• Biomarker using CD147/MCT1 destabilization as mechanism

• For the use of IMiDs (Immunomodulatory drugs)

• To treat hematologic malignancies like multiple myeloma (MM)

‍

• Fast and secure data transfer
• Obfuscated communication instead of encrypted communication
• Individual CAN-Profileper vehicle

• Effective Filtering of electromagnetic disturbances
• High tunability
• Low-cost and broad applicability

‍

• Prognostic test for patients with malignant melanoma
• Estimates patient life expectancy
• Biomarker for predicts melanoma therapy response

‍

• Green fuel with improved combustion and viscosity/freezing point
• Lower particulates and exhaust gas emissions compared to petroleum diesel
• Highly effective, non-toxic natural antioxidants for long storage life

• Efficient separation of small molecules
• High through put mass spectrometry analysis

• Biocompatible and biodegradable plastic with superior properties
• Suitable for packaging, surface coating and polymer blends
• Competitive green substitute for petrochemical plastics

• Superior method for the polymerization of Michael-type based monomers
• New versatile catalyst system
• Cheaper, fasterand  greener process

• Superhydrophobic, breathable non-stick coating
• Finishing for varioussurface materials
• Green, organicsolvent-free process  

• Highly effective eco-friendly surfactants and detergents
• Low-temp and hard-water robustness
• Cost-effective production from various raw materials

• Intuitive locomotion in virtual reality
• Direction of motion determined independently of viewing direction
• Completely compatible with existing body-tracking systems

‍

• Novel implementation of DFT- based modulated filter banks
• Less space used on the chip and longer battery lifetime
• Wide range of applications in digital signal processing

• Simultaneous monitoring of temperature and composition
• Non-invasive monitoring of non-isothermal processes
• Sensors well suited for IIOT applications

• Touch sensitive cladding panels
• Functionalize almost any sheeting material
• Touch position detection

• Deposition monitoring in fluid conduits
• Non-invasive online monitoring
• Sensors well suited for IIOT applications

• Drastic shortening of the baking time
• Easy processability of the dough
• High controllability of the preparation parameter

• Novel device and method enabling materials testing under realisti catmospheric conditions.
• Enabling quasistatic and cyclical experiments.
• Enabling high and realistic cooling rates.

‍

• Fast low-temperature extraction of natural fragrances
• Mild, non-toxic and effective
• Water based green process

• Large area monitoring with few acoustic sensors
• Continuous monitoring of industrial infrastructure
• Droplet position detection

• Reduced cost per Ah
• Higher through put rates
• Higher capacity at lower weight
• Less production steps

• Economical MOSFET-based Power Converter
• High Efficiency Electromobility
• Broad Range and Flexibility of Conversion Applications

‍

• Tin phosphor iodide (SnIP) is a new semiconductor material
• Photoluminescence in the visible makes it interesting for solar cells and light emitting diodes
• First inorganic double helix structure material

• Additive Manufacturing
• High speed and Nanoscale resolution
• For MedTech and or production of Nano-Optics

• THz sources at room temperature operation
• Wide choice of substrate and wave-guide form
• Compact, robust and easy to operate

• Higher electricity output and cheaper production costs/larger profit margin
• Market: For industrial waste heat in Germany: 65 PJ/a (T>150°C)
• The invention can be adapted in novel products by manufacturers or as a retrofit in existing plants

• Hardware or software implemented infinity loop detection,
• Efficient way to identify suspicious branch sequences on-the-fly
• Improves software savety and security

• Gas and steam power plant are enabled to take part in the electricity spot market
• Reduced cost by reduced fatigue damage by up to 90%
• Retro fit possible

• Unterschiedliche Materialkombinationen können verbunden werden
• Auch schwer schweißbare Werkstoffe können verarbeitet werden
• Keine Erwärmung auf Schmelztemperatur notwendig

• Effizient
• Energieeinsparung
• Schnelle Amortisierung

• New strategy for the generation of a novel IL4-based IL4/IL13-Inhibitor
• Innovative application of N-glycan structures for development of receptor antagonists
• Applicable for following areas: atopic dermatitis, allergy and allergic asthma

• in vitro, in vivo and ex vivo detection of calcium changes via NMR and MRI & Hyper-CEST
• in particular for diagnosing and/or monitoring treatment of diseases

• Reliable and non-invasive extracellular imaging sensor to localize and quantify pH
• Potential for diagnosis and therapy of diseases characterized by aberrant acid-base balances

• 3D printing
• Material and time saving process
• Rapid Prototyping

• 3D scanning
• 3D cameras
• Kinect cameras

• novel EphA2 kinase inhibitors that borrow the chemical scaffold of the drug Dasatinib
• higher selectivity compared to the existing non-designated alternatives l
• less likely to be accompanied by side effects arising from off-target inhibition

• macrocyclic peptides (MCIPs): novel class of nanomolar amyloid inhibitors of both Aβ40(42) and IAPP or of Aβ40(42) alone
• candidates/leads for macrocyclic peptide‐based anti‐amyloid drugs
• scaffolds for the design of small‐molecule peptidomimetics for targeting amyloidogenesis

