Novel 18F-labeled PET tracers targeting RAS for cardiology and oncology

Aug 6, 2019

| Reference: 

B77016

• Simple, low-cost synthesis, longtracer half-life

• Specifically targetsRenin-Angiotensin-Aldosterone-System (RAS)

• For PET diagnostic

Read more

Superior BChE inhibitors for Alzheimer’s Disease

Aug 6, 2019

| Reference: 

B78084

• Highly potent BChE inhibitors

• BChE inhibitors with neuroprotectant properties

• Long and controllable duration of action

Read more

GRAND-SLAM - The Method for quantification of new and old RNA

Jul 24, 2019

| Reference: 

B78083

• Metabolic labelling using SLAM-seq, TUC-seq or TimeLapse-seq

• Enable fully quantitative analyses of RNA (incl. single cell)

• Usable in vertebrates, insects, plants and yeast, in vitro as well as in vivo

Read more

WEAR-LEVELING CIRCUITRY FOR AGING ­ EFFECTS MITIGATION

Jun 27, 2019

| Reference: 

B78090

• Effective mitigation of aging in SRAMs Sense amplifiers
• Low-cost circuitry
• Minimal indrease of the performance and read overhead

Read more

ROTATING REACTOR FOR HETEROGENEOUS ­TRANSFER OF SUBSTANCES

Jun 25, 2019

| Reference: 

B78159

• Reactor for mass transfer reactions
• Biotech, food and beverage processing
• For small or deformable particles

Read more

3D SCATTERING TENSOR BASED ON ONE OR TWO AXES OF ROTATION

Jun 7, 2019

| Reference: 

B76005

• Shorter acquisition time and fasterreconstruction procedure

• Full scattering tensor with multipleindependent structural parameters for each volume element

• Visualizing sub-pixel fiber orientations

Read more

Needle assembly for relieving a pneumothorax

May 27, 2019

| Reference: 

B77122

• Fast and easy to use medical device for relieving a Pneumothorax

• Enables safe patient transport

• Prevents serious inadvertent injuries

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FLEXIBLE AND BREATHABLE NONWOVENS WITH SUPERIOR ELECTRICAL CONDUCTIVITY

Jun 4, 2019

| Reference: 

B76140

• Bendable andbreathable material with metal-like electrical conductivity

• Low silver contentrequired, simple wet-laid process

• For e.g. lightweight electrodesand electric shielding

Read more

INNOVATIVE CERAMIC FIBER COMPOSITE MATERIALS WITH HIGH THERMAL AND CORROSION STABILITIES

Jun 4, 2019

| Reference: 

B74087 | B76032

• Superior ceramic fiberprepregs for high-temperature stable materials

• Prepregs storablewithout climate control, reversible drying process

• Little to no volumeshrinkage during sintering

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BREATHABLE, ULTRA-LIGHTWEIGHT ­ELECTROCONDUCTIVE FOAMS

Jun 4, 2019

| Reference: 

B74226

• Flexible, breathablefoams with high electro-conductivity

• Simple, scalablemetallization process (using e.g. copper or silver)

• Fast heating capacity

Read more

X-RAY PLUS OPTICAL DATA: APPARATUS AND METHOD FOR AUGMENTED VISUALIZATION

May 13, 2019

| Reference: 

B76010

• Combined x-ray and optical imaging

• Improved image quality

• Large working space for surgeons

Read more

Method for assessing the efficacy of immunmodulatory drugs

Apr 1, 2019

| Reference: 

B74042

• Biomarker using CD147/MCT1 destabilization as mechanism

• For the use of IMiDs (Immunomodulatory drugs)

• To treat hematologic malignancies like multiple myeloma (MM)

Read more

VEHICLE INDIVIDUAL CAN-PROFILE FOR SECURE COMMUNICATION BETWEEN CONTROL UNITS

Apr 8, 2019

| Reference: 

B78004

• Fast and secure data transfer
• Obfuscated communication instead of encrypted communication
• Individual CAN-Profileper vehicle

Read more

PIEZOELECTRIC ELECTROMAGNETIC INTERFERENCE FILTER

Apr 8, 2019

| Reference: 

B78011

• Effective Filtering of electromagnetic disturbances
• High tunability
• Low-cost and broad applicability

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PROGNOSTIC AND PREDICTIVE BIOMARKER FOR MELANOMA

Mar 29, 2019

| Reference: 

B78091

• Prognostic test for patients with malignant melanoma
• Estimates patient life expectancy
• Biomarker for predicts melanoma therapy response

Read more

FUEL AND ADDITIVES FOR BIOFUEL FORMULATION

Mar 14, 2019

| Reference: 

B77015, B77099, B78099

• Green fuel with improved combustion and viscosity/freezing point
• Lower particulates and exhaust gas emissions compared to petroleum diesel
• Highly effective, non-toxic natural antioxidants for long storage life

Read more

PROCESS FOR THE SYNTHESIS OF PHB BIOPLASTICS

Mar 6, 2019

| Reference: 

B77105

• Biocompatible and biodegradable plastic with superior properties
• Suitable for packaging, surface coating and polymer blends
• Competitive green substitute for petrochemical plastics

Read more

NEW CATALYST SYSTEM FOR HIGH PERFORMANCE POLYMERS

Mar 6, 2019

| Reference: 

B75246, B74151, B76002, B76107, B76177

• Superior method for the polymerization of Michael-type based monomers
• New versatile catalyst system
• Cheaper, fasterand  greener process

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SUPERHYDROPHOBIC “LOTUS EFFECT” SURFACE COATING

Mar 6, 2019

| Reference: 

B73221

• Superhydrophobic, breathable non-stick coating
• Finishing for varioussurface materials
• Green, organicsolvent-free process  

Read more

ECO-FRIENDLY CHOLINE SURFACTANTS AND DETERGENTS WITH HIGH COLD-WATER SOLUBILITY

Mar 6, 2019

| Reference: 

B69024, B77023

• Highly effective eco-friendly surfactants and detergents
• Low-temp and hard-water robustness
• Cost-effective production from various raw materials

Read more

INTUITIVE LOCOMOTION IN VIRTUAL REALITY

Mar 6, 2019

| Reference: 

B78048

• Intuitive locomotion in virtual reality
• Direction of motion determined independently of viewing direction
• Completely compatible with existing body-tracking systems

Read more

FILTER BANKS AND METHODS FOR OPERATING FILTER BANKS

Mar 6, 2019

| Reference: 

B75223

• Novel implementation of DFT- based modulated filter banks
• Less space used on the chip and longer battery lifetime
• Wide range of applications in digital signal processing

Read more

NON-INVASIVE ULTRASOUND INVESTIGATION OF COMPOSITION AND TEMPERATURE OF FLUID MIXTURES

Mar 6, 2019

| Reference: 

B70063

• Simultaneous monitoring of temperature and composition
• Non-invasive monitoring of non-isothermal processes
• Sensors well suited for IIOT applications

Read more

TOUCH-SENSITIVE CLADDING PANELS USING SURFACE ACOUSTIC WAVES

Mar 6, 2019

| Reference: 

B69128, B70301

• Touch sensitive cladding panels
• Functionalize almost any sheeting material
• Touch position detection

Read more

ACOUSTIC DETECTION OF THIN FILMS IN FLUID- FILLED HOSES AND PIPES

Mar 6, 2019

| Reference: 

B69127, B77157

• Deposition monitoring in fluid conduits
• Non-invasive online monitoring
• Sensors well suited for IIOT applications

Read more

DOUGH RELAXATION TROUGH ELECTROMAGNETIC PULSES

Feb 25, 2019

| Reference: 

B78143

• Drastic shortening of the baking time
• Easy processability of the dough
• High controllability of the preparation parameter

Read more

DEVICE AND METHOD FOR MATERIAL TESTING IN APPLICATION-RELATED CONDITIONS

Feb 25, 2019

| Reference: 

B78003, B78024

• Novel device and method enabling materials testing under realisti catmospheric conditions.
• Enabling quasistatic and cyclical experiments.
• Enabling high and realistic cooling rates.