• Reduced exit swirl downstream of the runner and efficiency improvement                                              
• Reduction of the dimensions and costs of the turbine                                                                                  
• Easy synchronization with the turbine generator in the start-up phase

• Distance reduction between collecting element and machine                                                                                
• Increased performance                                                            
• High versatility

• Novel vaccination strategy against chronic liver diseases through stimulation of IMATEs with TLR9-L
• IMATEs are an anatomic compartment within the liver tissue consisting of myeloid cells
• iMATEs overcome regulatory cues that limit immune response during chronic liver infections

• Fast convergence of satellite corrections                      
• Possibility of choosing the type of precessing                
• Mutiple-frequency measurements

‍

• ‍Capacitative Sensors
• Wireless sensor networks
• Touch Screens

• ‍Convertible multi-purpose bioreactor provides 4in1 combination of different types of bioreactosr:
• stirred-tank bioreactor
• gas-lift bioreactor
• packed-bed biofilm reactor
• trickling filter biofilm reactor

• Synthesis gas (e.g. CO, CO2, H2) is converted by microorganisms in a bioreactor 
• cascade of two serially connected stirred-tank reactors 
• Utilization for small application as well as for industrial scale up

• Multi Channel Systems
• Active Loudspeakers
• High-end-amplifier

• non-invasive differentiation between bilateral hyperplasia and unilateral adenoma by PET-imaging
  
• radiolabeled aldosterone synthase (CYP11B2) inhibitors with high selectively, easy synthesis and high chemical and metabolic stability
  
• alternative for the so far performed invasive diagnostic adrenal vein sampling in combination with cross-sectional imaging

• Innovative prediction method for the therapeutic success of an allergen-specific immunotherapy (AIT) at an early stage
  
• straightforward and easy determination of the relevant parameters from nasal sample material
  
• patient-friendly and economic

• Navigation through a building with the aid of a smatphone app
  
• Highly precise localization (below 1m)
  
• Robustness to environmental changes

• Velocity modulation with respect to the upper stage tool velocity
  
• Simulataneous operation
  
• Quality improvement of the workpiece

• Mesh generation
• Full automation
• High quality and time-saving

• Endogenously occuring natural peptide
• Non-adrenergic activator
• Increasing negative energy

• Electrical distribution grid simulation
  
• Extremely small conputational time
  
• Versatile implementation (small and big distribution grids)

• High temporal resolution
  
• Measurement of the change of acustic impedence and frequency
  
• Identifying and trascking of single individuals (water animals)

• Safe transportation of sensitive goods
• Cost effective
• Less package material

• Higher resolution
• Faster build up process
• More energy efficient

• Trispecific molecules (LiCADs, local inhibitor checkpoint antibody derivatives) enable local (tumor) immune checkpoint inhibition, which avoids systemic side effects
• LiCADs comprise binding sites with specificity for a tumor cell, for an effector cell and for a checkpoint molecule
• Checkpoint binding is restricted and concentrated to tumor cells avoiding undesired toxicity to healthy cells and accordingly systemic side effects

• Mortar hybrid material with superior characteristics: strong hydrophobic properties, no need for post-treatment, not harmful to the environment
• Supplementation of a bacterial biofilm leads to an increased roughness on the microscale and the nanoscale, and on both the outer and inner surface, imitating the lotus effect
• Lyophilized powder of the bacterial biofilm available as dry admixture

• Interactive Robot Skin
• Intuitive Interaction with Robots
• Save Human/Robot Collaboration

• Novel DC-vaccination strategy for cancer immunotherapy that has very little adverse effects and overcomes the limitations of DC based immunotherapy approaches
• DCs activation is mediated by triggering their NF-κB-pathway via mRNA transfection
• Activated DCs show increased IL-12 production, have the capacity to repetitively stimulate and expand antigen-specific CTLs, lead to strong expansion of effector T cells (memory T cells) and are much more stable compared to other DC vaccination products

• The focal adhesion protein LASP-1 is a novel and simply detectable marker for urothelial carcinoma of the bladder (UCB)
• LASP-1 overcomes the limitation of currently used cystoscopy and urine cytology for diagnosis of UCB
• LASP-1 is detected in voided urine sediment of bladder cancer patients and is combinable with a second marker to further raise specificity/sensitivity

• Cost Efficient Diagnostic
• Molecular Fingerprinting
• Blood Samples

• High power switch
• Graphene contacts
• Normally Off SiC transistor

• Economical processing
• Fast friction coating
• Flexible materials

• Very fast
• Unified hybrid OLAP and OLTP Data Base

• Environment Friendly
• Cost efficient
• Flexible and Reusable

• Detection for  impurities in sub-ppb range in liquid phase                                                                          
• Continuous flow measurement
• Spectroscopic approach for metallics impurities and emtallic complexes

• Gentle method for isolation of odoriferous agents
• Almost complete extraction 
• Extraction within a short time and moderate temperatures

• Highly upregulated avß6 in different types of cancer
• Peptides with remarkable affinity and high selctivity
• No binding affinity toward other RGD-recognizing integrins