Read more

PROCESS FOR THE ISOLATION OF NATURAL FRAGRANCES

Feb 25, 2019

| Reference: 

B75122

• Fast low-temperature extraction of natural fragrances
• Mild, non-toxic and effective
• Water based green process

Read more

ACOUSTIC DETECTION OF LIQUID DROPLETS ON SOLID SURFACES

Dec 18, 2018

| Reference: 

B69126

  • Large area monitoring with few acoustic sensors
  • Continuous monitoring of industrial infrastructure
  • Droplet position detection
Read more

FASTER LITHIUM-ION BATTERY CELL PRODUCTION PROCESS

Nov 23, 2018

| Reference: 

B77059

  • Reduced cost per Ah
  • Higher through put rates
  • Higher capacity at lower weight
  • Less production steps
Read more

ECONOMICAL MOSFETMULTI- LEVEL-CONVERTER

Nov 23, 2018

| Reference: 

B77014

  • Economical MOSFET-based Power Converter
  • High Efficiency Electromobility
  • Broad Range and Flexibility of Conversion Applications

Read more

SNIP: A NEW SEMICONDUCTOR MATERIAL

Nov 23, 2018

| Reference: 

B75074

  • Tin phosphor iodide (SnIP) is a new semiconductor material
  • Photoluminescence in the visible makes it interesting for solar cells and light emitting diodes
  • First inorganic double helix structure material
Read more

3D-PRINTER WITH HIGH SPEED AND HIGH RESOLUTION

Nov 29, 2018

| Reference: 

B75227

  • Additive Manufacturing
  • High speed and Nanoscale resolution
  • For MedTech and or production of Nano-Optics
Read more

THz AND MIR SOURCE AT ROOM TEMPERATURE IN DFG-QCLs

Nov 7, 2018

| Reference: 

B76162

  • THz sources at room temperature operation
  • Wide choice of substrate and wave-guide form
  • Compact, robust and easy to operate
Read more

EFFICIENT CONDENSATION FOR ORGANIC RANKINE CYCLES

Nov 7, 2018

| Reference: 

B76094

  • Higher electricity output and cheaper production costs/larger profit margin
  • Market: For industrial waste heat in Germany: 65 PJ/a (T>150°C)
  • The invention can be adapted in novel products by manufacturers or as a retrofit in existing plants
Read more

INFINITE LOOP DETECTION

Nov 7, 2018

| Reference: 

B76069

  • Hardware or software implemented infinite loop detection
  • Efficient way to identify suspicious branch sequences on-the-fly
  • Improves software safety and security
Read more

SPEEDING UP COMBINED CYCLE POWER PLANTS

Nov 7, 2018

| Reference: 

B74077

  • Gas and steam power plant are enabled to take part in the electricity spot market
  • Reduced cost by reduced fatigue damage by up to 90%
  • Retro fit possible
Read more

SCHWEISSVERFAHREN FÜR UNTERSCHIEDLICHE MATERIALKOMBINATIONEN

Nov 7, 2018

| Reference: 

B70287

  • Unterschiedliche Materialkombinationen können verbunden werden
  • Auch schwer schweißbare Werkstoffe können verarbeitet werden
  • Keine Erwärmung auf Schmelztemperatur notwendig
Read more

GLYKO-ENGINEERED INTERLEUKIN-4 BASED ANTAGONISTS

Nov 23, 2018

| Reference: 

B77153

  • New strategy for the generation of a novel IL4-based IL4/IL13-Inhibitor
  • Innovative application of N-glycan structures for development of receptor antagonists
  • Applicable for following areas: atopic dermatitis, allergy and allergic asthma
Read more

A CALCIUM-SENSOR FOR NMR/MRI BASED DIAGNOSTIC IMAGING USING HYPERPOLARIZED XENON

Nov 7, 2018

| Reference: 

B75123

  • in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
  • in particular for diagnosing and/or monitoring treatment of diseases
Read more

PH-BIOSENSORS BASED ON HYPERPOLARIZED ZYMONIC ACID FOR NONINVASIVE IMAGING AND SPECTROSCOPY

Oct 30, 2018

| Reference: 

B73167

  • Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
  • Potential for diagnosis and therapy of diseases characterized by aberrant acid-base balances
Read more

3D-PRINTING WITH STAMPS OR CONSTRUCTION BRICKS

Oct 17, 2018

| Reference: 

B73089

  • 3D printing
  • Material and time saving process
  • Rapid Prototyping
Read more

SELECTIVE PROTEIN KINASE INHIBITORS TARGETING EPHA2

Oct 17, 2018

| Reference: 

B76157

  • novel EphA2 kinase inhibitors that borrow the chemical scaffold of the drug Dasatinib
  • higher selectivity compared to the existing non-designated alternatives l
  • less likely to be accompanied by side effects arising from off-target inhibition
Read more

AMYLOID INHIBITORY PEPTIDES FOR ALZHEIMER`S DISEASE AND DIABETES

Oct 17, 2018

| Reference: 

B78094

  • macrocyclic peptides (MCIPs): novel class of nanomolar amyloid inhibitors of both Aβ40(42) and IAPP or of Aβ40(42) alone
  • candidates/leads for macrocyclic peptide‐based anti‐amyloid drugs
  • scaffolds for the design of small‐molecule peptidomimetics for targeting amyloidogenesis
Read more

GUIDE VANE FOR AN AXIAL KAPLAN TURBINE

Oct 17, 2018

| Reference: 

B77046

  • Reduced exit swirl downstream of the runner and efficiency improvement                                              
  • Reduction of the dimensions and costs of the turbine                                                                                  
  • Easy synchronization with the turbine generator in the start-up phase
Read more

ADAPTIVE SUCTION HOOD SYSTEM

Oct 17, 2018

| Reference: 

B74143

  • Distance reduction between collecting element and machine                                                                                
  • Increased performance                                                            
  • High versatility
Read more

IMMUNOTHERAPY FOR CHRONIC LIVER DISEASES

Sep 3, 2018

| Reference: 

B72272

  • Novel vaccination strategy against chronic liver diseases through stimulation of IMATEs with TLR9-L
  • IMATEs are an anatomic compartment within the liver tissue consisting of myeloid cells
  • iMATEs overcome regulatory cues that limit immune response during chronic liver infections
Read more

METHOD FOR THE DETERMINATION OF SATELLITE CORRECTION FOR PRECISEPOINT- POSITIONING

Sep 3, 2018

| Reference: 

B77131

  • Fast convergence of satellite corrections                      
  • Possibility of choosing the type of precessing                
  • Mutiple-frequency measurements

Read more

A CONVERTIBLE MULTI-PURPOSE BIOREACTOR

May 4, 2018

| Reference: 

B76089

  • ‍Convertible multi-purpose bioreactor provides 4in1 combination of different types of bioreactosr:
  • stirred-tank bioreactor
  • gas-lift bioreactor
  • packed-bed biofilm reactor
  • trickling filter biofilm reactor
Read more

PROCESS FOR THE PRODUCTION OF ALCOHOLS

Apr 16, 2018

| Reference: 

B77074

  • Synthesis gas (e.g. CO, CO2, H2) is converted by microorganisms in a bioreactor 
  • cascade of two serially connected stirred-tank reactors 
  • Utilization for small application as well as for industrial scale up
Read more

SUCCESS PREDICTION OF AN ALLERGEN SPECIFIC IMMUNOTHERAPY

Mar 23, 2018

| Reference: 

B76137

  • Innovative prediction method for the therapeutic success of an allergen-specific immunotherapy (AIT) at an early stage
  • straightforward and easy determination of the relevant parameters from nasal sample material
  • patient-friendly and economic
Read more

ROBUST WIFI-BASED INDOOR LOCALIZATION

Mar 19, 2018

| Reference: 

B77076

  • Navigation through a building with the aid of a smatphone app
  • Highly precise localization (below 1m)
  • Robustness to environmental changes
Read more

COMPACT UNIT FOR COST-EFFICIENT PUNCH VELOCITY CONTROL

Mar 19, 2018

| Reference: 

B76058

  • Velocity modulation with respect to the upper stage tool velocity
  • Simulataneous operation
  • Quality improvement of the workpiece
Read more

MOBILIZING BROWN FAT THERMOGENESIS

Nov 25, 2017

| Reference: 

B75239

  • Endogenously occuring natural peptide
  • Non-adrenergic activator
  • Increasing negative energy
Read more

QUICK SIMULATION OF THE LOAD ON A DISTRIBUTION GRID

Nov 27, 2017

| Reference: 

B75231

  • Electrical distribution grid simulation
  • Extremely small conputational time
  • Versatile implementation (small and big distribution grids)
Read more

DETECTION AND TRACKING OF OBJECTS IN WATER USING A NOVEL SONAR TECHNIQUE

Nov 14, 2017

| Reference: 

B75144

  • High temporal resolution
  • Measurement of the change of acustic impedence and frequency
  • Identifying and trascking of single individuals (water animals)
Read more

PACKING SOLUTION FOR FIXING POT PLANTS AND OTHER SENSITIVE PRODUCTS

Nov 13, 2017

| Reference: 

B76191

  • Safe transportation of sensitive goods
  • Cost effective
  • Less package material
Read more

IMPROVING ELECTRON BEAM MELTING

Nov 13, 2017

| Reference: 