• ‍VSV/NDV hybrid enables efficient tumor cell killing.
• VSV/NDV hybrid virus effectively overcomes the safety concerns of each parental virus and
• combines the advantages of both vesicular stomatitis virus (VSV) and Newcastle disease virus (NDV) vectors

• that gelatinize by a dual mechanism based on Diels-Alder reaction and physical crosslinking
  
• Stability and stiffness can be adjusted to therapeutic need
• Hydrogels are stable, in situ forming, non-toxic and particularly suitable for controlled drug release

• NegPeps (magnetic particle binding peptides) are novel peptides with the potential to replace the common affinity tags based protein purification/immobilization 
• NegPeps bind to magnetic nanoparticles in a reversible and controlled manner
• No specific surface functionalization necessary 

• Efficient protection from the atmosphere
• Thermal resistance reduction
• Induction and parasitics effects reduction.

• Novel chip technology that can be used as a data storage system, as a computer chip or a wearable
• Principle: modification of bacterial nanocellulose (BNC) with light-gated DNA-Polymerases and other components 
• Enables information read in and read out by using DNA, Polymerases and Exonucleases

• Synthesis of known polymers to be simpler and more cost-effective 
• Conversion of monomers which until now have not yet been polymerized by conventional methods 
• Highly active catalyst

• ‍Rapid focus determination 
• Upgradeable Easy calibration of scanner optics

• Reduction of the production costs for laser diodes                                                                                                
• Chip-scal optical communication
• Increased computational speed and reduced energy consuption for digital divices

• ‍Intra- and sub-retinal targeted administration of drugs 
• Easy and highly precise targeting 
• Treatment of Age-related Macular Degeneration (AMD)

• ‍New product properties 
• Better processing Flexible processing

• Milder to skin compared to sodium dodecyl sulfate (SDS), in combination with a reduced sensitivity to water hardness
• Low production costs compared to ethoxylated anionic surfactants
• Enhanced washing ability and solubilizing power due to high water solubility

• Aη-α as a new drug target and / or diagnostic marker for Alzheimer disease
• Presence of Aη-α fragments in AD brains should be taken into account for development/applicati- on of drugs targeting Aβ or inhibiting β-secretase, since these lead to accumulation of Aη-α
• Antibodies to detect η-secretase pathway peptides are available

• ‍Conventional Production of NCC is complex, expensive and takes several days
• Novel simplified method for NCC isolation: neutralization-based isolation
• Significantly enhanced yield, accelerated process and reduced water usage

• Cancer cells use an extracellular citrate supply as an important energy source and substrate for the synthesis of critical cellular building blocks (e.g. fatty acids). 
• A highly specialized plasma membrane protein (pmCiC, plasma membrane citrate carrier) was found to be responsible for citrate uptake in cancer cells
• pmCiC is a novel and specific marker and therapeutic target for cancer cells

• ‍Hydrodabcyl: A hydrophilic alternative to the commonly used dark quencher Dabcyl
• Non-immunogenic and non-toxic
• Perfectly suitable for a large variety of biological and biochemical systems

• ‍HDAC6 is a promising target for the treatment of chronic immune and inflammatory disorders such as rheumatoid arthritis (RA)
• Marbostat are new small molecule inhibitors of HDAC6 with superior characteristics: in comparison to the established HDAC6 inhibitor Tubastatin A, the new inhibitors are more potent and specific, and most importantly they highly and selectively inhibit the enzyme activity of HDAC6 without destroying the protein.
• Provision of a viable alternative to first line NSAIDs (non-steroidal anti-inflammatory drugs) in the treatment of RA

• ‍Improvement of the biophysical properties of antibodies and enhancement of antibody secretion by imitating the stabilizing structural elements of shark antibodies
• CL domain is modified by a conservative exchange of amino acids at two positions
• Compared to the wild type CL, the melting point of the modified CL domain is almost 10°C higher and its stability against urea-induced denaturation is also markedly increased 

• ‍Precise specifications of turbines and engines 
• Accurate calculation of efficiencies 
• Guaranteed performance

• New serotonin receptor 5HT1P agonists (5-Benzyloxyindalpine, 5 BOIP) for the treatment or prevention of GI diseases such as constipation and functional dyspepsia and, in particular, for relieving GI symptoms
• In the proximal stomach, 5BOIP evokes muscle relaxation, thereby improving the gastric accommodation reflex
• 5 BOIP is highly specific, extremely stable against hydrolysis and oxidation and is much more convenient in production than other known agonists

• New selective inhibitors for treatment of chronic inflammatory diseases, such as atherosclerosis, obesity and multiple sclerosis. 
• Inhibitors selectively block CD40-TRAF6 interactions
• The selective blockage of the CD40-TRAF6 interactions strongly reduces inflammation, whereas unwanted immune-suppressive side effects are reduced

• Milder to skin compared to sodium dodecyl sulfate (SDS), in combination with a reduced sensitivity to water hardness
• Low production costs compared to ethoxylated anionic surfactants
• Enhanced washing ability and solubilizing power due to high water solubility