B76154

  • Higher resolution
  • Faster build up process
  • More energy efficient
Read more

LOCAL IMMUNE CHECKPOINT INHIBITION

Nov 13, 2017

| Reference: 

B75080

  • Trispecific molecules (LiCADs, local inhibitor checkpoint antibody derivatives) enable local (tumor) immune checkpoint inhibition, which avoids systemic side effects
  • LiCADs comprise binding sites with specificity for a tumor cell, for an effector cell and for a checkpoint molecule
  • Checkpoint binding is restricted and concentrated to tumor cells avoiding undesired toxicity to healthy cells and accordingly systemic side effects
Read more

NF-κB-ACTIVATED DENDRITIC CELLS

Nov 13, 2017

| Reference: 

B71259

  • that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches


  • DCs activation is mediated by via mRNA transfection
  • Activated DCs show increased IL-12 production, have the capacity to repetitively stimulate and expand antigen-specific CTLs, lead to strong expansion of effector T cells (memory T cells) and are much more stable compared to other DC vaccination products
Read more

URINARY MARKER FOR BLADDER CANCER DETECTION

Nov 13, 2017

| Reference: 

B71211

  • The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
  • LASP-1 overcomes the limitation of currently used cystoscopy and urine cytology for diagnosis of UCB
  • LASP-1 is detected in voided urine sediment of bladder cancer patients and is combinable with a second marker to further raise specificity/sensitivity
Read more

HYPER: HYBRID OLTP&OLAP HIGH ­PERFORMANCE DATABASE SYSTEM

Nov 13, 2017

| Reference: 

B70096

• Simultaneous OLAP-transactions andOLTP-queries
• Arbitrarily current and consistent snapshotsof OLTP data
• Guarantees the ACID properties

Read more

DETECTION OF IMPURITIES IN THE SUB-PPB RANGE

Sep 17, 2018

| Reference: 

B69177

  • Detection for  impurities in sub-ppb range in liquid phase                                                                          
  • Continuous flow measurement
  • Spectroscopic approach for metallics impurities and emtallic complexes
Read more

HIGHLY ACTIVE AND SELECTIVE LIGANDS FOR INTEGRIN avß6

Oct 27, 2017

| Reference: 

B75165

  • Highly upregulated avß6 in different types of cancer
  • Peptides with remarkable affinity and high selctivity
  • No binding affinity toward other RGD-recognizing integrins
Read more

VSV/NDV HYBRID VIRUS CANCER THERAPY

Sep 3, 2018

| Reference: 

B75267

  • ‍VSV/NDV hybrid enables efficient tumor cell killing.
  • VSV/NDV hybrid virus effectively overcomes the safety concerns of each parental virus and
  • combines the advantages of both vesicular stomatitis virus (VSV) and Newcastle disease virus (NDV) vectors
Read more

HYDROGELS: INJECTABLE DEPOT-SYSTEMS

Sep 18, 2018

| Reference: 

B76151

  • that gelatinize by a dual mechanism based on Diels-Alder reaction and physical crosslinking
  • Stability and stiffness can be adjusted to therapeutic need
  • Hydrogels are stable, in situ forming, non-toxic and particularly suitable for controlled drug release
Read more

PROTEIN PURIFICATION/IMMOBILIZATION THROUGH NEG-PEPS

Sep 16, 2017

| Reference: 

B76080

  • NegPeps (magnetic particle binding peptides) are novel peptides with the potential to replace the common affinity tags based protein purification/immobilization 
  • NegPeps bind to magnetic nanoparticles in a reversible and controlled manner
  • No specific surface functionalization necessary 
Read more

CONCEPT FOR HERMETIC, LOW HEAT, MINIMUM INDUCTION PACKAGING FOR SEMICONDUCTOR CHIPS

Oct 17, 2018

| Reference: 

B76018

  • Efficient protection from the atmosphere
  • Thermal resistance reduction
  • Induction and parasitics effects reduction.
Read more

RAPID FOCUS DETERMINATION DURING LASER BEAM WELDING

Sep 16, 2017

| Reference: 

B75226

  • ‍Rapid focus determination 
  • Upgradeable Easy calibration of scanner optics
Read more

MONOLITHICALLY INTEGRATED NANOWIRE LASERS ON SILICON

Oct 17, 2018

| Reference: 

B75073

  • Reduction of the production costs for laser diodes                                                                                                
  • Chip-scal optical communication
  • Increased computational speed and reduced energy consuption for digital divices
Read more

CANNULA FOR OCULAR MICRO-INJECTION

Sep 16, 2017

| Reference: 

B75028

  • ‍Intra- and sub-retinal targeted administration of drugs 
  • Easy and highly precise targeting 
  • Treatment of Age-related Macular Degeneration (AMD)
Read more

PROCESSING A FOAM WORK PIECE

Sep 16, 2017

| Reference: 

B74222

  • ‍New product properties 
  • Better processing Flexible processing
Read more

WET-LAID MEETS ELECTROSPINNING

Sep 16, 2017

| Reference: 

B74211

  • Milder to skin compared to sodium dodecyl sulfate (SDS), in combination with a reduced sensitivity to water hardness
  • Low production costs compared to ethoxylated anionic surfactants
  • Enhanced washing ability and solubilizing power due to high water solubility
Read more

NEW DRUG TARGET IN ALZHEIMER‘S DISEASE

Sep 16, 2017

| Reference: 

B74174

  • Aη-α as a new drug target and / or diagnostic marker for Alzheimer disease
  • Presence of Aη-α fragments in AD brains should be taken into account for development/applicati- on of drugs targeting Aβ or inhibiting β-secretase, since these lead to accumulation of Aη-α
  • Antibodies to detect η-secretase pathway peptides are available
Read more

ONE-POT PROCEDURE FOR NCC ISOLATION

Sep 3, 2018

| Reference: 

B74068

  • ‍Conventional Production of NCC is complex, expensive and takes several days
  • Novel simplified method for NCC isolation: neutralization-based isolation
  • Significantly enhanced yield, accelerated process and reduced water usage
Read more

A NEW TARGET IN CANCER THERAPY

Sep 16, 2017

| Reference: 

B74064

  • Cancer cells use an extracellular citrate supply as an important energy source and substrate for the synthesis of critical cellular building blocks (e.g. fatty acids). 
  • A highly specialized plasma membrane protein (pmCiC, plasma membrane citrate carrier) was found to be responsible for citrate uptake in cancer cells
  • pmCiC is a novel and specific marker and therapeutic target for cancer cells
Read more

SMALL MOLECULE HDAC6 INHIBITORS

Sep 16, 2017

| Reference: 

B73271

  • ‍HDAC6 is a promising target for the treatment of chronic immune and inflammatory disorders such as rheumatoid arthritis (RA)
  • Marbostat are new small molecule inhibitors of HDAC6 with superior characteristics: in comparison to the established HDAC6 inhibitor Tubastatin A, the new inhibitors are more potent and specific, and most importantly they highly and selectively inhibit the enzyme activity of HDAC6 without destroying the protein.
  • Provision of a viable alternative to first line NSAIDs (non-steroidal anti-inflammatory drugs) in the treatment of RA
Read more

IMPROVING STABILITY AND SECRETION OF ANTIBODIES

Sep 16, 2017

| Reference: 

B73076

  • Improvement of the biophysical properties of antibodies and enhancement of antibody secretion by imitating the stabilizing structural elements of shark antibodies
  • CL domain is modified by a conservative exchange of amino acids at two positions
  • Compared to the wild type CL, the melting point of the modified CL domain is almost 10°C higher and its stability against urea-induced denaturation is also markedly increased 
Read more

NEW SEROTONIN RECEPTOR AGONISTS

Sep 16, 2017

| Reference: 

B72118

  • New serotonin receptor 5HT1P agonists (5-Benzyloxyindalpine, 5 BOIP) for the treatment or prevention of GI diseases such as constipation and functional dyspepsia and, in particular, for relieving GI symptoms
  • In the proximal stomach, 5BOIP evokes muscle relaxation, thereby improving the gastric accommodation reflex
  • 5 BOIP is highly specific, extremely stable against hydrolysis and oxidation and is much more convenient in production than other known agonists
Read more

SMALL MOLECULE INHIBITORS OF CD40-TRAF6 INTERACTIONS

Sep 16, 2017

| Reference: 

B72031

  • New selective inhibitors for treatment of chronic inflammatory diseases, such as atherosclerosis, obesity and multiple sclerosis
  • Inhibitors selectively block CD40-TRAF6 interactions
  • The selective blockage of the CD40-TRAF6 interactions strongly reduces inflammation, whereas unwanted immune-suppressive side effects are reduced
Read more